ALFF:
In the comparison of ALFF value between amputation patients and control normal, we found that the ALFF value increased in Cingulate_Ant, ParaHippocampal, Hippocampus, Cingulate_Mid, Supp_Motor_Area, Insula, Putamen, Postcentral, Insula, Caudate, Hippocampus; decreased in Precuneus, Precentral, Occipital_Mid, Postcentral, Supp_Motor_Area, Paracentral_Lobule at 2 months. (Figure 1, Table 1)
Table 1: Brain region information of ALFF comparison between amputation patients and control normal at 2 months:
Contrast Name
|
|
|
MNI Coordinates
|
|
Region Label
|
Extent
|
t-value
|
x
|
y
|
z
|
|
|
|
|
|
|
|
Positive
|
Cingulate_Ant_R
|
100
|
3.295
|
3
|
27
|
0
|
|
ParaHippocampal_R
|
49
|
4.258
|
18
|
0
|
-21
|
|
Hippocampus_L
|
189
|
4.257
|
-21
|
-27
|
-12
|
|
ParaHippocampal_L
|
189
|
3.452
|
-21
|
-9
|
-30
|
|
Supp_Motor_Area_L
|
8
|
3.729
|
-3
|
21
|
54
|
|
Insula_R
|
19
|
3.583
|
42
|
-9
|
-9
|
|
Putamen_L
|
34
|
3.489
|
-27
|
-15
|
3
|
|
Postcentral_L
|
11
|
3.414
|
-63
|
-21
|
18
|
|
Putamen_R
|
16
|
3.334
|
27
|
3
|
-3
|
Negative
|
Precuneus_R
|
51
|
-4.492
|
6
|
-66
|
54
|
|
Precentral_R
|
97
|
-4.332
|
42
|
-12
|
57
|
|
Precentral_L
|
51
|
-4.128
|
-27
|
0
|
60
|
|
Postcentral_R
|
44
|
-3.836
|
27
|
-42
|
63
|
|
Postcentral_L
|
19
|
-3.758
|
-21
|
-45
|
69
|
|
Supp_Motor_Area_R
|
42
|
-3.705
|
3
|
-15
|
72
|
The ALFF value increased in Putamen, Caudate, Hippocampus, Supp_Motor_Area, Lingual, ParaHippocampal, Precuneus, Cingulate_Mid, Cingulate_Ant, Parietal_Inf, Caudate; decreased in Paracentral_Lobule, Supp_Motor_Area, Precentral, Cuneus, Precuneus, Fusiform, Postcentral at 6 months. (Figure 2, Table 2)
Table 2: Brain region information of ALFF comparison between amputation patients and control normal at 6 months:
Contrast Name
|
|
|
MNI Coordinates
|
|
Region Label
|
Extent
|
t-value
|
x
|
y
|
z
|
|
|
|
|
|
|
|
Positive
|
Putamen_L
|
88
|
4.993
|
-21
|
-3
|
3
|
|
Caudate_R
|
17
|
3.924
|
15
|
15
|
3
|
|
Hippocampus_L
|
36
|
3.804
|
-30
|
-21
|
-21
|
|
Supp_Motor_Area_L
|
10
|
3.521
|
-3
|
24
|
54
|
|
Putamen_R
|
11
|
3.386
|
24
|
6
|
-6
|
Negative
|
Paracentral_Lobule_L
|
903
|
-6.797
|
-15
|
-36
|
63
|
|
Supp_Motor_Area_R
|
903
|
-5.979
|
6
|
-6
|
60
|
|
Precentral_R
|
30
|
-5.233
|
48
|
-3
|
42
|
|
Lingual_R
|
428
|
-5.184
|
6
|
-72
|
-9
|
|
Cuneus_R
|
428
|
-4.449
|
9
|
-81
|
24
|
|
Precuneus_R
|
86
|
-5.020
|
15
|
-66
|
39
|
|
Fusiform_R
|
47
|
-3.948
|
24
|
9
|
-45
|
|
Temporal_Inf_R
|
27
|
-3.210
|
42
|
-57
|
-9
|
