This study assessed the impact of repeated biomarker measurements of statistical joint modeling on survival time-to-death and determines potential predictors of HIV/AIDS patients on ART in Mekelle General Hospital Ethiopia. A retrospective cohort study was conducted among HIV/AIDS patients who were under ART follow-up during September 11, 2013 - September 5, 2016, at Mekelle General Hospital, Ethiopia. The relationship between the two biomarkers CD4 cell and body weight with risk for survival time-to-death were statistically insignificant. Thus, death is less probable to occur in HIV/AIDS patients with a higher value of CD4 cell count and body weight progression. In the event process the sub-model, Baseline CD4, Fair, and Good Adherence, HIV/TB, and Sex were significant factors of risk to short survival Time-to-Death on HIV/AIDS patients. In the 1st longitudinal process sub-model, Baseline CD4, Ambulatory functional status, HIV/TB (yes), Time*Ambulatory functional status, Time*Working functional status, and Time*Baseline CD4 were the significant factors of √CD4 Cell count progression. Moreover, In the 2nd longitudinal process sub-model, visit Time of follow-up, Age, Sex (male), Baseline weight, Time*Ambulatory and Time*Working functional status were the significant factors of log 10(bodyweight) progression. Both governmental and non-governmental stakeholders should pay special attention to HIV-positive adults, especially those who had developed HIV/TB, male, bedridden functional status, poor adherence, and lower Baseline CD4 cell count progression so that mortality due to HIV/AIDS optimally reduced.