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Background Diabetes is mostly assessed by the fasting glucose level. Several studies reported that serum fasting glucose levels are causally associated with MC4R.
Methods A total of 4,294 subjects participated in this study. We used multivariate linear regression models and multiple logistic regression analysis.
Results Individuals with the TC/CC genotype had a 1.29-fold higher risk of diabetes than did those with the TT genotype when adjusting for age, sex, and BMI (OR, 1.29; 95% CI, 1.04-1.60). For healthy subjects, the association was significant in females (OR, 1.99; 95% CI, 1.01-3.93). Male participants with the TC/CC genotype had a 1.21-fold higher risk of cardiovascular disease than did those with the TT genotype when adjusting for age, sex, and BMI (OR, 1.21; 95% CI, 1.04-1.41). The relationship between MC4R and cardiovascular disease was stronger in lean male individuals (OR, 1.40; 95% CI, 1.12–1.74, p = 0.0028) than in obese male subjects.
Conclusions This study suggests that the rs17782313 SNP in MC4R is related to diabetes and the SNP is also associated with cardiovascular disease in lean male individuals.
Keywords
fasting glucose, MC4R, polymorphisms
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CURRENT STATUS: Published
View the published article at BMC Medical Genetics.
No community comments so far
Submission checks complete
On 04 Aug, 2020
Editorial decision: Accept
On 03 Aug, 2020
No comments provided
Editor assigned
On 27 Jul, 2020
Submission checks complete
On 26 Jul, 2020
Editor invited
On 26 Jul, 2020
No comments provided
Editorial decision: Minor revision
On 17 Jul, 2020
Editor assigned
On 15 Jul, 2020
Submission checks complete
On 14 Jul, 2020
Editor invited
On 14 Jul, 2020
No comments provided
Editorial decision: Minor revision
On 29 Jun, 2020
Editor assigned
On 29 May, 2020
Submission checks complete
On 28 May, 2020
Editor invited
On 28 May, 2020
No comments provided
Review #3 received
Received 14 May, 2020
Editorial decision: Minor revision
On 14 May, 2020
Review #2 received
Received 10 May, 2020
Reviewer #3 agreed
On 21 Apr, 2020
Reviewer #2 agreed
On 20 Apr, 2020
Reviewer #1 agreed
On 18 Apr, 2020
Review #1 received
Received 18 Apr, 2020
Reviewers invited
Invitations sent on 17 Apr, 2020
Editor assigned
On 13 Apr, 2020
Submission checks complete
On 12 Apr, 2020
Editor invited
On 12 Apr, 2020
Version 1
Posted 23 Jan, 2020
No comments provided
Editorial decision: Major revision
On 04 Mar, 2020
Review #3 received
Received 27 Feb, 2020
Review #2 received
Received 13 Feb, 2020
Reviewer #3 agreed
On 13 Feb, 2020
Review #1 received
Received 13 Feb, 2020
Reviewer #2 agreed
On 12 Feb, 2020
Reviewers invited
Invitations sent on 02 Feb, 2020
Reviewer #1 agreed
On 02 Feb, 2020
Editor assigned
On 22 Jan, 2020
Submission checks complete
On 21 Jan, 2020
Editor invited
On 20 Jan, 2020
First submitted
On 16 Jan, 2020
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A new preprint design is coming!
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See the published version of this preprint at BMC Medical Genetics.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
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Prescreen
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Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Medical Genetics.
No community comments so far
Submission checks complete
On 04 Aug, 2020
Editorial decision: Accept
On 03 Aug, 2020
No comments provided
Editor assigned
On 27 Jul, 2020
Submission checks complete
On 26 Jul, 2020
Editor invited
On 26 Jul, 2020
No comments provided
Editorial decision: Minor revision
On 17 Jul, 2020
Editor assigned
On 15 Jul, 2020
Submission checks complete
On 14 Jul, 2020
Editor invited
On 14 Jul, 2020
No comments provided
Editorial decision: Minor revision
On 29 Jun, 2020
Editor assigned
On 29 May, 2020
Submission checks complete
On 28 May, 2020
Editor invited
On 28 May, 2020
No comments provided
Review #3 received
Received 14 May, 2020
Editorial decision: Minor revision
On 14 May, 2020
Review #2 received
Received 10 May, 2020
Reviewer #3 agreed
On 21 Apr, 2020
Reviewer #2 agreed
On 20 Apr, 2020
Reviewer #1 agreed
On 18 Apr, 2020
Review #1 received
Received 18 Apr, 2020
Reviewers invited
Invitations sent on 17 Apr, 2020
Editor assigned
On 13 Apr, 2020
Submission checks complete
On 12 Apr, 2020
Editor invited
On 12 Apr, 2020
Version 1
Posted 23 Jan, 2020
No comments provided
Editorial decision: Major revision
On 04 Mar, 2020
Review #3 received
Received 27 Feb, 2020
Review #2 received
Received 13 Feb, 2020
Reviewer #3 agreed
On 13 Feb, 2020
Review #1 received
Received 13 Feb, 2020
Reviewer #2 agreed
On 12 Feb, 2020
Reviewers invited
Invitations sent on 02 Feb, 2020
Reviewer #1 agreed
On 02 Feb, 2020
Editor assigned
On 22 Jan, 2020
Submission checks complete
On 21 Jan, 2020
Editor invited
On 20 Jan, 2020
First submitted
On 16 Jan, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Medical Genetics.
Background Diabetes is mostly assessed by the fasting glucose level. Several studies reported that serum fasting glucose levels are causally associated with MC4R.
Methods A total of 4,294 subjects participated in this study. We used multivariate linear regression models and multiple logistic regression analysis.
Results Individuals with the TC/CC genotype had a 1.29-fold higher risk of diabetes than did those with the TT genotype when adjusting for age, sex, and BMI (OR, 1.29; 95% CI, 1.04-1.60). For healthy subjects, the association was significant in females (OR, 1.99; 95% CI, 1.01-3.93). Male participants with the TC/CC genotype had a 1.21-fold higher risk of cardiovascular disease than did those with the TT genotype when adjusting for age, sex, and BMI (OR, 1.21; 95% CI, 1.04-1.41). The relationship between MC4R and cardiovascular disease was stronger in lean male individuals (OR, 1.40; 95% CI, 1.12–1.74, p = 0.0028) than in obese male subjects.
Conclusions This study suggests that the rs17782313 SNP in MC4R is related to diabetes and the SNP is also associated with cardiovascular disease in lean male individuals.
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