The ALFF value increased in Cingulate_Ant, Cingulate_Mid, Caudate, Precuneus, Supp_Motor_Area, Frontal_Sup_Media, Insula, Thalamus, Putamen; decreased in Precentral, Postcentral, Supp_Motor_Area, Precuneus, Paracentral_Lobule. (Figure 3, Table 3)
Table 3: Brain region information of ALFF comparison between amputation patients and control normal at 12 months:
Contrast Name
|
|
|
MNI Coordinates
|
|
Region Label
|
Extent
|
t-value
|
x
|
y
|
z
|
|
|
|
|
|
|
|
Positive
|
Cingulate_Mid_R
|
30
|
6.424
|
12
|
-33
|
42
|
|
Caudate_R
|
18
|
5.593
|
21
|
-3
|
18
|
|
Precuneus_L
|
28
|
4.674
|
-9
|
-69
|
60
|
|
Caudate_R
|
202
|
3.910
|
15
|
12
|
3
|
|
Rectus_L
|
202
|
3.835
|
3
|
30
|
-18
|
|
Pallidum_L
|
25
|
4.531
|
-21
|
-3
|
0
|
|
Supp_Motor_Area_L
|
16
|
4.509
|
-3
|
21
|
54
|
|
Cingulate_Mid_L
|
95
|
4.198
|
-12
|
-42
|
42
|
|
Hippocampus_R
|
14
|
4.155
|
36
|
-30
|
-6
|
|
Frontal_Sup_Medial_R
|
41
|
3.936
|
6
|
57
|
27
|
|
Insula_R
|
10
|
3.873
|
39
|
-18
|
0
|
|
Cingulate_Ant_R
|
69
|
3.100
|
3
|
18
|
21
|
|
Thalamus_R
|
30
|
3.805
|
15
|
-9
|
-3
|
|
Occipital_Mid_R
|
24
|
3.614
|
51
|
-66
|
24
|
|
Putamen_L
|
12
|
3.368
|
-27
|
-15
|
3
|
|
ParaHippocampal_L
|
32
|
3.362
|
-27
|
-39
|
-12
|
Negative
|
Precentral_R
|
29
|
-6.454
|
30
|
-21
|
63
|
|
Lingual_R
|
476
|
-6.267
|
18
|
-63
|
-6
|
|
Postcentral_R
|
41
|
-6.032
|
27
|
-42
|
63
|
|
Supp_Motor_Area_R
|
25
|
-5.477
|
3
|
-9
|
57
|
|
Fusiform_R
|
102
|
-5.381
|
24
|
3
|
-45
|
|
Lingual_L
|
67
|
-3.192
|
-12
|
-75
|
-6
|
|
Precuneus_R
|
55
|
-4.646
|
24
|
-45
|
6
|
|
Precentral_L
|
26
|
-4.588
|
-21
|
-18
|
63
|
|
Paracentral_Lobule_L
|
13
|
-3.299
|
-18
|
-30
|
66
|
DC:
In the comparison of DC between amputation patients and control normal, we found that the DC value increased in Rolandic_Oper, Postcentral, Calcarine, Parietal, Cingulate_Mid, Frontal_Med_Orb, Frontal_Sup_Medial; decreased in Precuneus, ParaHippocampal, Caudate, Frontal_Inf_Tri, Precentral, Postcentral at 2months. (Figure 4, Table 4)
Table 4: Brain region information of DC comparison between amputation patients and control normal at 2 months:
Contrast Name
|
|
|
MNI Coordinates
|
|
Region Label
|
Extent
|
t-value
|
x
|
y
|
z
|
|
|
|
|
|
|
|
Positive
|
Rolandic_Oper_L
|
11
|
4.459
|
-63
|
-3
|
12
|
|
Postcentral_L
|
10
|
3.603
|
-63
|
-21
|
27
|
|
Cingulate_Mid_L
|
27
|
3.373
|
-6
|
12
|
39
|
|
Frontal_Med_Orb_R
|
12
|
3.290
|
9
|
42
|
-12
|
Negative
|
Precuneus_R
|
105
|
-4.736
|
15
|
-48
|
21
|
|
ParaHippocampal_R
|
105
|
-3.788
