This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Jun Gao
Wuhan Childrens Hospital: Wuhan Women and Children Medical Care Center
Corresponding Author
ORCiD: https://orcid.org/0000-0001-5746-9334
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background Real-time three-dimensional volume echocardiography could obtain ventricular volume and ejection fraction rapidly and non-invasively without relying on ventricular morphology. Infants under one year of age with medium to large ventricular septal defect（VSD） and pulmonary hypertension have the characteristics of recurrent pulmonary infection and feeding difficulties. For these children, early surgery is recommended to reduce pulmonary congestion. Evaluation of biventricular volume and pumping function is important to determine the time of surgery.
Methods In this study 18 children with medium to large VSD complicated with pulmonary hypertension (VSD/PH group ) and 18 healthy children of the same age (control group) were recruited. Biventricular diameter, volume and systolic function were evaluated by two-dimensional echocardiography (2DE), M-mode, tissue Doppler and real-time three-dimensional echocardiography (RT-3DE). The measurements included: left and right ventricular diameter, body surface area standardized ventricular volume (LVEDV/BSA, RVEDV/BSA), LVEF ( M-mode), TAPSE (tricuspid annulus displacement), TAV (tricuspid annulus velocity), LVEF (RT-3DE), RVEF (RT-3DE).
Results Both left and right ventricular diameter and LVEDV/BSA, RVEDV/BSA were significantly larger than those in normal controls (P <0.05). Compared with normal group, LVEF (RT-3DE), RVEF (RT-3DE) and TAV in VSD/PH group decreased (P <0.05). However there were no significant difference in LVEF (M-mode) and TAPSE between the two groups (P >0.05).
Conclusion RT-3DE provides a new approach for noninvasive and rapid assessment of cardiac volume and systolic function for infants with ventricular septal defect and pulmonary hypertension.
Keywords
real-time three-dimensional echocardiography, ventricular septal defect, pulmonary hypertension, infant
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Jun Gao
Wuhan Childrens Hospital: Wuhan Women and Children Medical Care Center
Corresponding Author
ORCiD: https://orcid.org/0000-0001-5746-9334
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 10 Dec, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cardiac & Cardiovascular Systems
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background Real-time three-dimensional volume echocardiography could obtain ventricular volume and ejection fraction rapidly and non-invasively without relying on ventricular morphology. Infants under one year of age with medium to large ventricular septal defect（VSD） and pulmonary hypertension have the characteristics of recurrent pulmonary infection and feeding difficulties. For these children, early surgery is recommended to reduce pulmonary congestion. Evaluation of biventricular volume and pumping function is important to determine the time of surgery.
Methods In this study 18 children with medium to large VSD complicated with pulmonary hypertension (VSD/PH group ) and 18 healthy children of the same age (control group) were recruited. Biventricular diameter, volume and systolic function were evaluated by two-dimensional echocardiography (2DE), M-mode, tissue Doppler and real-time three-dimensional echocardiography (RT-3DE). The measurements included: left and right ventricular diameter, body surface area standardized ventricular volume (LVEDV/BSA, RVEDV/BSA), LVEF ( M-mode), TAPSE (tricuspid annulus displacement), TAV (tricuspid annulus velocity), LVEF (RT-3DE), RVEF (RT-3DE).
Results Both left and right ventricular diameter and LVEDV/BSA, RVEDV/BSA were significantly larger than those in normal controls (P <0.05). Compared with normal group, LVEF (RT-3DE), RVEF (RT-3DE) and TAV in VSD/PH group decreased (P <0.05). However there were no significant difference in LVEF (M-mode) and TAPSE between the two groups (P >0.05).
Conclusion RT-3DE provides a new approach for noninvasive and rapid assessment of cardiac volume and systolic function for infants with ventricular septal defect and pulmonary hypertension.
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