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Research Article
Patcharee Pripdeevech
Mae Fah Luang University
Corresponding Author
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The essential oil of Peucedanum dhana A. Ham growing in Thailand was investigated for their volatile compounds and screened for its antimicrobial, antioxidant, and cytotoxic activities. Forty-two compounds were identified, with the most important compounds being trans-piperitol, o-cymene, β-pinene, γ-terpinene, and limonene. Essential oil of P. dhana has remarkable antimicrobial activity against tested pathogens with minimum inhibitory concentration and minimum microbicidal concentration values, ranging from 62.50–250 µg/mL and 250-1,000 µg/mL, respectively. The antioxidant activity of P. dhana oil was measured using DPPH and ABTS scavenging activity assays. The IC50 values using the DPPH and ABTS method were 9.13 and 9.36 mg/mL, respectively. The total phenolic compounds in P. dhana oil was 183.05 mg GAE/100 g dry weight. The cytotoxic effect of P. dhana oil was tested against Hela, A549, SW480, and 3T3L1 cells. The essential oil had cytotoxicity against all cancer cells, with significant cytotoxicity towards the SW480 cell. The results indicate that the P. dhana essential oil could be used as a source of functional ingredients in food and pharmaceutical applications.
Keywords
antimicrobial, antioxidant, cytotoxic , o-cymene, β-pinene, γ-terpinene
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CURRENT STATUS: Under Review
Version 1
Posted 11 Dec, 2020
No community comments so far
Editorial decision: Major revision
On 01 Feb, 2021
Reviews received
Received 10 Jan, 2021
Reviewers agreed
On 05 Jan, 2021
Reviews received
Received 04 Jan, 2021
Reviewers agreed
On 03 Jan, 2021
Reviewers invited
Invitations sent on 16 Dec, 2020
Editor assigned
On 09 Dec, 2020
Editor invited
On 09 Dec, 2020
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On 09 Dec, 2020
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A new preprint design is coming!
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This preprint is under consideration at Scientific Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Patcharee Pripdeevech
Mae Fah Luang University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 11 Dec, 2020
No community comments so far
Editorial decision: Major revision
On 01 Feb, 2021
Reviews received
Received 10 Jan, 2021
Reviewers agreed
On 05 Jan, 2021
Reviews received
Received 04 Jan, 2021
Reviewers agreed
On 03 Jan, 2021
Reviewers invited
Invitations sent on 16 Dec, 2020
Editor assigned
On 09 Dec, 2020
Editor invited
On 09 Dec, 2020
Submission checks complete
On 09 Dec, 2020
First submitted
On 09 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The essential oil of Peucedanum dhana A. Ham growing in Thailand was investigated for their volatile compounds and screened for its antimicrobial, antioxidant, and cytotoxic activities. Forty-two compounds were identified, with the most important compounds being trans-piperitol, o-cymene, β-pinene, γ-terpinene, and limonene. Essential oil of P. dhana has remarkable antimicrobial activity against tested pathogens with minimum inhibitory concentration and minimum microbicidal concentration values, ranging from 62.50–250 µg/mL and 250-1,000 µg/mL, respectively. The antioxidant activity of P. dhana oil was measured using DPPH and ABTS scavenging activity assays. The IC50 values using the DPPH and ABTS method were 9.13 and 9.36 mg/mL, respectively. The total phenolic compounds in P. dhana oil was 183.05 mg GAE/100 g dry weight. The cytotoxic effect of P. dhana oil was tested against Hela, A549, SW480, and 3T3L1 cells. The essential oil had cytotoxicity against all cancer cells, with significant cytotoxicity towards the SW480 cell. The results indicate that the P. dhana essential oil could be used as a source of functional ingredients in food and pharmaceutical applications.
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