There is a regular array of atoms or ions in the crystal. X-ray diffraction method uses a certain wavelength of X-ray to irradiate on different crystals, and the X-rays scattered by different atoms interfere with each other. The distribution direction and intensity of the X-ray diffraction in the crystal space are different, and the unique map of each mineral will be formed, so as to analyze the composition of the measured sample according to the comparative analysis of the obtained map. The method has the advantages of no damage to the sample, good repeatability, fast and effective, large amount of information and simple analysis. Combined with polarized light microscopy, it can further confirm the existence of asbestos fiber in powder cosmetics and improve the accuracy of detection.[[i]]
The detection rate of chrysotile powders with price less than 10 yuan and those purchased online was higher. This may be because manufacturers of cheap body powder are more likely to choose inferior talc raw materials in order to reduce costs, and do not pay attention to product quality control. In addition, due to the current regulatory system of China ' s online shopping is not perfect, and the supervision is not enough, the unscrupulous merchants are more likely to sell the body powder of poor quality.
CA125 in this study is a high molecular weight glycoprotein antigen derived from luminal epithelial cells. As an important ovarian cancer-related antigen, CA125 is the main indicator of ovarian cancer screening, diagnosis, disease monitoring, prognosis and efficacy evaluation in clinic.[[ii]] HE4 is a newer tumor marker than CA125, which is highly expressed in the genital tract and epithelial cells of ovarian cancer tissues. It has high sensitivity and specificity in the early diagnosis of ovarian cancer, and can be used as a reliable sensitive indicator of ovarian cancer. [[iii]-9[iv]9999999] Combined detection of serum CA125 and HE4 levels can effectively improve the sensitivity, specificity and accuracy of ovarian cancer detection.[[v]]
At 90 days, CA125 and HE4 in each experimental group were significantly higher than those in the control group, but no obvious pathological changes were found in the ovarian tissue, suggesting that although the ovarian function of rats in the experimental group had changed, the ovarian structure had not been seriously damaged. At 180 days, the ovarian structure also changed significantly. In addition, The structural changes of ovaries in asbestos+talc group were also the most obvious.
It can be seen that either talc or asbestos dust, long-term low concentration exposure will affect ovarian health. Also indicating that if the powder was contaminated by asbestos, and if the user was too close to the genitals and exposed to the mixed dust for a long time, the impact on ovarian health was more serious. In addition, the infant's skin barrier function was incomplete, and the skin was thinner than that of adults, the keratinocytes were small, the body surface area was small, the sweat gland density was higher than that of adults, and the sweating temperature was higher than that of adults. The retention of sweat in the skin wrinkles caused irritation to the skin, and it was more likely to cause skin problems such as redness and prickly heat.[[vi]-[vii][viii]] So many parents used body powder for infants and children, and it was more frequently used in the thigh root, buttock and other parts that were prone to accumulate sweat. Children, especially infants' immune system and other physical functions are not fully developed. If the long time exposure to asbestos pollution near the genital area, the harm is more serious.
Some studies have found that direct exposure to talcum powder in the ovary can increase the expression of Gsr, Sod1 gene and miRNA, which is harmful to ovarian tissue .[[ix]] Hamilton[[x]] and so on injected talcum powder suspension into the ovary of rats, and the ovary formed obvious cysts and papillary changes. In addition, talcum powder can induce changes in key oxidoreductases, and enhance the pro-oxidation state of normal cells and epithelial ovarian cancer cells, and talc exposure can significantly induce cell proliferation of cancer cells .[[xi]] Epidemiological studies and META analysis also show that there is a link between the use of talcum powder in genitalia and serous ovarian cancer.[[xii]-[xiii][xiv]] Many studies have confirmed in different ways that talcum powder has a certain impact on ovary health, but there is still a lack of research on the impact of asbestos on these aspects. In this study, animal experiments were carried out to verify the damage of talcum powder to ovarian health, which supplemented the impact of asbestos on ovarian health and the damage of asbestos pollution to ovarian health.