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Research article
Jin Hu
Huashan Hospital Fudan University
Corresponding Author
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Background: The prognostic value of Neutrophil-to-Lymphocyte Ratio (NLR) for the outcome of acute cervical traumatic spinal cord injury (tSCI) patients has rarely been studied by now throughout the world.
Methods: We performed a single-center retrospective cohort study to evaluate the prognostic value of NLR from peripheral whole blood count in patients with acute cervical tSCI. Patients within 6 hours of acute cervical tSCI treated between Dec 2008 and May 2018 in Huashan Hospital of Fudan University were enrolled. Outcomes of patients with tSCI were assessed using American spinal injury association Impairment Scale (AIS). 6-month outcomes were dichotomized into poor outcome group (AIS A to C) and good outcome group (AIS D and E). Uni- and multivariate analyses were performed to assess the independent predictors of 6-month outcome. Two prediction models based on admission characteristics were built to evaluate the prognostic value of NLR. The discriminative ability of predictive models was evaluated using the area under the curve (AUC).
Results: A total of 377 patients were identified from our single center in China PR. Multivariate analysis showed that age, AIS grade at admission, NLR (p<0.001) and coagulopathy (p = 0.003) were independent predictors of the 6-months outcome for acute cervical tSCI patients. The model combing NLR and standard variables (AUC=0.944; 95% CI, 0.923-0.964) showed a more favorable prognostic value than that without NLR (AUC=0.841; 95% CI, 0.798-0.885) in terms of 6-month outcome.
Conclusions: NLR is firstly identified as an independent predictor of the 6-month outcome in acute cervical tSCI patients worldwide. The prognostic value of NLR is favorable, and a high NLR is associated with poor outcome in patients with acute cervical tSCI.
Keywords
acute traumatic cervical spinal cord injury, neutrophil-to-lymphocyte ratio, prediction model, prognostic value, 6-months outcome
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View the published article at BMC Musculoskeletal Disorders.
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Posted 07 Aug, 2020
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Review #5 received
Received 26 May, 2020
Editorial decision: Accept
On 26 May, 2020
Reviewer #5 agreed
On 23 May, 2020
Review #4 received
Received 20 May, 2020
Reviewer #4 agreed
On 29 Apr, 2020
Review #3 received
Received 19 Mar, 2020
Reviewer #3 agreed
On 12 Mar, 2020
Reviewer #2 agreed
On 09 Mar, 2020
Review #2 received
Received 09 Mar, 2020
Reviewer #1 agreed
On 04 Mar, 2020
Review #1 received
Received 04 Mar, 2020
Reviewers invited
Invitations sent on 14 Feb, 2020
Editor assigned
On 27 Jan, 2020
Submission checks complete
On 26 Jan, 2020
Editor invited
On 26 Jan, 2020
No comments provided
Submission checks complete
On 15 Jan, 2020
Editor invited
On 15 Jan, 2020
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Subject Areas
Orthopedics
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See the published version of this preprint at BMC Musculoskeletal Disorders.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Jin Hu
Huashan Hospital Fudan University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Musculoskeletal Disorders.
Version 2
Posted 07 Aug, 2020
No community comments so far
Review #5 received
Received 26 May, 2020
Editorial decision: Accept
On 26 May, 2020
Reviewer #5 agreed
On 23 May, 2020
Review #4 received
Received 20 May, 2020
Reviewer #4 agreed
On 29 Apr, 2020
Review #3 received
Received 19 Mar, 2020
Reviewer #3 agreed
On 12 Mar, 2020
Reviewer #2 agreed
On 09 Mar, 2020
Review #2 received
Received 09 Mar, 2020
Reviewer #1 agreed
On 04 Mar, 2020
Review #1 received
Received 04 Mar, 2020
Reviewers invited
Invitations sent on 14 Feb, 2020
Editor assigned
On 27 Jan, 2020
Submission checks complete
On 26 Jan, 2020
Editor invited
On 26 Jan, 2020
No comments provided
Submission checks complete
On 15 Jan, 2020
Editor invited
On 15 Jan, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Orthopedics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Musculoskeletal Disorders.
Background: The prognostic value of Neutrophil-to-Lymphocyte Ratio (NLR) for the outcome of acute cervical traumatic spinal cord injury (tSCI) patients has rarely been studied by now throughout the world.
Methods: We performed a single-center retrospective cohort study to evaluate the prognostic value of NLR from peripheral whole blood count in patients with acute cervical tSCI. Patients within 6 hours of acute cervical tSCI treated between Dec 2008 and May 2018 in Huashan Hospital of Fudan University were enrolled. Outcomes of patients with tSCI were assessed using American spinal injury association Impairment Scale (AIS). 6-month outcomes were dichotomized into poor outcome group (AIS A to C) and good outcome group (AIS D and E). Uni- and multivariate analyses were performed to assess the independent predictors of 6-month outcome. Two prediction models based on admission characteristics were built to evaluate the prognostic value of NLR. The discriminative ability of predictive models was evaluated using the area under the curve (AUC).
Results: A total of 377 patients were identified from our single center in China PR. Multivariate analysis showed that age, AIS grade at admission, NLR (p<0.001) and coagulopathy (p = 0.003) were independent predictors of the 6-months outcome for acute cervical tSCI patients. The model combing NLR and standard variables (AUC=0.944; 95% CI, 0.923-0.964) showed a more favorable prognostic value than that without NLR (AUC=0.841; 95% CI, 0.798-0.885) in terms of 6-month outcome.
Conclusions: NLR is firstly identified as an independent predictor of the 6-month outcome in acute cervical tSCI patients worldwide. The prognostic value of NLR is favorable, and a high NLR is associated with poor outcome in patients with acute cervical tSCI.
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
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