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Research Article
Poemen Chan
Chinese University of Hong Kong
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose: To investigate the peripapillary vascular metrics in early normal tension glaucoma (NTG) and early primary angle closure glaucoma (PACG) eyes using optical coherence tomography angiography (OCT-A).
Methods: One or both eyes of each subjects were imaged for a 3x3mm peripapillary region by swept-source OCT-A (DRI-OCT Triton, Topcon, Japan) and assessed by an automated MATLAB program. OCT-A metrics including circumpapillary vessel density (cpVD) and fractal dimension (cpFD) were compared. Their association with visual field (VF) parameters and retinal nerve fiber layer (RNFL) thickness were determined.
Results: Sixty-eight eyes of 51 PACG, 68 eyes of 48 NTG, and 68 eyes of 49 control subjects were cross-sectionally analyzed. NTG eyes had significantly lower global cpVD (52.369±0.781%) compared with PACG eyes (55.389±0.721%, P=0.004) that had comparable disease severity and average RNFL thickness. Multivariable analysis reviewed that, for PACG and NTG eyes, decreased cpVD ([PACG] β=-4.242; CI:-8.120, -0.363 vs [NTG] β=-5.531; CI:-9.472, -1.590) and cpFD ([PACG] β=-8.894;CI:-11.925, -5.864 vs [NTG] β=-12.064; CI:-17.095, -6.932) were associated with decreased RNFL thickness (all P≤0.032); with a stronger association between decrease cpFD and decreased RNFL thickness in NTG eyes (Fisher’s Z-test, P=0.045). Decreased
cpVD was associated with decrease mean deviation (MD) in NTG eyes (β=-0.707; CI:-1.090, -0.324; P≤0.001) and not associated with the visual field parameters in PACG eyes.
Conclusions: Early NTG had lower global cpVD compared with early PACG, despite similar disease severity and average RNFL thickness.
Précis:
Optical coherence tomography angiography observed a lower peripapillary microvascular perfusion in early NTG eyes compared with early PACG eyes, despite similar disease severity and retinal nerve fiber layer thickness.
Keywords
optical coherence tomography angiography, primary angle closure glaucoma, normal tension glaucoma
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CURRENT STATUS: Published
View the published article at Scientific Reports.
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Posted 22 Dec, 2020
No community comments so far
Editorial decision: Major revision
On 05 Apr, 2021
Reviews received
Received 26 Mar, 2021
Reviewers agreed
On 14 Mar, 2021
Reviewers invited
Invitations sent on 14 Mar, 2021
Editor assigned
On 09 Mar, 2021
Editor invited
On 21 Dec, 2020
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On 21 Dec, 2020
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A new preprint design is coming!
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See the published version of this preprint at Scientific Reports.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Poemen Chan
Chinese University of Hong Kong
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Scientific Reports.
Version 1
Posted 22 Dec, 2020
No community comments so far
Editorial decision: Major revision
On 05 Apr, 2021
Reviews received
Received 26 Mar, 2021
Reviewers agreed
On 14 Mar, 2021
Reviewers invited
Invitations sent on 14 Mar, 2021
Editor assigned
On 09 Mar, 2021
Editor invited
On 21 Dec, 2020
Submission checks complete
On 21 Dec, 2020
First submitted
On 03 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Scientific Reports.
Purpose: To investigate the peripapillary vascular metrics in early normal tension glaucoma (NTG) and early primary angle closure glaucoma (PACG) eyes using optical coherence tomography angiography (OCT-A).
Methods: One or both eyes of each subjects were imaged for a 3x3mm peripapillary region by swept-source OCT-A (DRI-OCT Triton, Topcon, Japan) and assessed by an automated MATLAB program. OCT-A metrics including circumpapillary vessel density (cpVD) and fractal dimension (cpFD) were compared. Their association with visual field (VF) parameters and retinal nerve fiber layer (RNFL) thickness were determined.
Results: Sixty-eight eyes of 51 PACG, 68 eyes of 48 NTG, and 68 eyes of 49 control subjects were cross-sectionally analyzed. NTG eyes had significantly lower global cpVD (52.369±0.781%) compared with PACG eyes (55.389±0.721%, P=0.004) that had comparable disease severity and average RNFL thickness. Multivariable analysis reviewed that, for PACG and NTG eyes, decreased cpVD ([PACG] β=-4.242; CI:-8.120, -0.363 vs [NTG] β=-5.531; CI:-9.472, -1.590) and cpFD ([PACG] β=-8.894;CI:-11.925, -5.864 vs [NTG] β=-12.064; CI:-17.095, -6.932) were associated with decreased RNFL thickness (all P≤0.032); with a stronger association between decrease cpFD and decreased RNFL thickness in NTG eyes (Fisher’s Z-test, P=0.045). Decreased
cpVD was associated with decrease mean deviation (MD) in NTG eyes (β=-0.707; CI:-1.090, -0.324; P≤0.001) and not associated with the visual field parameters in PACG eyes.
Conclusions: Early NTG had lower global cpVD compared with early PACG, despite similar disease severity and average RNFL thickness.
Précis:
Optical coherence tomography angiography observed a lower peripapillary microvascular perfusion in early NTG eyes compared with early PACG eyes, despite similar disease severity and retinal nerve fiber layer thickness.
Figure 1
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