Investigators have reported reduced visibility of the cone photoreceptors overlying drusen using adaptive optics (AO) imaging techniques. Two concordant hypotheses have been proposed to explain this phenomenon. Firstly, the disease-related deformation of the photoreceptor outer segment (OS) may reduce its ability to act as a wave guide, thus decreasing the cell’s familiar reflectance pattern. Alternatively, drusen could disorient the photoreceptors away from the eye’s pupil, reducing the amount of light reflected back out the pupil. In this work we use directional OCT (dOCT) images of drusen in AMD patients to measure the respective contributions of the above-mentioned deforming and disorienting factors.