Expression of Epithelial-Mesenchymal Transition Related Markers in Plasmacytoid Urothelial Carcinoma of the Urinary Bladder
Background: Plasmacytoid urothelial carcinoma (PUC) of the urinary bladder is a variant of urothelial carcinoma that carries a poor prognosis. The epithelial-mesenchymal transition (EMT) has been demonstrated to contribute to tumor progression. As the cause of the increased aggressiveness of PUC is unknown, we investigated PUC and EMT-related marker expression.
Methods: A total of 633 bladder carcinoma cases diagnosed from 2006 to 2015 at the Nippon Medical School Hospital were analyzed. Twelve patients were found to have plasmacytoid histology and diagnosed with PUC. Slides were evaluated for percentage of plasmacytoid variant, and stained for E-cadherin, N-cadherin, Vimentin, Fibronectin and Snail expression.
Results: The incidence of PUC was 1.9% (12/633). The median patient age at diagnosis was 71 years (range, 60–80 years) and the male-female ratio was 11:1. All but three patients had stage T2b or higher. The median overall survival was 10 months. In 10/12 cases, Snail and N-cadherin were positive. Vimentin was positive in 9/12 cases. Fibronectin was positive in 8/12 cases. While E-cadherin was negative in 10/12 cases. Nine cases showed >10% plasmacytoid component. Eight of the nine patients (88.9%) with >10% plasmacytoid component died.
Conclusions: The results indicate that PUC may induce EMT and may be associated with high invasion.
Figure 1
Posted 15 Jun, 2020
On 09 Jun, 2020
Received 02 Jun, 2020
Received 24 May, 2020
On 16 May, 2020
Invitations sent on 13 May, 2020
On 13 May, 2020
On 23 Apr, 2020
On 22 Apr, 2020
On 22 Apr, 2020
On 01 Apr, 2020
Received 23 Mar, 2020
On 16 Mar, 2020
Received 22 Feb, 2020
Received 22 Feb, 2020
On 07 Feb, 2020
On 03 Feb, 2020
On 01 Feb, 2020
Invitations sent on 01 Feb, 2020
On 24 Jan, 2020
On 24 Jan, 2020
On 22 Jan, 2020
Expression of Epithelial-Mesenchymal Transition Related Markers in Plasmacytoid Urothelial Carcinoma of the Urinary Bladder
Posted 15 Jun, 2020
On 09 Jun, 2020
Received 02 Jun, 2020
Received 24 May, 2020
On 16 May, 2020
Invitations sent on 13 May, 2020
On 13 May, 2020
On 23 Apr, 2020
On 22 Apr, 2020
On 22 Apr, 2020
On 01 Apr, 2020
Received 23 Mar, 2020
On 16 Mar, 2020
Received 22 Feb, 2020
Received 22 Feb, 2020
On 07 Feb, 2020
On 03 Feb, 2020
On 01 Feb, 2020
Invitations sent on 01 Feb, 2020
On 24 Jan, 2020
On 24 Jan, 2020
On 22 Jan, 2020
Background: Plasmacytoid urothelial carcinoma (PUC) of the urinary bladder is a variant of urothelial carcinoma that carries a poor prognosis. The epithelial-mesenchymal transition (EMT) has been demonstrated to contribute to tumor progression. As the cause of the increased aggressiveness of PUC is unknown, we investigated PUC and EMT-related marker expression.
Methods: A total of 633 bladder carcinoma cases diagnosed from 2006 to 2015 at the Nippon Medical School Hospital were analyzed. Twelve patients were found to have plasmacytoid histology and diagnosed with PUC. Slides were evaluated for percentage of plasmacytoid variant, and stained for E-cadherin, N-cadherin, Vimentin, Fibronectin and Snail expression.
Results: The incidence of PUC was 1.9% (12/633). The median patient age at diagnosis was 71 years (range, 60–80 years) and the male-female ratio was 11:1. All but three patients had stage T2b or higher. The median overall survival was 10 months. In 10/12 cases, Snail and N-cadherin were positive. Vimentin was positive in 9/12 cases. Fibronectin was positive in 8/12 cases. While E-cadherin was negative in 10/12 cases. Nine cases showed >10% plasmacytoid component. Eight of the nine patients (88.9%) with >10% plasmacytoid component died.
Conclusions: The results indicate that PUC may induce EMT and may be associated with high invasion.
Figure 1