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Research Article
Effect of Therapeutic Interventions on Salivary Alpha Amylase and Lipid Profile in Major Depressive Disorder Patients
Arindam Sur
College of Medicine & Sagore Dutta Hospital,Kamarhati
Corresponding Author
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Background
Major depression, a disease status as well as a psychosocial burden. High Salivary alpha amylase (sAA) level and dyslipidaemia have been observed in few occasions of Major Depressive Disorder (MDD) patients.
Results
Drug naïve newly diagnosed MDD patients, with gradual improvement of their depressive status [assessed by HDR-S (p < 0.001) and CGI-S(p < 0.001) at 6 and 12 weeks both] by therapeutic interventions showed significant decrease in sAA level (p < 0.001) and increasing and decreasing trend in HDL-C (p < 0.001) and LDL-C (p = 0.004) level respectively. Single significant negative correlation found between HDL-C level and sAA level (r = − 0.291, p = 0.04) after 3 months of treatment.
Conclusion
sAA and serum lipid profile can be used as biochemical indicators in Major Depressive Disorder patients.
Keywords
sAA, Major depression, dyslipidaemia, MDD patients
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This is a preprint. It has not completed peer review.
Research Article
Effect of Therapeutic Interventions on Salivary Alpha Amylase and Lipid Profile in Major Depressive Disorder Patients
Arindam Sur
College of Medicine & Sagore Dutta Hospital,Kamarhati
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 17 Dec, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Psychiatry
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Major depression, a disease status as well as a psychosocial burden. High Salivary alpha amylase (sAA) level and dyslipidaemia have been observed in few occasions of Major Depressive Disorder (MDD) patients.
Results
Drug naïve newly diagnosed MDD patients, with gradual improvement of their depressive status [assessed by HDR-S (p < 0.001) and CGI-S(p < 0.001) at 6 and 12 weeks both] by therapeutic interventions showed significant decrease in sAA level (p < 0.001) and increasing and decreasing trend in HDL-C (p < 0.001) and LDL-C (p = 0.004) level respectively. Single significant negative correlation found between HDL-C level and sAA level (r = − 0.291, p = 0.04) after 3 months of treatment.
Conclusion
sAA and serum lipid profile can be used as biochemical indicators in Major Depressive Disorder patients.
Figure 1
Figure 1
Figure 1
Figure 1