Morin inhibits Listeria monocytogenes virulence in vivo and in vitro by targeting listeriolysin O and inflammation
Background: Listeria monocytogenes ( L. monocytogenes ) is a global opportunistic intracellular pathogen that can cause many diseases, including meningitis and abortion in humans and animals; thus, L. monocytogenes poses a great threat to public safety and the development of the aquaculture industry. The pore-forming toxin listeriolysin O (LLO) is one of the most important virulence factors of L. monocytogenes ; LLO can promote cytosolic bacterial proliferation and aid in evading the attacks of the host immune system. In addition, L. monocytogenes infection can trigger a series of severe inflammatory reactions.
Results: Here, on the basis of our previous studies, we further confirmed that morin lacking anti-Listeria activity could inhibit LLO oligomerization and found that morin could effectively alleviate the inflammation induced by Listeria in vivo and in vitro and has an obvious protective effect on infected cells and mice.
Conclusions: Thus, we further prove that morin is a valuable drug precursor to be developed for the treatment of Listeria infection.
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Posted 17 Apr, 2020
On 24 Apr, 2020
Received 23 Apr, 2020
Received 21 Apr, 2020
On 17 Apr, 2020
Received 16 Apr, 2020
On 15 Apr, 2020
On 14 Apr, 2020
On 14 Apr, 2020
Invitations sent on 14 Apr, 2020
On 13 Apr, 2020
On 13 Apr, 2020
On 12 Mar, 2020
Received 10 Mar, 2020
Received 21 Feb, 2020
Received 21 Feb, 2020
Received 14 Feb, 2020
On 13 Feb, 2020
On 11 Feb, 2020
On 11 Feb, 2020
On 11 Feb, 2020
Received 11 Feb, 2020
On 30 Jan, 2020
Invitations sent on 29 Jan, 2020
On 23 Jan, 2020
On 15 Jan, 2020
On 14 Jan, 2020
On 06 Jan, 2020
Morin inhibits Listeria monocytogenes virulence in vivo and in vitro by targeting listeriolysin O and inflammation
Posted 17 Apr, 2020
On 24 Apr, 2020
Received 23 Apr, 2020
Received 21 Apr, 2020
On 17 Apr, 2020
Received 16 Apr, 2020
On 15 Apr, 2020
On 14 Apr, 2020
On 14 Apr, 2020
Invitations sent on 14 Apr, 2020
On 13 Apr, 2020
On 13 Apr, 2020
On 12 Mar, 2020
Received 10 Mar, 2020
Received 21 Feb, 2020
Received 21 Feb, 2020
Received 14 Feb, 2020
On 13 Feb, 2020
On 11 Feb, 2020
On 11 Feb, 2020
On 11 Feb, 2020
Received 11 Feb, 2020
On 30 Jan, 2020
Invitations sent on 29 Jan, 2020
On 23 Jan, 2020
On 15 Jan, 2020
On 14 Jan, 2020
On 06 Jan, 2020
Background: Listeria monocytogenes ( L. monocytogenes ) is a global opportunistic intracellular pathogen that can cause many diseases, including meningitis and abortion in humans and animals; thus, L. monocytogenes poses a great threat to public safety and the development of the aquaculture industry. The pore-forming toxin listeriolysin O (LLO) is one of the most important virulence factors of L. monocytogenes ; LLO can promote cytosolic bacterial proliferation and aid in evading the attacks of the host immune system. In addition, L. monocytogenes infection can trigger a series of severe inflammatory reactions.
Results: Here, on the basis of our previous studies, we further confirmed that morin lacking anti-Listeria activity could inhibit LLO oligomerization and found that morin could effectively alleviate the inflammation induced by Listeria in vivo and in vitro and has an obvious protective effect on infected cells and mice.
Conclusions: Thus, we further prove that morin is a valuable drug precursor to be developed for the treatment of Listeria infection.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5