This preprint is under consideration at Journal of Animal Science and Biotechnology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research
Daniel W. Shike
University of Illinois at Urbana-Champaign
Corresponding Author
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Background
Maternal nutrition during gestation affects fetal development, which has long-term programming effects on offspring postnatal growth performance. However, limited research is available for fetal programming effects of fatty acid supplementation on beef cattle. With a critical role in protein and lipid metabolism, essential fatty acids can influence the development of muscle and adipose tissue. The experiment investigated the effects of late gestation supplements, either rich in saturated and monounsaturated fatty acids (CON) or polyunsaturated fatty acids (PUFA), on cow performance and subsequent calf growth performance as well as gene expression in longissimus muscle (LM) and subcutaneous adipose tissue.
Results
There was no difference (P ≥ 0.32) in cow body weight (BW) or body condition score from pre-supplementation through weaning. There were treatment × time interactions (P ≤ 0.05) for plasma C18:3 and C20:4 concentrations, in which C18:3 and C20:4 of both CON and PUFA cows were greater at mid-supplementation than those at calving, while CON cows at birth had the intermediate concentrations. Cow plasma C20:0, C20:5, and C22:6 were increased (P ≤ 0.01) in PUFA. At birth, PUFA steers had greater (P = 0.01) plasma C20:5 and lower (P < 0.01) C18:2 and C18:1. No birth BW or milk production differences were detected (P ≥ 0.45), while CON steers had greater (P = 0.05) weaning BW and tended (P = 0.06) to have greater pre-weaning average daily gain compared to PUFA. There were treatment × time interactions (P ≤ 0.02) for MYH7 and C/EBPβ expressions in LM; expression of MYH7 was greatest in CON at birth, while C/EBPβ was greatest in PUFA steers at weaning. There tended (P = 0.06) to be a treatment × time effect for MYF5, in which expression was the greatest in CON steers at birth. Maternal supplementation of PUFA tended (P ≤ 0.10) to decrease MYOG expression in LM and ZFP423 expression in adipose tissue during the pre-weaning stage.
Conclusions
Late gestation PUFA supplementation decreased pre-weaning growth performance of the subsequent steer progeny compared to CON supplementation, which could have been a result of downregulated expression of myogenic genes during pre-weaning period.
Keywords
Beef cattle, carcass characteristics, fatty acids, fetal programming, late gestation
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Peer Review Timeline
CURRENT STATUS: Under Review
The most recent version of this article is available here.
No community comments so far
Editorial decision: Minor revision
On 16 Feb, 2021
Review #1 received
Received 14 Feb, 2021
Review #2 received
Received 11 Feb, 2021
Reviewer #2 agreed
On 10 Feb, 2021
Reviewer #1 agreed
On 08 Feb, 2021
Reviewers invited
Invitations sent on 07 Feb, 2021
Editor assigned
On 06 Feb, 2021
Submission checks complete
On 06 Feb, 2021
Editor invited
On 06 Feb, 2021
Version 1
Posted 15 Dec, 2020
No comments provided
Editorial decision: Major revision
On 30 Dec, 2020
Review #3 received
Received 23 Dec, 2020
Review #2 received
Received 21 Dec, 2020
Review #1 received
Received 17 Dec, 2020
Reviewer #2 agreed
On 10 Dec, 2020
Reviewer #3 agreed
On 10 Dec, 2020
Reviewers invited
Invitations sent on 10 Dec, 2020
Reviewer #1 agreed
On 10 Dec, 2020
First submitted
On 08 Dec, 2020
Editor assigned
On 08 Dec, 2020
Submission checks complete
On 08 Dec, 2020
Editor invited
On 08 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
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This preprint is under consideration at Journal of Animal Science and Biotechnology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Daniel W. Shike
University of Illinois at Urbana-Champaign
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
The most recent version of this article is available here.
No community comments so far
Editorial decision: Minor revision
On 16 Feb, 2021
Review #1 received
Received 14 Feb, 2021
Review #2 received
Received 11 Feb, 2021
Reviewer #2 agreed
On 10 Feb, 2021
Reviewer #1 agreed
On 08 Feb, 2021
Reviewers invited
Invitations sent on 07 Feb, 2021
Editor assigned
On 06 Feb, 2021
Submission checks complete
On 06 Feb, 2021
Editor invited
On 06 Feb, 2021
Version 1
Posted 15 Dec, 2020
No comments provided
Editorial decision: Major revision
On 30 Dec, 2020
Review #3 received
Received 23 Dec, 2020
Review #2 received
Received 21 Dec, 2020
Review #1 received
Received 17 Dec, 2020
Reviewer #2 agreed
On 10 Dec, 2020
Reviewer #3 agreed
On 10 Dec, 2020
Reviewers invited
Invitations sent on 10 Dec, 2020
Reviewer #1 agreed
On 10 Dec, 2020
First submitted
On 08 Dec, 2020
Editor assigned
On 08 Dec, 2020
Submission checks complete
On 08 Dec, 2020
Editor invited
On 08 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The most recent version of this article is available here.
Background
Maternal nutrition during gestation affects fetal development, which has long-term programming effects on offspring postnatal growth performance. However, limited research is available for fetal programming effects of fatty acid supplementation on beef cattle. With a critical role in protein and lipid metabolism, essential fatty acids can influence the development of muscle and adipose tissue. The experiment investigated the effects of late gestation supplements, either rich in saturated and monounsaturated fatty acids (CON) or polyunsaturated fatty acids (PUFA), on cow performance and subsequent calf growth performance as well as gene expression in longissimus muscle (LM) and subcutaneous adipose tissue.
Results
There was no difference (P ≥ 0.32) in cow body weight (BW) or body condition score from pre-supplementation through weaning. There were treatment × time interactions (P ≤ 0.05) for plasma C18:3 and C20:4 concentrations, in which C18:3 and C20:4 of both CON and PUFA cows were greater at mid-supplementation than those at calving, while CON cows at birth had the intermediate concentrations. Cow plasma C20:0, C20:5, and C22:6 were increased (P ≤ 0.01) in PUFA. At birth, PUFA steers had greater (P = 0.01) plasma C20:5 and lower (P < 0.01) C18:2 and C18:1. No birth BW or milk production differences were detected (P ≥ 0.45), while CON steers had greater (P = 0.05) weaning BW and tended (P = 0.06) to have greater pre-weaning average daily gain compared to PUFA. There were treatment × time interactions (P ≤ 0.02) for MYH7 and C/EBPβ expressions in LM; expression of MYH7 was greatest in CON at birth, while C/EBPβ was greatest in PUFA steers at weaning. There tended (P = 0.06) to be a treatment × time effect for MYF5, in which expression was the greatest in CON steers at birth. Maternal supplementation of PUFA tended (P ≤ 0.10) to decrease MYOG expression in LM and ZFP423 expression in adipose tissue during the pre-weaning stage.
Conclusions
Late gestation PUFA supplementation decreased pre-weaning growth performance of the subsequent steer progeny compared to CON supplementation, which could have been a result of downregulated expression of myogenic genes during pre-weaning period.
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