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Research Article
Hidekazu Moriya
Shonan Kamakura General Hospital
Corresponding Author
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Background: In chronic kidney disease (CKD) patients, vascular calcification occurs in the early stage of CKD, before the titer of existing CKD mineral bone disorder (CKD-MBD)-related markers exceed the threshold. Calciprotein particles (CPPs) are crystals in which excessive phosphorus and calcium in the blood form colloidal particles and are associated with vascular calcification. However, it is unknown whether CPPs are a more sensitive marker for detecting calcification than others. Methods: In a prospective cohort study of 58 patients with CKD we examined CKD-MBD markers, including CPPs. Vascular arterial calcification score (ACS) of the lower extremities was measured with the Agatston score. One year later, the markers and ACS were reevaluated, and the relationship between the degree of progression of vascular calcification and CKD-MBD markers was evaluated. Results: The CPP titer was significantly correlated with that of serum phosphate and corrected calcium. However, the CPP titer showed no correlation with eGFR or ACS in the lower extremities. After one year, the basic titers of serum creatinine, eGFR, FGF-23, intact-PHT, 1.25-dihydroxyvitamin D3 and CPP were not significantly correlated with ACS changes in the lower extremities. There was a significant correlation between the rate of change in ACS and that in CPP (r = 0.292, p = 0.0258). CPP was an independent risk factor for the progression of calcification in the lower extremities in a multivariate analysis (p = 0.0144). Conclusions: CPP is a more sensitive marker of arterial calcification than other CKD-MBD markers in patients with CKD. Key words: Calciprotein particle, Chronic kidney disease, Vascular calcification
Keywords
Calciprotein particle, Chronic kidney disease, Vascular calcification
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CURRENT STATUS: Under Revision
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Posted 15 Dec, 2020
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Received 29 Dec, 2020
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On 22 Dec, 2020
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On 16 Dec, 2020
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Editor invited
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Subject Areas
Urology & Nephrology
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This preprint is under consideration at BMC Nephrology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Hidekazu Moriya
Shonan Kamakura General Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Revision
Version 1
Posted 15 Dec, 2020
No community comments so far
Editorial decision: Major revision
On 17 Jan, 2021
Reviews received
Received 29 Dec, 2020
Reviewers agreed
On 22 Dec, 2020
Reviewers agreed
On 16 Dec, 2020
Reviewers invited
Invitations sent on 14 Dec, 2020
Editor assigned
On 14 Dec, 2020
Editor invited
On 14 Dec, 2020
Submission checks complete
On 14 Dec, 2020
First submitted
On 07 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Urology & Nephrology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: In chronic kidney disease (CKD) patients, vascular calcification occurs in the early stage of CKD, before the titer of existing CKD mineral bone disorder (CKD-MBD)-related markers exceed the threshold. Calciprotein particles (CPPs) are crystals in which excessive phosphorus and calcium in the blood form colloidal particles and are associated with vascular calcification. However, it is unknown whether CPPs are a more sensitive marker for detecting calcification than others. Methods: In a prospective cohort study of 58 patients with CKD we examined CKD-MBD markers, including CPPs. Vascular arterial calcification score (ACS) of the lower extremities was measured with the Agatston score. One year later, the markers and ACS were reevaluated, and the relationship between the degree of progression of vascular calcification and CKD-MBD markers was evaluated. Results: The CPP titer was significantly correlated with that of serum phosphate and corrected calcium. However, the CPP titer showed no correlation with eGFR or ACS in the lower extremities. After one year, the basic titers of serum creatinine, eGFR, FGF-23, intact-PHT, 1.25-dihydroxyvitamin D3 and CPP were not significantly correlated with ACS changes in the lower extremities. There was a significant correlation between the rate of change in ACS and that in CPP (r = 0.292, p = 0.0258). CPP was an independent risk factor for the progression of calcification in the lower extremities in a multivariate analysis (p = 0.0144). Conclusions: CPP is a more sensitive marker of arterial calcification than other CKD-MBD markers in patients with CKD. Key words: Calciprotein particle, Chronic kidney disease, Vascular calcification
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The full text of this article is available to read as a PDF.
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