Background and objective: Myocardial infarction is the number one cause of death both in males and females in many developed countries. Citrullus colocynthis is a medicinal plant used for the treatment for asthma, constipation, cough. The current study evaluates the cardioprotective potential of hydroalcoholic peel extract of Citrullus colocynthis against adrenaline-induced myocardial infarction in rabbits.
Materials and Methods: Animals were divided into four major groups each group consisting of six rabbits. Group - 1 was given adrenaline 2mg/kg subcutaneously for two successive days. Considerably (p<0.001) accelerated the ALP, AST, ALT, Troponin, CK-MB, LDH, and CRP (p<0.05). Group 2, 3, 4 rabbits pre-treated with the peel extract of C. colocynthis 100mg/kg, 200mg/kg, 300mg/kg respectively orally for 14 successive days and on 14th and 15th-day adrenaline was inoculated considerably improve the impact of adrenaline through lowering the levels of CK-MB, LDH, Troponin, AST, CRP, ALT, and ALP.
Results: The myocardial tissues of adrenaline induced group have more necrotic lesions. A slight deteriorating modifications of myocardial tissues usually in cardiac cells structure were observed in the group treated with extract.
Conclusion: The out-turn showed the cardioprotective potential of hydroalcoholic peel extract of C. colocynthis in a dose-dependent manner.