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Research Article
Alberto Jiménez-Maldonado
Facultad de Deportes Campus Ensenada, Universidad Autónoma de Baja California
Corresponding Author
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The aim of the current meta-analysis was to determine the effects of acute and chronic interval training (IT) on peripheral BDNF concentrations in healthy young adults. A literature search was performed using six databases until February 2020. The TESTEX scale was used to assess the quality of studies. Effect sizes (ES) were computed and two-tailed α values <0 .05 and non-overlapping 95% confidence intervals (95% CI) were considered statistically significant. Heterogeneity, inconsistency (I2), and small-study effects using the Luis Furuya-Kanamori (LFK) index were examined. Fifteen studies (n=277 participants, age =24±3 yr.) were included. The overall effects of IT on circulating BDNF concentrations were moderate and non-significant (ES =0.64, 95%CI = -0.01, 1.30, heterogeneous (p<0.001), highly inconsistent (I2=90%), and with major asymmetry (LFK index =2.85). The acute effect of IT on peripheral BDNF levels was large and significant (ES =1.22, 95%CI =0.08), homogenous (p<0.001), with considerable inconsistency (I2=93%), and major asymmetry (LFK index =3.34). The chronic effect of IT on circulating BDNF was large and significant (ES =0.93, 95%CI =0.40), homogenous (p<0.001), with moderate inconsistency (I2=70%), and minor asymmetry (LFK index =1.21). Acute and chronic IT, elicited a moderate increase in peripheral BDNF concentrations in a healthy young population.
Keywords
BDNF, interval training, LFK
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View the published article at Scientific Reports.
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Editorial decision: Major revision
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See the published version of this preprint at Scientific Reports.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Alberto Jiménez-Maldonado
Facultad de Deportes Campus Ensenada, Universidad Autónoma de Baja California
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Scientific Reports.
Version 1
Posted 17 Dec, 2020
No community comments so far
Editorial decision: Major revision
On 19 Jan, 2021
Reviews received
Received 02 Jan, 2021
Reviewers agreed
On 22 Dec, 2020
Reviewers invited
Invitations sent on 21 Dec, 2020
Editor assigned
On 21 Dec, 2020
Editor invited
On 15 Dec, 2020
Submission checks complete
On 15 Dec, 2020
First submitted
On 09 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Scientific Reports.
The aim of the current meta-analysis was to determine the effects of acute and chronic interval training (IT) on peripheral BDNF concentrations in healthy young adults. A literature search was performed using six databases until February 2020. The TESTEX scale was used to assess the quality of studies. Effect sizes (ES) were computed and two-tailed α values <0 .05 and non-overlapping 95% confidence intervals (95% CI) were considered statistically significant. Heterogeneity, inconsistency (I2), and small-study effects using the Luis Furuya-Kanamori (LFK) index were examined. Fifteen studies (n=277 participants, age =24±3 yr.) were included. The overall effects of IT on circulating BDNF concentrations were moderate and non-significant (ES =0.64, 95%CI = -0.01, 1.30, heterogeneous (p<0.001), highly inconsistent (I2=90%), and with major asymmetry (LFK index =2.85). The acute effect of IT on peripheral BDNF levels was large and significant (ES =1.22, 95%CI =0.08), homogenous (p<0.001), with considerable inconsistency (I2=93%), and major asymmetry (LFK index =3.34). The chronic effect of IT on circulating BDNF was large and significant (ES =0.93, 95%CI =0.40), homogenous (p<0.001), with moderate inconsistency (I2=70%), and minor asymmetry (LFK index =1.21). Acute and chronic IT, elicited a moderate increase in peripheral BDNF concentrations in a healthy young population.
Figure 1
Figure 2
Figure 2
Figure 3
Figure 3
Figure 3
Figure 4
This is a list of supplementary files associated with this preprint. Click to download.
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