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Research Article
Afaf El-Ansary
King Saud University
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background:
Obesity is a risk factor for several diseases related to oxidative stress, hyperlipidemia, and hyperglycemia. Several pharmacological agents have been used to treat obesity, but these commonly exhibit undesirable side effects. The aim of this study was to explore the effects of Garcinia mangostana (mangosteen) and Curcuma longa independently and synergistically in modulating selected biochemical markers of oxidative stress, dyslipidemia, and hyperglycemia commonly observed in high-fat diet-induced obesity in rodent models.
Methods:
Male albino Wistar rats were divided into eight experimental groups, fed on a normal diet or high-fat diet (HFD), then given mangosteen extract (400 mg /kg body weight/day) and/or curcumin (80 mg/kg body weight/day) for 6 weeks. Oxidative stress markers, glucose, and lipid fractions were measured in the sera.
Results:
Curcumin was found to be more effective in reducing BMI, while mangosteen extract was found to induce a significant increase in anti-atherogenic marker HDL-C, but was ineffective in reducing dyslipidemia. Mangosteen extract and curcumin effectively reduced blood glucose. Mangosteen did not exhibit any anti-oxidative effects in normal weight rats; however, it induced a significant increase in glutathione in obese rats.
Conclusion:
The present study demonstrated that mangosteen pericarp extract and curcumin were independently and synergistically effective in treating obesity-induced atherogenesis.
Keywords
Garcinia mangostana, Curcuma, Obesity, High fat diet, Oxidative stress, dyslipdemia, hyperglycemia
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CURRENT STATUS: Under Review
Version 1
Posted 15 Jan, 2021
No community comments so far
Editorial decision: Major revision
On 01 Feb, 2021
Reviews received
Received 23 Jan, 2021
Reviewers agreed
On 13 Jan, 2021
Reviewers invited
Invitations sent on 13 Jan, 2021
Editor assigned
On 13 Jan, 2021
Editor invited
On 13 Jan, 2021
Submission checks complete
On 13 Jan, 2021
First submitted
On 05 Dec, 2020
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This preprint is under consideration at Scientific Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Afaf El-Ansary
King Saud University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 15 Jan, 2021
No community comments so far
Editorial decision: Major revision
On 01 Feb, 2021
Reviews received
Received 23 Jan, 2021
Reviewers agreed
On 13 Jan, 2021
Reviewers invited
Invitations sent on 13 Jan, 2021
Editor assigned
On 13 Jan, 2021
Editor invited
On 13 Jan, 2021
Submission checks complete
On 13 Jan, 2021
First submitted
On 05 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background:
Obesity is a risk factor for several diseases related to oxidative stress, hyperlipidemia, and hyperglycemia. Several pharmacological agents have been used to treat obesity, but these commonly exhibit undesirable side effects. The aim of this study was to explore the effects of Garcinia mangostana (mangosteen) and Curcuma longa independently and synergistically in modulating selected biochemical markers of oxidative stress, dyslipidemia, and hyperglycemia commonly observed in high-fat diet-induced obesity in rodent models.
Methods:
Male albino Wistar rats were divided into eight experimental groups, fed on a normal diet or high-fat diet (HFD), then given mangosteen extract (400 mg /kg body weight/day) and/or curcumin (80 mg/kg body weight/day) for 6 weeks. Oxidative stress markers, glucose, and lipid fractions were measured in the sera.
Results:
Curcumin was found to be more effective in reducing BMI, while mangosteen extract was found to induce a significant increase in anti-atherogenic marker HDL-C, but was ineffective in reducing dyslipidemia. Mangosteen extract and curcumin effectively reduced blood glucose. Mangosteen did not exhibit any anti-oxidative effects in normal weight rats; however, it induced a significant increase in glutathione in obese rats.
Conclusion:
The present study demonstrated that mangosteen pericarp extract and curcumin were independently and synergistically effective in treating obesity-induced atherogenesis.
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