Complete Genome Sequence of Unusual Strain of Zika Virus From West Africa

doi:10.21203/rs.3.rs-1203528/v1

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Complete Genome Sequence of Unusual Strain of Zika Virus From West Africa

https://doi.org/10.21203/rs.3.rs-1203528/v1

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In 2018, a Zika infection was detected in patients in the Republic of Guinea. We determined the complete genome sequence of the Faranah/18 strain of Zika virus (ZIKV) isolated using C6/36 cells. The genome sequences are significantly different from those of other African ZIKVs. This isolate has 13 aa substitutions in nonstructural polypeptides, an additional glycosylation site on protein E, and unusual localization of MSI1 binding sites in the 3’-UTR of the African lineage. Additionally, Faranah/18 formed a separate lineage into African genotypes with divergence times near 94 and 646-861 years from Senegal and Uganda ZIKVs, respectively.

Zika virus

Faranah/18 strain

African genotype

genome sequence

MSI1 sites

glycosylation site

3’-UTR

Acknowledgements The authors would like to gratefully acknowledge support from the Ministry of Science and Higher Education of the Russian Federation (Agreements # 075-15-2019-1665).

Compliance with ethical standards I have read and abided by the statement of ethical standards for manuscripts submitted to Archives of Virology.

Conflict of interest All authors declare they have no conflict of interest.

Ethical approval This article does not contain any studies with human participants or animals performed by any of the authors.

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Editorial decision: Minor Revision
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First submitted to journal
24 Dec, 2021

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Complete Genome Sequence of Unusual Strain of Zika Virus From West Africa

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