Effect of Therapeutic Interventions on Salivary Alpha Amylase and Lipid Profile in Major Depressive Disorder Patients
Major depression, a disease status as well as a psychosocial burden. High Salivary alpha amylase (sAA) level and dyslipidaemia have been observed in few occasions of Major Depressive Disorder (MDD) patients.
Drug naïve newly diagnosed MDD patients, with gradual improvement of their depressive status [assessed by HDR-S (p < 0.001) and CGI-S(p < 0.001) at 6 and 12 weeks both] by therapeutic interventions showed significant decrease in sAA level (p < 0.001) and increasing and decreasing trend in HDL-C (p < 0.001) and LDL-C (p = 0.004) level respectively. Single significant negative correlation found between HDL-C level and sAA level (r = − 0.291, p = 0.04) after 3 months of treatment.
sAA and serum lipid profile can be used as biochemical indicators in Major Depressive Disorder patients.
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Posted 17 Dec, 2020
Effect of Therapeutic Interventions on Salivary Alpha Amylase and Lipid Profile in Major Depressive Disorder Patients
Posted 17 Dec, 2020
Major depression, a disease status as well as a psychosocial burden. High Salivary alpha amylase (sAA) level and dyslipidaemia have been observed in few occasions of Major Depressive Disorder (MDD) patients.
Drug naïve newly diagnosed MDD patients, with gradual improvement of their depressive status [assessed by HDR-S (p < 0.001) and CGI-S(p < 0.001) at 6 and 12 weeks both] by therapeutic interventions showed significant decrease in sAA level (p < 0.001) and increasing and decreasing trend in HDL-C (p < 0.001) and LDL-C (p = 0.004) level respectively. Single significant negative correlation found between HDL-C level and sAA level (r = − 0.291, p = 0.04) after 3 months of treatment.
sAA and serum lipid profile can be used as biochemical indicators in Major Depressive Disorder patients.
Figure 1
Figure 1
Figure 1
Figure 1