|
18
|
-39
|
-6
|
|
Caudate_R
|
23
|
-4.711
|
21
|
24
|
-6
|
|
Occipital_Mid_L
|
18
|
-4.159
|
-27
|
-78
|
0
|
|
Frontal_Inf_Tri_R
|
10
|
-3.876
|
51
|
24
|
6
|
|
Precuneus_L
|
23
|
-3.808
|
-9
|
-60
|
15
|
|
Precentral_R
|
10
|
-3.426
|
60
|
9
|
15
|
The DC value increased in Cuneus, Calcarine, Postcentral, Parietal_Inf, ParaHippocampal; decreased in Cingulate_Mid, Precuneus, Hippocampus, Precuneus, ParaHippocampal, Caudate, Postcentral at 6 months. (Figure 5, Table 5)
Table 5: Brain region information of DC comparison between amputation patients and control normal at 6 months:
Contrast Name
|
|
|
MNI Coordinates
|
|
Region Label
|
Extent
|
t-value
|
x
|
y
|
z
|
|
|
|
|
|
|
|
Positive
|
Cuneus_L
|
19
|
6.229
|
0
|
-90
|
33
|
|
Calcarine_R
|
103
|
5.182
|
18
|
-99
|
0
|
|
Postcentral_L
|
9
|
4.074
|
-63
|
-21
|
24
|
|
ParaHippocampal_L
|
14
|
3.290
|
-18
|
3
|
-33
|
|
Postcentral_R
|
6
|
3.138
|
45
|
-42
|
63
|
Negative
|
Cingulate_Mid_R
|
14
|
-5.296
|
12
|
-6
|
39
|
|
Precuneus_R
|
31
|
-4.937
|
21
|
-51
|
18
|
|
Hippocampus_R
|
15
|
-4.685
|
27
|
-21
|
-15
|
|
Precuneus_L
|
15
|
-4.310
|
-3
|
-54
|
69
|
|
ParaHippocampal_R
|
27
|
-4.193
|
21
|
-39
|
-6
|
|
Caudate_R
|
5
|
-4.040
|
21
|
24
|
-6
|
|
Cingulate_Mid_L
|
11
|
-3.602
|
-12
|
-33
|
42
|
|
Postcentral_L
|
6
|
-3.025
|
-30
|
-33
|
54
|
The DC value increased in Lingual, Cuneus, Caudate, Fusiform, Postcentral, Frontal_Med_Or; decreased in ParaHippocampal, Precuneus, Cingulate_Post, Precuneus, Frontal_Inf_Tri, Frontal_Inf_Oper, Frontal_Med_Orb, Fusiform, Lingual, Putamen, Lingual at 12 months. (Figure 6, Table 6)
Table 6: Brain region information of DC comparison between amputation patients and control normal at 12 months:
Contrast Name
|
|
|
MNI Coordinates
|
|
Region Label
|
Extent
|
t-value
|
x
|
y
|
z
|
|
|
|
|
|
|
|
Positive
|
Lingual_R
|
188
|
6.163
|
24
|
-93
|
-15
|
|
Cuneus_R
|
188
|
5.813
|
18
|
-99
|
9
|
|
Caudate_L
|
12
|
4.725
|
-12
|
-3
|
15
|
|
Fusiform_L
|
23
|
4.308
|
-21
|
3
|
-45
|
|
Postcentral_L
|
10
|
4.030
|
-21
|
-30
|
78
|
|
Parietal_Inf_R
|
21
|
3.916
|
45
|
-39
|
54
|
Negative
|
ParaHippocampal_R
|
162
|
-8.290
|
21
|
-39
|
-6
|
|
Precuneus_R
|
162
|
-4.969
|
12
|
-63
|
24
|
|
Cingulate_Post_L
|
56
|
-6.593
|
-6
|
-39
|
12
|
|
Precuneus_L
|
25
|
-5.595
|
-6
|
-60
|
15
|
|
Frontal_Inf_Tri_R
|
16
|
-5.115
|
51
|
24
|
6
|
|
Fusiform_R
|
47
|
-4.827
|
39
|
-33
|
-18
|
|
Frontal_Inf_Oper_R
|
20
|
-4.427
|
36
|
6
|
27
|
|
Putamen_R
|
12
|
-3.446
|
30
|
-6
|
6
|