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Article
Ji Xia
Washington University in St. Louis
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1349-9114
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Visual cortical responses are known to be highly variable across trials within an experimental session. However, the long-term stability of visual cortical responses is poorly understood. Chronic imaging experiments in V1 showed that neural responses to repeated natural movie clips were unstable across weeks. Single neuronal responses consisted of sparse episodic activity which were stable in time but unstable in spike rates across weeks. Further, we found that the individual episode, instead of neuron, served as the basic unit of the week-to-week fluctuation. To investigate how population activity encodes the stimulus, we extracted a stable one-dimensional representation of the time in the natural movie, using an unsupervised method. Moreover, most week-to-week fluctuation was perpendicular to the stimulus encoding direction, thus leaving the stimulus representation largely unaffected. We propose that precise episodic activity with coordinated gain changes are keys to maintain a stable stimulus representation in V1.
Keywords
visual cortical responses, neuronal responses
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The full text of this article is available to read as a PDF.
There is NO Competing Interest.
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A new preprint design is coming!
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See the published version of this preprint at Nature Communications.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Article
Ji Xia
Washington University in St. Louis
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1349-9114
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Nature Communications.
Version 1
Posted 07 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cellular & Molecular Neuroscience
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Nature Communications.
Visual cortical responses are known to be highly variable across trials within an experimental session. However, the long-term stability of visual cortical responses is poorly understood. Chronic imaging experiments in V1 showed that neural responses to repeated natural movie clips were unstable across weeks. Single neuronal responses consisted of sparse episodic activity which were stable in time but unstable in spike rates across weeks. Further, we found that the individual episode, instead of neuron, served as the basic unit of the week-to-week fluctuation. To investigate how population activity encodes the stimulus, we extracted a stable one-dimensional representation of the time in the natural movie, using an unsupervised method. Moreover, most week-to-week fluctuation was perpendicular to the stimulus encoding direction, thus leaving the stimulus representation largely unaffected. We propose that precise episodic activity with coordinated gain changes are keys to maintain a stable stimulus representation in V1.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
The full text of this article is available to read as a PDF.
There is NO Competing Interest.
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