Based on the 12-year (2007-2018) salinity data from Array for Real-Time Geostrophic Oceanography (ARGO), significantly positive salinity anomalies are found in the upper layer of the tropical central Indian Ocean (IO) from 2010 boreal autumn to 2011 boreal spring and from 2016 boreal autumn to 2017 boreal spring. Wind, precipitation, outgoing longwave radiation (OLR) and ocean currents from satellite and reanalysis data are utilized to analyze the atmospheric, ocean dynamic processes and the salinity budget associated with the high salinity events. The results indicate that surface buoyancy fluxes are not the dominant factor affecting the positive salinity anomalies, while ocean dynamic processes play a more important role. Under the influence of the La Niña and strong negative Indian Ocean Dipole (nIOD) in 2010 and 2016, positive salinity anomalies appear in the eastern IO at the end of 2010 and 2016 due to strong westerlies and positive zonal currents. But because the La Niña in 2010 is stronger than in 2016, the salinity anomalies in 2010 are stronger, and the decline in the following year is stronger and lasts longer, making the salinity anomalies gradually weakened. Therefore, the maximum value of the salinity anomalies in 2011 is in January, while in 2017 the salinity anomalies first decrease and then increase with the largest in March. Salinity budget analyses also show that ocean advection is the main factor leading to the salinity anomaly variations for these two periods. Among them, the changes of the zonal velocity in the zonal advection anomalies have the greatest impact. The zonal advection is positive and the strongest at the end of 2010 and negative in early 2011, but weak positive at the end of 2016. In early 2017 the zonal advection is first negative, then becomes positive and strengthens in spring, so salinity anomalies in 2017 spring is higher than that in 2011. The entrainment effect during 10A11S is more significant than 16A17S and the freshwater flux (FWF) has a small and negative effect on positive salinity anomalies for two events. The mutual effects of horizontal advection, FWF and vertical entrainment together lead to high salinity anomalies. The high salinity anomalies reflect the upper-ocean responses to climate events, which may also influence the regional air-sea interactions and large-scale processes.