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Research article
huafang Li
Shanghai Mental Health Center
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2384-8998
License:
This work is licensed under a CC BY 4.0 License. Read Full License
INTRODUCTION
Glial fibrillary acidic protein (GFAP) is considered to be an astrocyte activation marker. Alterations in structural and functional molecules expressed by astrocytes may play a role in the pathophysiology of schizophrenia (SCZ). In the present study, the single nucleotide polymorphisms (SNPs) of GFAP were analyzed for association with schizophrenia in Han population.
METHODS
Three tag SNPs within GFAP were genotyped in 629 SCZ patients and 655 healthy controls in the Han Chinese population.The schizophrenia database(SCZB) was used to investigate whether GFAP is differentially expressed in the brain regions of schizophrenia and healthy control individuals.In addition, expression quantitative trait loci(eQTL) analysis was used to investigate differential GFAP expression between different genotypes.
RESULTS
It was shown that the rs3785891 GFAP polymorphism may be associated with schizophrenia ( p =0.04). There were no significant differences in the expression of hippocampal, prefrontal cortex or cortical GFAP between schizophrenia patients and control individuals. Furthermore,the brain eQTL analysis revealed a significant association between the rs3785891 polymorphism and GFAP expression in the intralobular white matter ( p = 0.04), thalamus ( p =0.024), hippocampus ( p =0.011), and occipital cortex ( p =0.0075).
CONCLUSIONS
This study shows that rs3785891 may be linked to schizophrenia susceptibility in the Han population. Further study is required for clarification the role of genetic variation around these SNPs in expression pattern of the GFAP gene, which may be involved in schizophrenia pathogenesis.
Keywords
Glial fibrillary acidic protein, schizophrenia, SNP, haplotype, eQTL
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
huafang Li
Shanghai Mental Health Center
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2384-8998
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 23 Jan, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Psychiatry
License:
This work is licensed under a CC BY 4.0 License. Read Full License
INTRODUCTION
Glial fibrillary acidic protein (GFAP) is considered to be an astrocyte activation marker. Alterations in structural and functional molecules expressed by astrocytes may play a role in the pathophysiology of schizophrenia (SCZ). In the present study, the single nucleotide polymorphisms (SNPs) of GFAP were analyzed for association with schizophrenia in Han population.
METHODS
Three tag SNPs within GFAP were genotyped in 629 SCZ patients and 655 healthy controls in the Han Chinese population.The schizophrenia database(SCZB) was used to investigate whether GFAP is differentially expressed in the brain regions of schizophrenia and healthy control individuals.In addition, expression quantitative trait loci(eQTL) analysis was used to investigate differential GFAP expression between different genotypes.
RESULTS
It was shown that the rs3785891 GFAP polymorphism may be associated with schizophrenia ( p =0.04). There were no significant differences in the expression of hippocampal, prefrontal cortex or cortical GFAP between schizophrenia patients and control individuals. Furthermore,the brain eQTL analysis revealed a significant association between the rs3785891 polymorphism and GFAP expression in the intralobular white matter ( p = 0.04), thalamus ( p =0.024), hippocampus ( p =0.011), and occipital cortex ( p =0.0075).
CONCLUSIONS
This study shows that rs3785891 may be linked to schizophrenia susceptibility in the Han population. Further study is required for clarification the role of genetic variation around these SNPs in expression pattern of the GFAP gene, which may be involved in schizophrenia pathogenesis.
Figure 1
Figure 2
Figure 3
Figure 4
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