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Research article
Parisa Ghasemiyeh
Shiraz University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8640-5724
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
One of the most common causes of death in the world is coronary artery disease (CAD). Estrogen, the most important early sex hormones in women, plays an important role in the risk reduction of cardiovascular disease (CVD). Expression of estrogen as well as its receptorsˈ including estrogen receptor alpha (ER1) and estrogen receptor beta (ER2) might have an association with the severity or complexity of CAD. Since most articles have focused on the relationship between ER1 gene polymorphism and CAD, in this study we aimed to evaluate the association of two ER2 gene polymorphisms, AluI and RsaI, with severity of CAD.
Methods
148 patients with confirmed CAD who underwent elective percutaneous coronary intervention (PCI) were included in this study. Blood samples were collected before coronary angiography and ER2 gene polymorphisms were analyzed by the PCR-RFLP method. The STNTAX Score (SS), grading system for CAD complexity, was evaluated by an interventional cardiologist who was blinded to other data.
Results
110 men and 38 women were participated in this study. Our results revealed a statistically significant relationship between SS and RsaI polymorphism of ER2 (p = 0.01). In contrast, there was no association between AluI genotypes and SS.
Conclusions
Besides to estrogen level, the genetic variation of its receptors might play an important role in the severity or complexity of CAD. According to our results, RsaI polymorphism of ER2 gene may assert a pivotal role in the severity of CAD; however this assumption needs to be proved in studies with a larger population.
Keywords
Cardiovascular disease, Estrogen receptor Beta, Polymorphism, SYNTAX Score
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Parisa Ghasemiyeh
Shiraz University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8640-5724
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 15 Dec, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
One of the most common causes of death in the world is coronary artery disease (CAD). Estrogen, the most important early sex hormones in women, plays an important role in the risk reduction of cardiovascular disease (CVD). Expression of estrogen as well as its receptorsˈ including estrogen receptor alpha (ER1) and estrogen receptor beta (ER2) might have an association with the severity or complexity of CAD. Since most articles have focused on the relationship between ER1 gene polymorphism and CAD, in this study we aimed to evaluate the association of two ER2 gene polymorphisms, AluI and RsaI, with severity of CAD.
Methods
148 patients with confirmed CAD who underwent elective percutaneous coronary intervention (PCI) were included in this study. Blood samples were collected before coronary angiography and ER2 gene polymorphisms were analyzed by the PCR-RFLP method. The STNTAX Score (SS), grading system for CAD complexity, was evaluated by an interventional cardiologist who was blinded to other data.
Results
110 men and 38 women were participated in this study. Our results revealed a statistically significant relationship between SS and RsaI polymorphism of ER2 (p = 0.01). In contrast, there was no association between AluI genotypes and SS.
Conclusions
Besides to estrogen level, the genetic variation of its receptors might play an important role in the severity or complexity of CAD. According to our results, RsaI polymorphism of ER2 gene may assert a pivotal role in the severity of CAD; however this assumption needs to be proved in studies with a larger population.
Figure 1
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