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Research Article
Masanao Nakamura
Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine
Corresponding Author
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BACKGROUND
Crohn’s disease (CD) can involve the upper gastrointestinal (GI) tract as well as the small and large bowel. PillCam colon capsule endoscopy (PCCE-2) enables to observe the whole GI tract, but its diagnostic yield for CD lesions in the whole GI tract remains unknown.
AIM
To elucidate the diagnostic yield of PCCE-2 in patients with CD.
METHODS
Patients with CD who underwent PCCE-2 and double-balloon endoscopy (DBE) using oral and anal approaches were evaluated for CD lesions in the whole GI tract. We divided the small bowel into three segments (jejunum, ileum, and terminal ileum), and the large bowel into four segments (right colon, transverse colon, left colon, rectum). Detection of ulcer scars, erosion, ulcers, bamboo joint-like appearance, and notch-like appearance was assessed in each segment. The diagnostic yield of PCCE-2 was analyzed based on the DBE results as the gold standard.
RESULTS
Of the total 124 segments, the sensitivities of PCCE-2 for ulcer scars, erosion, and ulcers were 83.3%, 93.8%, and 88.5%, respectively, and the specificities were 76.0%, 78.3%, and 81.6%, respectively. For the 60 small bowel segments, the sensitivities were 84.2%, 95.5%, and 90.0%, respectively, and the specificities were 63.4%, 86.8%, and 87.5%, respectively. For the 64 large bowel segments, the sensitivities were 80.0%, 90.0%, and 83.3%, respectively, and the specificities were 84.7%, 72.2%, and 77.6%, respectively.
CONCLUSION
PCCE-2 provides a high diagnostic yield for lesions in the whole GI tract of patients with CD. Thus, we recommend its use as a pan-enteric tool in clinical settings.
Keywords
Colon capsule endoscopy, Crohn’s disease, Diagnostic yield, Retention, Whole gastrointestinal tract, Prospective study
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CURRENT STATUS: Published
View the published article at BMC Gastroenterology.
Version 1
Posted 09 Dec, 2020
No community comments so far
Editorial decision: Major revision
On 23 Dec, 2020
Reviews received
Received 12 Dec, 2020
Reviewers agreed
On 05 Dec, 2020
Reviewers invited
Invitations sent on 04 Dec, 2020
Editor assigned
On 04 Dec, 2020
Editor invited
On 04 Dec, 2020
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On 04 Dec, 2020
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Subject Areas
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See the published version of this preprint at BMC Gastroenterology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Masanao Nakamura
Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Gastroenterology.
Version 1
Posted 09 Dec, 2020
No community comments so far
Editorial decision: Major revision
On 23 Dec, 2020
Reviews received
Received 12 Dec, 2020
Reviewers agreed
On 05 Dec, 2020
Reviewers invited
Invitations sent on 04 Dec, 2020
Editor assigned
On 04 Dec, 2020
Editor invited
On 04 Dec, 2020
Submission checks complete
On 04 Dec, 2020
First submitted
On 01 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Gastroenterology & Hepatology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Gastroenterology.
BACKGROUND
Crohn’s disease (CD) can involve the upper gastrointestinal (GI) tract as well as the small and large bowel. PillCam colon capsule endoscopy (PCCE-2) enables to observe the whole GI tract, but its diagnostic yield for CD lesions in the whole GI tract remains unknown.
AIM
To elucidate the diagnostic yield of PCCE-2 in patients with CD.
METHODS
Patients with CD who underwent PCCE-2 and double-balloon endoscopy (DBE) using oral and anal approaches were evaluated for CD lesions in the whole GI tract. We divided the small bowel into three segments (jejunum, ileum, and terminal ileum), and the large bowel into four segments (right colon, transverse colon, left colon, rectum). Detection of ulcer scars, erosion, ulcers, bamboo joint-like appearance, and notch-like appearance was assessed in each segment. The diagnostic yield of PCCE-2 was analyzed based on the DBE results as the gold standard.
RESULTS
Of the total 124 segments, the sensitivities of PCCE-2 for ulcer scars, erosion, and ulcers were 83.3%, 93.8%, and 88.5%, respectively, and the specificities were 76.0%, 78.3%, and 81.6%, respectively. For the 60 small bowel segments, the sensitivities were 84.2%, 95.5%, and 90.0%, respectively, and the specificities were 63.4%, 86.8%, and 87.5%, respectively. For the 64 large bowel segments, the sensitivities were 80.0%, 90.0%, and 83.3%, respectively, and the specificities were 84.7%, 72.2%, and 77.6%, respectively.
CONCLUSION
PCCE-2 provides a high diagnostic yield for lesions in the whole GI tract of patients with CD. Thus, we recommend its use as a pan-enteric tool in clinical settings.
Figure 1
Figure 1
Figure 2
Figure 2
Figure 3
Figure 3
This is a list of supplementary files associated with this preprint. Click to download.
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