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Objectives
Previous studies suggested that protein has a protective effect on the formation of biliary stones. The aim of the current study is the comparison between the effect of animal protein and plant protein on the formation of biliary stone. One hundred and ten cases who had the history of biliary stone disease and 230 controls who were normal in terms of biliary diseases enrolled in this study. Food frequency questionnaire was used for the nutritional assessment; moreover, demographic and anthropometric data, in addition to habitual history and comorbidities were collected by a questionnaire.
Results
Plant protein consumption was significantly lower in cases compared to controls (p=0.03). Furthermore, the relationship between biliary stone disease and animal protein intake was significant in crude model for men (OR: 1.03, 95% CI=1.01-1.05) and both sex together (OR: 1.01, 95% CI=1.00-1.01). In addition, the risk of biliary stone was significantly lower in patients with higher consumption of plant protein (for women: OR: 0.94, 95% CI=0.89-0.99, for both sex: OR: 0.96, 95% CI=0.93-0.99). Plant proteins have a significant negative effect on the formation of biliary stone disease compared to animal proteins.
Keywords
Gallstones, Diet, Plant Proteins, Animal Protein
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research note
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 22 Jan, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Gastroenterology & Hepatology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objectives
Previous studies suggested that protein has a protective effect on the formation of biliary stones. The aim of the current study is the comparison between the effect of animal protein and plant protein on the formation of biliary stone. One hundred and ten cases who had the history of biliary stone disease and 230 controls who were normal in terms of biliary diseases enrolled in this study. Food frequency questionnaire was used for the nutritional assessment; moreover, demographic and anthropometric data, in addition to habitual history and comorbidities were collected by a questionnaire.
Results
Plant protein consumption was significantly lower in cases compared to controls (p=0.03). Furthermore, the relationship between biliary stone disease and animal protein intake was significant in crude model for men (OR: 1.03, 95% CI=1.01-1.05) and both sex together (OR: 1.01, 95% CI=1.00-1.01). In addition, the risk of biliary stone was significantly lower in patients with higher consumption of plant protein (for women: OR: 0.94, 95% CI=0.89-0.99, for both sex: OR: 0.96, 95% CI=0.93-0.99). Plant proteins have a significant negative effect on the formation of biliary stone disease compared to animal proteins.
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