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Research Article
Javier Cruz
Uppsala University
Corresponding Author
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Microfluidics exploiting the phenomenon of inertial focusing have attracted much attention in the last decade, as they provide the means to facilitate the detection and analysis of rare particles of interest in complex fluids such as blood and natural water. Although many interesting applications have been demonstrated, the systems remain difficult to engineer. A recently presented line of the technology, inertial focusing in High Aspect Ration Curved (HARC) microfluidics, has the potential to change this and make the benefits of inertial focusing more accessible to the community. In this paper, with experimental evidence and fluid simulations, we provide the two necessary equations to design the systems and successfully focus the desired targets in a single, stable, and high-quality position. Last, the experiments revealed an interesting scaling law of the lift force, which we believe provides a valuable insight into the phenomenon of inertial microfluidics.
Keywords
Microfluidics, High Aspect Ration Curved (HARC), high-quality position, inertial microfluidics
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View the published article at Scientific Reports.
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Posted 11 Dec, 2020
No community comments so far
Editorial decision: Major revision
On 01 Feb, 2021
Reviews received
Received 29 Dec, 2020
Reviewers agreed
On 15 Dec, 2020
Reviewers agreed
On 09 Dec, 2020
Reviewers invited
Invitations sent on 09 Dec, 2020
Editor assigned
On 09 Dec, 2020
Editor invited
On 09 Dec, 2020
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On 09 Dec, 2020
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On 07 Dec, 2020
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Systems Biology
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A new preprint design is coming!
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See the published version of this preprint at Scientific Reports.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Javier Cruz
Uppsala University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Scientific Reports.
Version 1
Posted 11 Dec, 2020
No community comments so far
Editorial decision: Major revision
On 01 Feb, 2021
Reviews received
Received 29 Dec, 2020
Reviewers agreed
On 15 Dec, 2020
Reviewers agreed
On 09 Dec, 2020
Reviewers invited
Invitations sent on 09 Dec, 2020
Editor assigned
On 09 Dec, 2020
Editor invited
On 09 Dec, 2020
Submission checks complete
On 09 Dec, 2020
First submitted
On 07 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Systems Biology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Scientific Reports.
Microfluidics exploiting the phenomenon of inertial focusing have attracted much attention in the last decade, as they provide the means to facilitate the detection and analysis of rare particles of interest in complex fluids such as blood and natural water. Although many interesting applications have been demonstrated, the systems remain difficult to engineer. A recently presented line of the technology, inertial focusing in High Aspect Ration Curved (HARC) microfluidics, has the potential to change this and make the benefits of inertial focusing more accessible to the community. In this paper, with experimental evidence and fluid simulations, we provide the two necessary equations to design the systems and successfully focus the desired targets in a single, stable, and high-quality position. Last, the experiments revealed an interesting scaling law of the lift force, which we believe provides a valuable insight into the phenomenon of inertial microfluidics.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
The full text of this article is available to read as a PDF.
This is a list of supplementary files associated with this preprint. Click to download.
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