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Research article
Cheuk Chun Szeto
The Chinese University of Hong Kong
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8898-8505
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Nephrology.
Background Depression and frailty contribute to the adverse clinical outcome of peritoneal dialysis (PD) patients. However, the interaction between depression and frailty in PD patients remains uncertain. We determined the prevalence of depression and frailty in prevalent Chinese PD patients, dissected the internal relationship between depression and frailty, and determined their relative contribution to the adverse clinical outcome in PD patients.
Methods In a prospective observational study, we recruited 267 prevalent PD patients. Depression was identified by Patient Health Questionnaire (PHQ-9). Frailty was identified by a validated Frailty Score. All cases were followed for one year. Outcome measures included number and duration of hospitalization, peritonitis rate, and all-cause mortality.
Results Of the 267 patients, 197 patients (73.8%) were depressed, and 157 (58.8%) were frail. There was a substantial overlap between depression and frailty. Although depression and frailty were associated the number and duration of hospitalization by univariate analysis, the association became insignificant after adjusting for confounding factors by multivariate analysis. Both depression and frailty were associated with one-year mortality by univariate analysis. One-year patient survival was 95.9%, 86.5%, 82.4% and 71.0% for patients with nil, mild, moderate and severe frailty, respectively (p = 0.001). Frailty was an independent predictor of patient survival by multivariate analysis (adjusted hazard ratio 1.424, 95% confidence interval 1.011-2.005. p = 0.043), while the prognostic effect of depression disappears after adjusting for frailty score.
Conclusion Depression and frailty were common among Chinese PD patients. Frailty, but not depression, was an independent predictor of one-year mortality.
Keywords
depression, frailty, peritoneal dialysis, PD, adverse outcome
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CURRENT STATUS: Published
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Posted 07 Jul, 2020
Published
On 05 Aug, 2020
No community comments so far
Review #1 received
Received 21 Jul, 2020
Review #2 received
Received 15 Jul, 2020
Reviewer #2 agreed
On 10 Jul, 2020
Reviewers invited
Invitations sent on 07 Jul, 2020
Reviewer #1 agreed
On 07 Jul, 2020
Editor assigned
On 06 Jul, 2020
Submission checks complete
On 05 Jul, 2020
Editor invited
On 05 Jul, 2020
No comments provided
Editorial decision: Major revision
On 16 Jun, 2020
Review #2 received
Received 08 Jun, 2020
Reviewer #2 agreed
On 28 May, 2020
Review #1 received
Received 08 May, 2020
Reviewer #1 agreed
On 27 Feb, 2020
Reviewers invited
Invitations sent on 24 Feb, 2020
Editor assigned
On 21 Feb, 2020
Submission checks complete
On 16 Jan, 2020
Editor invited
On 16 Jan, 2020
First submitted
On 23 Dec, 2019
Metrics
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PDF Downloads: ...
HTML Views: ...
Subject Areas
Urology & Nephrology
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This preprint is under consideration at BMC Nephrology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Cheuk Chun Szeto
The Chinese University of Hong Kong
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8898-8505
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 2
Posted 07 Jul, 2020
Published
On 05 Aug, 2020
No community comments so far
Review #1 received
Received 21 Jul, 2020
Review #2 received
Received 15 Jul, 2020
Reviewer #2 agreed
On 10 Jul, 2020
Reviewers invited
Invitations sent on 07 Jul, 2020
Reviewer #1 agreed
On 07 Jul, 2020
Editor assigned
On 06 Jul, 2020
Submission checks complete
On 05 Jul, 2020
Editor invited
On 05 Jul, 2020
No comments provided
Editorial decision: Major revision
On 16 Jun, 2020
Review #2 received
Received 08 Jun, 2020
Reviewer #2 agreed
On 28 May, 2020
Review #1 received
Received 08 May, 2020
Reviewer #1 agreed
On 27 Feb, 2020
Reviewers invited
Invitations sent on 24 Feb, 2020
Editor assigned
On 21 Feb, 2020
Submission checks complete
On 16 Jan, 2020
Editor invited
On 16 Jan, 2020
First submitted
On 23 Dec, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Urology & Nephrology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Nephrology.
Background Depression and frailty contribute to the adverse clinical outcome of peritoneal dialysis (PD) patients. However, the interaction between depression and frailty in PD patients remains uncertain. We determined the prevalence of depression and frailty in prevalent Chinese PD patients, dissected the internal relationship between depression and frailty, and determined their relative contribution to the adverse clinical outcome in PD patients.
Methods In a prospective observational study, we recruited 267 prevalent PD patients. Depression was identified by Patient Health Questionnaire (PHQ-9). Frailty was identified by a validated Frailty Score. All cases were followed for one year. Outcome measures included number and duration of hospitalization, peritonitis rate, and all-cause mortality.
Results Of the 267 patients, 197 patients (73.8%) were depressed, and 157 (58.8%) were frail. There was a substantial overlap between depression and frailty. Although depression and frailty were associated the number and duration of hospitalization by univariate analysis, the association became insignificant after adjusting for confounding factors by multivariate analysis. Both depression and frailty were associated with one-year mortality by univariate analysis. One-year patient survival was 95.9%, 86.5%, 82.4% and 71.0% for patients with nil, mild, moderate and severe frailty, respectively (p = 0.001). Frailty was an independent predictor of patient survival by multivariate analysis (adjusted hazard ratio 1.424, 95% confidence interval 1.011-2.005. p = 0.043), while the prognostic effect of depression disappears after adjusting for frailty score.
Conclusion Depression and frailty were common among Chinese PD patients. Frailty, but not depression, was an independent predictor of one-year mortality.
Figure 1
Figure 2
Figure 3
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