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Association of the Dietary Patterns with the Risk of Non-alcoholic Fatty Liver Disease among Iranian Population: A case-control study
Anahita Mansoori
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2935-9589
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at Nutrition Journal.
Background: Diet-based recommendations can be developed for preventing and treating non-alcoholic fatty liver disease (NAFLD) after investigating the effects of whole diets on NAFLD. The aim of this study was to identify major dietary patterns and their association with the risk of NAFLD.
Methods: A total of 244 individuals (122 NAFLD patients and 122 controls) participated in this case-control study. The NAFLD patients were diagnosed by a gastroenterologist. The participants' dietary intake data were collected using a 147-item semi-quantitive food frequency questionnaire and major dietary patterns were identified by principal component analysis. Adherence to dietary patterns was divided into tertiles and its association with odds of NAFLD was investigated by multivariate logistic regression.
Results: The results showed four major dietary patterns, among which adherence to the
"ordinary pattern" was positively associated with NAFLD risk. After adjusting for all confounding factors, individuals in the highest tertile of "ordinary pattern" exhibited a significantly elevated risk of NAFLD compared to the lowest tertile (OR= 3.74, 95%CI= 1.23-11.42, P trend<0.001). As well as, Individuals in the second and third tertiles of the "traditional pattern" were associated with the risk of NAFLD compared to the lowest tertile (medium vs. lowest tertile OR= 2.37, 95%CI= 1.02-5.53; highest vs. lowest tertile OR=3.58, 95% CI= 1.48-8.68, P trend<0.001). The highest tertile of "vegetable and dairy pattern" compared to the lowest tertile was inversely associated with NAFLD risk (OR= 0.23, 95%CI= 0.09-0.58, P trend=0.02). No significant association was found between "fast food type pattern" and the risk of NAFLD.
Conclusion: A significant association was observed between different dietary patterns and the risk of NAFLD. These results can potentially serve as a dietary strategy for preventing NAFLD in individuals who are at a high risk for progression of NAFLD.
Keywords
NAFLD, Fatty liver, Dietary pattern, Factor analysis, Iran
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CURRENT STATUS: Published
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Posted 04 Jun, 2020
Published
On 30 Jun, 2020
No community comments so far
Reviewers invited
Invitations sent on 29 May, 2020
Reviewer #1 agreed
On 29 May, 2020
Reviewer #2 agreed
On 29 May, 2020
Editor assigned
On 28 May, 2020
Submission checks complete
On 27 May, 2020
Editor invited
On 27 May, 2020
No comments provided
Editorial decision: Major revision
On 29 Apr, 2020
Review #3 received
Received 27 Apr, 2020
Review #4 received
Received 27 Apr, 2020
Review #2 received
Received 21 Apr, 2020
Reviewer #4 agreed
On 14 Apr, 2020
Reviewer #2 agreed
On 09 Apr, 2020
Reviewer #3 agreed
On 09 Apr, 2020
Review #1 received
Received 10 Mar, 2020
Reviewer #1 agreed
On 28 Feb, 2020
Editor assigned
On 26 Feb, 2020
Reviewers invited
Invitations sent on 26 Feb, 2020
Submission checks complete
On 25 Feb, 2020
Editor invited
On 25 Feb, 2020
No comments provided
Editorial decision: Revise before peer review
On 29 Jan, 2020
Editor assigned
On 28 Jan, 2020
Submission checks complete
On 28 Jan, 2020
Editor invited
On 27 Jan, 2020
First submitted
On 25 Jan, 2020
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Subject Areas
Nutrition & Dietetics
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This preprint is under consideration at Nutrition Journal. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Association of the Dietary Patterns with the Risk of Non-alcoholic Fatty Liver Disease among Iranian Population: A case-control study
Anahita Mansoori
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2935-9589
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 3
Posted 04 Jun, 2020
Published
On 30 Jun, 2020
No community comments so far
Reviewers invited
Invitations sent on 29 May, 2020
Reviewer #1 agreed
On 29 May, 2020
Reviewer #2 agreed
On 29 May, 2020
Editor assigned
On 28 May, 2020
Submission checks complete
On 27 May, 2020
Editor invited
On 27 May, 2020
No comments provided
Editorial decision: Major revision
On 29 Apr, 2020
Review #3 received
Received 27 Apr, 2020
Review #4 received
Received 27 Apr, 2020
Review #2 received
Received 21 Apr, 2020
Reviewer #4 agreed
On 14 Apr, 2020
Reviewer #2 agreed
On 09 Apr, 2020
Reviewer #3 agreed
On 09 Apr, 2020
Review #1 received
Received 10 Mar, 2020
Reviewer #1 agreed
On 28 Feb, 2020
Editor assigned
On 26 Feb, 2020
Reviewers invited
Invitations sent on 26 Feb, 2020
Submission checks complete
On 25 Feb, 2020
Editor invited
On 25 Feb, 2020
No comments provided
Editorial decision: Revise before peer review
On 29 Jan, 2020
Editor assigned
On 28 Jan, 2020
Submission checks complete
On 28 Jan, 2020
Editor invited
On 27 Jan, 2020
First submitted
On 25 Jan, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Nutrition & Dietetics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at Nutrition Journal.
Background: Diet-based recommendations can be developed for preventing and treating non-alcoholic fatty liver disease (NAFLD) after investigating the effects of whole diets on NAFLD. The aim of this study was to identify major dietary patterns and their association with the risk of NAFLD.
Methods: A total of 244 individuals (122 NAFLD patients and 122 controls) participated in this case-control study. The NAFLD patients were diagnosed by a gastroenterologist. The participants' dietary intake data were collected using a 147-item semi-quantitive food frequency questionnaire and major dietary patterns were identified by principal component analysis. Adherence to dietary patterns was divided into tertiles and its association with odds of NAFLD was investigated by multivariate logistic regression.
Results: The results showed four major dietary patterns, among which adherence to the
"ordinary pattern" was positively associated with NAFLD risk. After adjusting for all confounding factors, individuals in the highest tertile of "ordinary pattern" exhibited a significantly elevated risk of NAFLD compared to the lowest tertile (OR= 3.74, 95%CI= 1.23-11.42, P trend<0.001). As well as, Individuals in the second and third tertiles of the "traditional pattern" were associated with the risk of NAFLD compared to the lowest tertile (medium vs. lowest tertile OR= 2.37, 95%CI= 1.02-5.53; highest vs. lowest tertile OR=3.58, 95% CI= 1.48-8.68, P trend<0.001). The highest tertile of "vegetable and dairy pattern" compared to the lowest tertile was inversely associated with NAFLD risk (OR= 0.23, 95%CI= 0.09-0.58, P trend=0.02). No significant association was found between "fast food type pattern" and the risk of NAFLD.
Conclusion: A significant association was observed between different dietary patterns and the risk of NAFLD. These results can potentially serve as a dietary strategy for preventing NAFLD in individuals who are at a high risk for progression of NAFLD.