This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
Research article
Xin Sun
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: To investigate the incidence of symptomatic knee osteoarthritis (OA) and identify risk factors among the Chinese population.
Methods: The China Health and Retirement Longitudinal Study (CHARLS) is a nationwide longitudinal survey of persons aged ≥45 years. The baseline survey for the CHARLS study was conducted in 2011 using a four-stage, stratified, cluster probability sampling design. The respondents were then followed up every 2 years through a face-to-face interview. Using the national survey data collected from the CHARLS, we estimated the incidence of symptomatic knee OA, taking into account the complex survey design and response rate. We applied weighted logistic regression analysis to identify risk factors.
Results: In the 4 years of follow-up, the cumulative incidence of symptomatic knee OA among middle-aged and older Chinese adults was 8.5%; the incidence was higher among females (11.2%) than males (5.6%). In the longitudinal analysis, female, rural area, West region, low education level, lack of physical activities, and the presence of heart disease, kidney disease, and digestive disease at the baseline survey were associated with a higher risk of symptomatic knee OA. The risk in persons doing regular physical activities was 53% lower than that in persons who were not active (odds ratio (OR) 0.47 95% CI) 0.29–0.76). Histories of heart disease (odds ratio (OR) 1.40 95% confidence interval (CI) 1.07–1.82), kidney disease (OR 1.80 95% CI 1.35–2.39), and digestive disease (OR 1.54 95% CI 1.30–1.82) were associated with a higher risk of symptomatic knee OA.
Conclusion: The cumulative incidence of symptomatic knee OA over 4 years was relatively high, and varied by province and region. Lack of physical activities, and the presence of heart disease, kidney disease, and digestive disease were associated with a higher risk of symptomatic knee OA.
Keywords
symptomatic knee OA, incidence, middle-aged and older, Chinese population, risk factor
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 24 Jan, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Learn more about our company.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Xin Sun
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 24 Jan, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: To investigate the incidence of symptomatic knee osteoarthritis (OA) and identify risk factors among the Chinese population.
Methods: The China Health and Retirement Longitudinal Study (CHARLS) is a nationwide longitudinal survey of persons aged ≥45 years. The baseline survey for the CHARLS study was conducted in 2011 using a four-stage, stratified, cluster probability sampling design. The respondents were then followed up every 2 years through a face-to-face interview. Using the national survey data collected from the CHARLS, we estimated the incidence of symptomatic knee OA, taking into account the complex survey design and response rate. We applied weighted logistic regression analysis to identify risk factors.
Results: In the 4 years of follow-up, the cumulative incidence of symptomatic knee OA among middle-aged and older Chinese adults was 8.5%; the incidence was higher among females (11.2%) than males (5.6%). In the longitudinal analysis, female, rural area, West region, low education level, lack of physical activities, and the presence of heart disease, kidney disease, and digestive disease at the baseline survey were associated with a higher risk of symptomatic knee OA. The risk in persons doing regular physical activities was 53% lower than that in persons who were not active (odds ratio (OR) 0.47 95% CI) 0.29–0.76). Histories of heart disease (odds ratio (OR) 1.40 95% confidence interval (CI) 1.07–1.82), kidney disease (OR 1.80 95% CI 1.35–2.39), and digestive disease (OR 1.54 95% CI 1.30–1.82) were associated with a higher risk of symptomatic knee OA.
Conclusion: The cumulative incidence of symptomatic knee OA over 4 years was relatively high, and varied by province and region. Lack of physical activities, and the presence of heart disease, kidney disease, and digestive disease were associated with a higher risk of symptomatic knee OA.
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
Loading...