Modelling the effect of subcellular mutations on the migration of cells in the colorectal crypt
Background Many cancers arise from mutations in cells in epithelial tissues. Mutations manifesting at the subcellular level influence the structure and function of the tissue. In this paper we present a framework that allows the investigation of the influence of mutations such as subcellular knockouts and knockdowns on migration of cells within epithelial tissues.
Results In particular we investigate how specific mutations may lead to the increase in numbers of cells in the epithelial lining of the colorectal crypt, which may lead to the eventual destabilisation of the structure of the crypt and the onset of colorectal cancer. Secondly, we present the computational tools that allow the straightforward integration, and simulation of, SBML representations of subcellular dynamics with multicellular representations of the colorectal crypt.
Conclusions We see that mutations in APC can cause downward invasion of mutant cells in the crypt.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Due to technical limitations, full-text HTML conversion of this manuscript could not be completed. However, the manuscript can be downloaded and accessed as a PDF.
On 03 Mar, 2020
On 21 Jan, 2020
Received 19 Jan, 2020
On 17 Jan, 2020
On 15 Jan, 2020
Invitations sent on 15 Jan, 2020
On 14 Jan, 2020
On 14 Jan, 2020
On 20 Dec, 2019
Received 19 Dec, 2019
Received 29 Nov, 2019
On 20 Nov, 2019
On 16 Nov, 2019
Invitations sent on 15 Nov, 2019
On 13 Nov, 2019
On 12 Nov, 2019
On 12 Nov, 2019
Posted 04 Sep, 2019
On 16 Sep, 2019
Received 26 Aug, 2019
Received 26 Aug, 2019
On 21 Aug, 2019
On 21 Aug, 2019
Invitations sent on 12 Aug, 2019
On 04 Jun, 2019
On 29 May, 2019
On 29 May, 2019
On 28 May, 2019
Modelling the effect of subcellular mutations on the migration of cells in the colorectal crypt
On 03 Mar, 2020
On 21 Jan, 2020
Received 19 Jan, 2020
On 17 Jan, 2020
On 15 Jan, 2020
Invitations sent on 15 Jan, 2020
On 14 Jan, 2020
On 14 Jan, 2020
On 20 Dec, 2019
Received 19 Dec, 2019
Received 29 Nov, 2019
On 20 Nov, 2019
On 16 Nov, 2019
Invitations sent on 15 Nov, 2019
On 13 Nov, 2019
On 12 Nov, 2019
On 12 Nov, 2019
Posted 04 Sep, 2019
On 16 Sep, 2019
Received 26 Aug, 2019
Received 26 Aug, 2019
On 21 Aug, 2019
On 21 Aug, 2019
Invitations sent on 12 Aug, 2019
On 04 Jun, 2019
On 29 May, 2019
On 29 May, 2019
On 28 May, 2019
Background Many cancers arise from mutations in cells in epithelial tissues. Mutations manifesting at the subcellular level influence the structure and function of the tissue. In this paper we present a framework that allows the investigation of the influence of mutations such as subcellular knockouts and knockdowns on migration of cells within epithelial tissues.
Results In particular we investigate how specific mutations may lead to the increase in numbers of cells in the epithelial lining of the colorectal crypt, which may lead to the eventual destabilisation of the structure of the crypt and the onset of colorectal cancer. Secondly, we present the computational tools that allow the straightforward integration, and simulation of, SBML representations of subcellular dynamics with multicellular representations of the colorectal crypt.
Conclusions We see that mutations in APC can cause downward invasion of mutant cells in the crypt.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Due to technical limitations, full-text HTML conversion of this manuscript could not be completed. However, the manuscript can be downloaded and accessed as a PDF.