1 American Cancer Society. Cancer Facts & Figures 2020. Atlanta: American Cancer Society; 2020.
2 Hu, Z. et al. Quantitative evidence for early metastatic seeding in colorectal cancer. Nature genetics 51, 1113-1122, doi:10.1038/s41588-019-0423-x (2019).
3 Kodaira S, Y. T., Nakamura K, Watanabe E, Maruyama M, Ushio K, et al. . Multi-institutional survey of sm colorectal cancer with metastases (in Japanese with English abstract). . Stomach and Intestine 29, 1137-1142 (1994).
4 Okano, K., Shimoda, T. & Matsumura, Y. Clinicopathologic and immunohistochemical study of early colorectal cancer with liver metastases. Journal of gastroenterology 34, 334-340, doi:10.1007/s005350050270 (1999).
5 Sugimoto, K. et al. T1 colorectal cancer with synchronous liver metastasis. Case reports in gastroenterology 7, 266-271, doi:10.1159/000353635 (2013).
6 Park, C. H. et al. Suspicious T1 colon cancer with synchronous liver metastasis not detected by preoperative imaging study. Korean J Clin Oncol 15, 135-140, doi:10.14216/kjco.19024 (2019).
7 Wang, H. S. et al. Curative resection of T1 colorectal carcinoma: risk of lymph node metastasis and long-term prognosis. Diseases of the colon and rectum 48, 1182-1192, doi:10.1007/s10350-004-0935-y (2005).
8 Nascimbeni, R., Burgart, L. J., Nivatvongs, S. & Larson, D. R. Risk of lymph node metastasis in T1 carcinoma of the colon and rectum. Diseases of the colon and rectum 45, 200-206, doi:10.1007/s10350-004-6147-7 (2002).
9 Sakuragi, M. et al. Predictive factors for lymph node metastasis in T1 stage colorectal carcinomas. Diseases of the colon and rectum 46, 1626-1632, doi:10.1007/BF02660767 (2003).
10 Duffy, M. J. et al. Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update. Int J Cancer 134, 2513-2522, doi:10.1002/ijc.28384 (2014).
11 Lee, J. H. & Lee, S. W. The Roles of Carcinoembryonic Antigen in Liver Metastasis and Therapeutic Approaches. Gastroenterology research and practice 2017, 7521987, doi:10.1155/2017/7521987 (2017).
12 Quirke, P. et al. The future of the TNM staging system in colorectal cancer: time for a debate? The Lancet. Oncology 8, 651-657, doi:10.1016/S1470-2045(07)70205-X (2007).
13 Nagtegaal, I. D. & Quirke, P. Colorectal tumour deposits in the mesorectum and pericolon; a critical review. Histopathology 51, 141-149, doi:10.1111/j.1365-2559.2007.02720.x (2007).
14 Ueno, H. et al. Actual status of distribution and prognostic impact of extramural discontinuous cancer spread in colorectal cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 29, 2550-2556, doi:10.1200/JCO.2010.33.7725 (2011).
15 Zheng, K. et al. The Prognostic Significance of Tumor Deposit Count for Colorectal Cancer Patients after Radical Surgery. Gastroenterology research and practice 2020, 2052561, doi:10.1155/2020/2052561 (2020).
16 Park, J. S. et al. Prognostic comparison between mucinous and nonmucinous adenocarcinoma in colorectal cancer. Medicine (Baltimore) 94, e658, doi:10.1097/MD.0000000000000658 (2015).
17 Chen, J. S. et al. Clinical outcome of signet ring cell carcinoma and mucinous adenocarcinoma of the colon. Chang Gung Med J 33, 51-57 (2010).
18 Mekenkamp, L. J. et al. Mucinous adenocarcinomas: poor prognosis in metastatic colorectal cancer. Eur J Cancer 48, 501-509, doi:10.1016/j.ejca.2011.12.004 (2012).
19 Numata, M. et al. The clinicopathological features of colorectal mucinous adenocarcinoma and a therapeutic strategy for the disease. World J Surg Oncol 10, 109, doi:10.1186/1477-7819-10-109 (2012).
20 Maisano, R. et al. Mucinous histology of colon cancer predicts poor outcomes with FOLFOX regimen in metastatic colon cancer. J Chemother 24, 212-216, doi:10.1179/1973947812Y.0000000013 (2012).
21 Catalano, V. et al. Prognosis of mucinous histology for patients with radically resected stage II and III colon cancer. Ann Oncol 23, 135-141, doi:10.1093/annonc/mdr062 (2012).
22 Dai, D., Zhou, B., Zhong, Y., Jin, H. & Wang, X. Survival of patients with resected primary colorectal mucinous adenocarcinoma: A competing risk nomogram analysis. Oncol Lett 18, 6594-6604, doi:10.3892/ol.2019.11024 (2019).
