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Background-Aim We aimed to compare of fibrinogen, high sensitivie C reactive protein (hsCRP), asymmetric dymethylarginine (ADMA) and nitric oxide (NO) levels as laboratory parameters of vasoreactivity in patients with PCOS. Material and Methods Thirty patients with PCOS and 30 women with normal ovulating cycles were enrolled. Serum levels of NO, ADMA, fibrinogen, FSH, LH and hsCRP were assessed and compared with the control group. Results The mean ADMA, fibrinogen and hsCRP levels were significantly higher, and NO concentrations were lower in the patient group. A significant positive correlation was observed between ADMA and NO levels, ADMA and fibrinogen (r=0.838, p<0.001), and ADMA and hsCRP concentrations. Fibrinogen and NO, and NO and hsCRP levels were significantly negatively correlated in the patient group. In the control group, there was a positive correlation between fibrinogen and age, and there was a negative correlation between NO and FSH. Conclusion The present study determined positive relation between ADMA levels and vasoreactive parameters of patients with PCOS. Women with PCOS have elevated levels of ADMA, fibrinogen and decreased NO that make them candidates for cardiovascular disease. Further studies are required to establish the association of ADMA with vascular reactivity.
Keywords
Polycystic ovary syndrome, asymmetric dimethylarginine, high sensitivie C-reactive protein, vasoreactivity.
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
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History
CURRENT STATUS: Posted
Version 1
Posted 28 Jan, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Sexual & Reproductive Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background-Aim We aimed to compare of fibrinogen, high sensitivie C reactive protein (hsCRP), asymmetric dymethylarginine (ADMA) and nitric oxide (NO) levels as laboratory parameters of vasoreactivity in patients with PCOS. Material and Methods Thirty patients with PCOS and 30 women with normal ovulating cycles were enrolled. Serum levels of NO, ADMA, fibrinogen, FSH, LH and hsCRP were assessed and compared with the control group. Results The mean ADMA, fibrinogen and hsCRP levels were significantly higher, and NO concentrations were lower in the patient group. A significant positive correlation was observed between ADMA and NO levels, ADMA and fibrinogen (r=0.838, p<0.001), and ADMA and hsCRP concentrations. Fibrinogen and NO, and NO and hsCRP levels were significantly negatively correlated in the patient group. In the control group, there was a positive correlation between fibrinogen and age, and there was a negative correlation between NO and FSH. Conclusion The present study determined positive relation between ADMA levels and vasoreactive parameters of patients with PCOS. Women with PCOS have elevated levels of ADMA, fibrinogen and decreased NO that make them candidates for cardiovascular disease. Further studies are required to establish the association of ADMA with vascular reactivity.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
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