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Anahita Mansoori
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ORCiD: https://orcid.org/0000-0003-2935-9589
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Background Investigating effects of whole diets on non-alcoholic fatty liver disease can contribute to development of diet-based recommendations for prevention and treatment of this disease. the aim of the present study is the identification of major dietary patterns and their association with the risk of non-alcoholic fatty liver disease (NAFLD).
Methods A total of 244 individuals (122 NAFLD patients and 122 controls) participated in this case-control study. NAFLD patients were diagnosed by a gastroenterologist. Dietary intake data of participants were collected using a 147 item semi-quantitive food frequency questionnaire and major dietary patterns were identified by principal component analysis. The consumption of dietary patterns was divided into tertiles. The association of dietary patterns with the odds of NAFLD was investigated by multivariate logistic regression.
Results four major dietary patterns were recognized. The "ordinary pattern" adherence was positively associated with NAFLD risk. Although, results were statistically significant only for the third tertile versus the first tertile after adjusting for confounding factors (OR: 3.74, P-trend <0.001). Likewise, Adherence to the "traditional pattern" was associated with a higher risk for NAFLD. On the contrary, individuals in the third tertile of the "vegetable and dairy pattern" had a significantly decreased risk for NAFLD in comparison to the first tertile. Nevertheless, no significant association between "fast food type pattern" and the risk of NAFLD was found.
Conclusion there is a significant association between different dietary patterns and the risk of NAFLD. These results can potentially serve as a dietary strategy for the prevention of NAFLD in individuals who are at high risk for the progression of NAFLD.
Keywords
NAFLD, fatty liver, dietary pattern, factor analysis, Iran
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Editorial decision: Major revision
On 29 Apr, 2020
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Received 27 Apr, 2020
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Received 27 Apr, 2020
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Received 21 Apr, 2020
Reviewer #4 agreed
On 14 Apr, 2020
Reviewer #2 agreed
On 09 Apr, 2020
Reviewer #3 agreed
On 09 Apr, 2020
Review #1 received
Received 10 Mar, 2020
Reviewer #1 agreed
On 28 Feb, 2020
Editor assigned
On 26 Feb, 2020
Reviewers invited
Invitations sent on 26 Feb, 2020
Submission checks complete
On 25 Feb, 2020
Editor invited
On 25 Feb, 2020
Version 1
Posted 30 Jan, 2020
No comments provided
Editorial decision: Revise before peer review
On 29 Jan, 2020
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On 28 Jan, 2020
Submission checks complete
On 28 Jan, 2020
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On 27 Jan, 2020
First submitted
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Subject Areas
Nutrition & Dietetics
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A new preprint design is coming!
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See the published version of this preprint at Nutrition Journal.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Anahita Mansoori
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2935-9589
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Nutrition Journal.
No community comments so far
Reviewers invited
Invitations sent on 29 May, 2020
Reviewer #1 agreed
On 29 May, 2020
Reviewer #2 agreed
On 29 May, 2020
Editor assigned
On 28 May, 2020
Submission checks complete
On 27 May, 2020
Editor invited
On 27 May, 2020
No comments provided
Editorial decision: Major revision
On 29 Apr, 2020
Review #3 received
Received 27 Apr, 2020
Review #4 received
Received 27 Apr, 2020
Review #2 received
Received 21 Apr, 2020
Reviewer #4 agreed
On 14 Apr, 2020
Reviewer #2 agreed
On 09 Apr, 2020
Reviewer #3 agreed
On 09 Apr, 2020
Review #1 received
Received 10 Mar, 2020
Reviewer #1 agreed
On 28 Feb, 2020
Editor assigned
On 26 Feb, 2020
Reviewers invited
Invitations sent on 26 Feb, 2020
Submission checks complete
On 25 Feb, 2020
Editor invited
On 25 Feb, 2020
Version 1
Posted 30 Jan, 2020
No comments provided
Editorial decision: Revise before peer review
On 29 Jan, 2020
Editor assigned
On 28 Jan, 2020
Submission checks complete
On 28 Jan, 2020
Editor invited
On 27 Jan, 2020
First submitted
On 25 Jan, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Nutrition & Dietetics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Nutrition Journal.
Background Investigating effects of whole diets on non-alcoholic fatty liver disease can contribute to development of diet-based recommendations for prevention and treatment of this disease. the aim of the present study is the identification of major dietary patterns and their association with the risk of non-alcoholic fatty liver disease (NAFLD).
Methods A total of 244 individuals (122 NAFLD patients and 122 controls) participated in this case-control study. NAFLD patients were diagnosed by a gastroenterologist. Dietary intake data of participants were collected using a 147 item semi-quantitive food frequency questionnaire and major dietary patterns were identified by principal component analysis. The consumption of dietary patterns was divided into tertiles. The association of dietary patterns with the odds of NAFLD was investigated by multivariate logistic regression.
Results four major dietary patterns were recognized. The "ordinary pattern" adherence was positively associated with NAFLD risk. Although, results were statistically significant only for the third tertile versus the first tertile after adjusting for confounding factors (OR: 3.74, P-trend <0.001). Likewise, Adherence to the "traditional pattern" was associated with a higher risk for NAFLD. On the contrary, individuals in the third tertile of the "vegetable and dairy pattern" had a significantly decreased risk for NAFLD in comparison to the first tertile. Nevertheless, no significant association between "fast food type pattern" and the risk of NAFLD was found.
Conclusion there is a significant association between different dietary patterns and the risk of NAFLD. These results can potentially serve as a dietary strategy for the prevention of NAFLD in individuals who are at high risk for the progression of NAFLD.
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