23 Chen, S. H. et al. Perineural invasion of cancer: a complex crosstalk between cells and molecules in the perineural niche. American journal of cancer research 9, 1-21 (2019).
24 Zare-Bandamiri, M., Fararouei, M., Zohourinia, S., Daneshi, N. & Dianatinasab, M. Risk Factors Predicting Colorectal Cancer Recurrence Following Initial Treatment: A 5-year Cohort Study. Asian Pacific journal of cancer prevention : APJCP 18, 2465-2470, doi:10.22034/APJCP.2017.18.9.2465 (2017).
25 Quintana, J. M. et al. Predictors of 1- and 2-year mortality in patients with rectal cancer. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20, 676-687, doi:10.1111/codi.14250 (2018).
26 Huang, Y. et al. Individualized prediction of perineural invasion in colorectal cancer: development and validation of a radiomics prediction model. Chinese journal of cancer research = Chung-kuo yen cheng yen chiu 30, 40-50, doi:10.21147/j.issn.1000-9604.2018.01.05 (2018).
27 Compton, C. C. et al. Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999. Archives of pathology & laboratory medicine 124, 979-994, doi:10.1043/0003-9985(2000)124<0979:PFICC>2.0.CO;2 (2000).
28 Sarli, L. et al. Number of lymph nodes examined and prognosis of TNM stage II colorectal cancer. Eur J Cancer 41, 272-279, doi:10.1016/j.ejca.2004.10.010 (2005).
29 Chang, G. J., Rodriguez-Bigas, M. A., Skibber, J. M. & Moyer, V. A. Lymph node evaluation and survival after curative resection of colon cancer: systematic review. Journal of the National Cancer Institute 99, 433-441, doi:10.1093/jnci/djk092 (2007).
30 Bui, L., Rempel, E., Reeson, D. & Simunovic, M. Lymph node counts, rates of positive lymph nodes, and patient survival for colon cancer surgery in Ontario, Canada: a population-based study. Journal of surgical oncology 93, 439-445, doi:10.1002/jso.20499 (2006).
31 Wong, S. L. et al. Hospital lymph node examination rates and survival after resection for colon cancer. JAMA 298, 2149-2154, doi:10.1001/jama.298.18.2149 (2007).
32 Engstrom PF, Arnoletti JP & 3rd, B. A. Engstrom PF, Arnoletti JP, Benson AB 3rd et al. (2012) The NCCN clinical practice guidelines in oncology, version 4.2012. Available at: http://www.nccn.org/professionals/physician_gls/pdf/rectal.pdf.
33 Ganapathi, A. M. et al. Adjuvant chemotherapy for t1 node-positive colon cancers provides significant survival benefit. Diseases of the colon and rectum 57, 1341-1348, doi:10.1097/DCR.0000000000000245 (2014).
34 Vatandoust, S., Price, T. J. & Karapetis, C. S. Colorectal cancer: Metastases to a single organ. World journal of gastroenterology 21, 11767-11776, doi:10.3748/wjg.v21.i41.11767 (2015).
35 Fong, Y., Fortner, J., Sun, R. L., Brennan, M. F. & Blumgart, L. H. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Annals of surgery 230, 309-318; discussion 318-321, doi:10.1097/00000658-199909000-00004 (1999).
36 Kuchel, A. et al. Trends in epidemiology, treatment and molecular testing of metastatic colorectal cancer in a real-world multi-institution cohort study. Asia Pac J Clin Oncol, doi:10.1111/ajco.13420 (2020).
37 Prasanna, T. et al. Metastasectomy and BRAF mutation; an analysis of survival outcome in metastatic colorectal cancer. Curr Probl Cancer, 100637, doi:10.1016/j.currproblcancer.2020.100637 (2020).
38 Reddy, S. K. et al. Simultaneous resections of colorectal cancer and synchronous liver metastases: a multi-institutional analysis. Annals of surgical oncology 14, 3481-3491, doi:10.1245/s10434-007-9522-5 (2007).
39 Kang, H., O'Connell, J. B., Maggard, M. A., Sack, J. & Ko, C. Y. A 10-year outcomes evaluation of mucinous and signet-ring cell carcinoma of the colon and rectum. Diseases of the colon and rectum 48, 1161-1168, doi:10.1007/s10350-004-0932-1 (2005).
40 Oweira, H., Mehrabi, A., Reissfelder, C. & Abdel-Rahman, O. A Real-World, Population-Based Analysis of the Outcomes of Colorectal Cancer Patients with Isolated Synchronous Liver or Lung Metastases Treated with Metastasectomy. World journal of surgery 44, 1604-1611, doi:10.1007/s00268-019-05353-9 (2020).