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Research Article
Qinghuai Liu
The First Affiliated Hospital of Nanjing Medical University
Corresponding Author
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Aim: To describe the changes of optical coherence tomography angiography (OCTA) characteristics in severe non-proliferative Diabetic Retinopathy(S-NPDR) eyes. And study the effect of Panretinal photocoagulation(PRP) on these characteristics.
Methods: This is a prospective study including 31 eyes from 18 consecutive patients with S-NPDR and 31 eyes of healthy subjects. We measured macular vascular density (VD) and foveal avascular zone(FAZ) area by an OCTA device. All patients with S-NPDR underwent PRP treatment. In S-NPDR eyes, the VD and foveal avascular zone(FAZ) area were assessed at 1 week before PRP, 1 month, 3 months and 6 months following PRP.
Results: Compared with the normal control group ,in superficial retinal capillary plexus (SCP), macular VD decreased in S-NPDR group expect foveal VD. In foveal ,p=0.7;In parafoveal and perifoveal, p＜0.001. In deep retinal capillary plexus (DCP), macular VD was also lower in S-NPDR group. In foveal, p=0.01.In parafoveal and perifoveal, p＜0.001. And FAZ area expanded in S-NPDR eyes(p=0.05). In S-NPDR eyes , at 3 months after PRP, foveal VD in DCP increased significantly(p=0.04). At 6 months after PRP, foveal VD increased both in SCP and DCP (P=0.01,P=0.008,respectively). At 6 months after PRP,FAZ area decreased (p=0.04).
Conclusions : Patients with S-NPDR have retinal microcirculation disorder, and PRP can partially improve the macular microcirculation. VD and FAZ can be used as sensitive indicators for follow-up observation of diabetic retinopathy.
Keywords
optical coherence tomography angiography, diabetic retinopathy, Panretinal photocoagulation, vascular density
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Qinghuai Liu
The First Affiliated Hospital of Nanjing Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 09 Dec, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Ophthalmology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Aim: To describe the changes of optical coherence tomography angiography (OCTA) characteristics in severe non-proliferative Diabetic Retinopathy(S-NPDR) eyes. And study the effect of Panretinal photocoagulation(PRP) on these characteristics.
Methods: This is a prospective study including 31 eyes from 18 consecutive patients with S-NPDR and 31 eyes of healthy subjects. We measured macular vascular density (VD) and foveal avascular zone(FAZ) area by an OCTA device. All patients with S-NPDR underwent PRP treatment. In S-NPDR eyes, the VD and foveal avascular zone(FAZ) area were assessed at 1 week before PRP, 1 month, 3 months and 6 months following PRP.
Results: Compared with the normal control group ,in superficial retinal capillary plexus (SCP), macular VD decreased in S-NPDR group expect foveal VD. In foveal ,p=0.7;In parafoveal and perifoveal, p＜0.001. In deep retinal capillary plexus (DCP), macular VD was also lower in S-NPDR group. In foveal, p=0.01.In parafoveal and perifoveal, p＜0.001. And FAZ area expanded in S-NPDR eyes(p=0.05). In S-NPDR eyes , at 3 months after PRP, foveal VD in DCP increased significantly(p=0.04). At 6 months after PRP, foveal VD increased both in SCP and DCP (P=0.01,P=0.008,respectively). At 6 months after PRP,FAZ area decreased (p=0.04).
Conclusions : Patients with S-NPDR have retinal microcirculation disorder, and PRP can partially improve the macular microcirculation. VD and FAZ can be used as sensitive indicators for follow-up observation of diabetic retinopathy.
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