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Research article
Correlation of the Electrophysiological and Optical Coherence Tomography Changes in patients with Thyroid-Associated Ophthalmopathy
Amany Abd El-Fattah El-Shazly
Ain Shams University Faculty of Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4194-111X
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose: to study the structural and functional changes of the optic nerve & macula in patients with thyroid-associated ophthalmopathy (TAO) patients.
Methods: Cross-sectional clinical study including 40 cases with TAO and 40 age and sex-matched healthy participants as a control. Complete ophthalmological assessment, evaluation of the proptosis, spectral domain OCT, and electrophysiological investigations (pattern electroretinogram [PERG], multifocal ERG (mfERG) & visual evoked potentials (PVEP) were performed to all participants.
Results: Retinal nerve fibre (RNFL), central foveal (CFT) thickness and mean inner macular ring thickness are thinner in cases with proptosis. MfERG showed lower Retinal Response Density1 (RRD1), Ring 1 P1 amplitude and lower five-rings N1 amplitude. Central foveal thickness showed significant positive correlation with VA, BCVA, P50 amplitude and R1 N1 amplitude (r = 0.64, 0.65, 0.40 and 0.51 with p < 0 .001, < 0 .001, < 0 .001 and < 0 .001 respectively), and negative correlation with duration of the disease, degree of proptosis, clinical activity score and R1 N1 latency (r = -0.59, -0.78, -0.41 & -0.90 with p <0.001, <0.001, <0.001 & <0.001 respectively). RNFL thickness showed negative correlation with duration of the disease, degree of proptosis and clinical activity score (-0.77, -0.71 & -0.85 with p < 0 .001, < 0 .001 & < 0 .001 respectively). Multiple regression analyses showed that the degree of proptosis and P50 amplitude were the most important determinants for CFT (p = 0.03 & 0.02); whereas the duration of the disease, and activity score were the most important determinants for average RNFL thickness (p = 0.004, and < 0.001 respectively).
Conclusion: In the absence of fundus changes, macular thinning together with functional changes detected by PERG and mfERG could be used as good predictors of subclinical retinopathy in the cases of TAO.
Keywords
Central foveal (CFT) thickness, Retinal nerve fiber layer (RNFL) thickness, Pattern electroretinogram (PERG), Pattern visual evoked potential (PVEP), Retinal Response Density (RRD), Thyroid-Associated Ophthalmopathy (TAO)
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This is a preprint. It has not completed peer review.
Research article
Correlation of the Electrophysiological and Optical Coherence Tomography Changes in patients with Thyroid-Associated Ophthalmopathy
Amany Abd El-Fattah El-Shazly
Ain Shams University Faculty of Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4194-111X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 17 Jan, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Ophthalmology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose: to study the structural and functional changes of the optic nerve & macula in patients with thyroid-associated ophthalmopathy (TAO) patients.
Methods: Cross-sectional clinical study including 40 cases with TAO and 40 age and sex-matched healthy participants as a control. Complete ophthalmological assessment, evaluation of the proptosis, spectral domain OCT, and electrophysiological investigations (pattern electroretinogram [PERG], multifocal ERG (mfERG) & visual evoked potentials (PVEP) were performed to all participants.
Results: Retinal nerve fibre (RNFL), central foveal (CFT) thickness and mean inner macular ring thickness are thinner in cases with proptosis. MfERG showed lower Retinal Response Density1 (RRD1), Ring 1 P1 amplitude and lower five-rings N1 amplitude. Central foveal thickness showed significant positive correlation with VA, BCVA, P50 amplitude and R1 N1 amplitude (r = 0.64, 0.65, 0.40 and 0.51 with p < 0 .001, < 0 .001, < 0 .001 and < 0 .001 respectively), and negative correlation with duration of the disease, degree of proptosis, clinical activity score and R1 N1 latency (r = -0.59, -0.78, -0.41 & -0.90 with p <0.001, <0.001, <0.001 & <0.001 respectively). RNFL thickness showed negative correlation with duration of the disease, degree of proptosis and clinical activity score (-0.77, -0.71 & -0.85 with p < 0 .001, < 0 .001 & < 0 .001 respectively). Multiple regression analyses showed that the degree of proptosis and P50 amplitude were the most important determinants for CFT (p = 0.03 & 0.02); whereas the duration of the disease, and activity score were the most important determinants for average RNFL thickness (p = 0.004, and < 0.001 respectively).
Conclusion: In the absence of fundus changes, macular thinning together with functional changes detected by PERG and mfERG could be used as good predictors of subclinical retinopathy in the cases of TAO.
Figure 1
Figure 2
Figure 3
Figure 4