The purpose of research was to understand the effect of manila palm (Adonidia merrillii Becc.) supplementation on production performance, rumen fermentation, hematology and eradication of gastro-intestinal nematodes of goat. Sixteen native crossbred goats the ages of 1-2 year are divided into 8 males and 8 females at initial body weight (BW) of 20±3.1 kg was used in this experiment. The experiment was a randomized complete block design (RCBD) trial was planned to compare 4 supplementation forms of ivermectin and manila palm. Group 1 received ivermectin 3.03 microgram /kg body weight. Groups 2, 3 and 4 were treated with seeds in manila palm, manila palm peel and manila palm whole extract 5 ml / goat weight 1 kg, respectively. Results revealed that average daily gain, feed conversion ratio, feed intake, digestibility, BUN, Hct, ruminal pH, NH3 -N, temperature, total VFA and butyric acid were non significantly (P>0.05). The concentration of acetic acid was decreased by supplementation of manila palm (P<0.05) whereas propionic acid was increased (P<0.05) by goat fed manila palm especially manila palm whole extract 5 ml / goat weight 1 kg when compare with author group. However, CH4 was decreased (P<0.05) as result of supplementation of manila palm compared to author group. Whereas, goats fed manila palm whole extract decreased the protozoal population (P<0.05). After the goat receives treatment at 1, 3, 14 days showed a decrease in the goat’s fecal egg count was no significant (P>0.05). After receives treatment at 7 and 21 days showed a decrease in the goat’s fecal egg count had significant (P < 0.05). After that at 28 and 35 days the results showed increase in the goat’s fecal egg count had significant (P < 0.05). This study concluded that supplementation of manila palm whole extract 5 ml / goat weight 1 kg resulted in increased propionic acid and decreased CH4 production, protozoa population and fecal eggs counts. This study concluded that feeding of manila palm whole extract 5 ml / goat weight 1 kg is recommended because it has the best level for use as animal feed supplementation.