This preprint is under consideration at Italian Journal of Pediatrics. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Risk factors for post-transplant lymphoproliferative disorder after pediatric liver transplantation in China
Zhao-hui Deng
Shanghai Childrens Medical Center Affiliated to Shanghai Jiaotong University School of Medicine
Corresponding Author
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Objectives: This study aimed to analyze the risk factors associated with post-transplant lymphoproliferative disorder (PTLD) after liver transplantation in children.
Methods: We retrospectively analyzed the clinical and laboratory data of patients treated and followed up at Shanghai Children's Medical Center between January 2012 and January 2019. Twenty-four patients with PTLD were enrolled in this study using a 1:2 pairing design. Each case was matched with two controls that had undergone liver transplantation within the same year but did not develop PTLD during the follow-up period. A total of 72 patients were included in this study.
Results: Univariate analysis demonstrated statistically significant differences in Epstein-Barr virus (EBV) infection, tacrolimus blood concentration, Platelet (PTL), Aspartate aminotransferase(AST),Alanine aminotransferase (ALT), and Cholesterol(CHOL).Multivariate logistics regression analysis revealed that EBV
infection was an independent risk factor for PTLD.
Conclusions: EBV infection is an independent risk factor for PTLD. When uncontrolled proliferation of EBV occurs after organ transplantation, the dosage of immunosuppressive agents should be appropriately reduced.
Keywords
risk factors, post-transplant lymphoproliferative disorder, liver transplantation
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CURRENT STATUS: Under Review
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Posted 16 Dec, 2020
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Invitations sent on 18 Jan, 2021
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This preprint is under consideration at Italian Journal of Pediatrics. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Risk factors for post-transplant lymphoproliferative disorder after pediatric liver transplantation in China
Zhao-hui Deng
Shanghai Childrens Medical Center Affiliated to Shanghai Jiaotong University School of Medicine
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 16 Dec, 2020
No community comments so far
Reviewers invited
Invitations sent on 18 Jan, 2021
Editor assigned
On 24 Dec, 2020
Editor invited
On 24 Dec, 2020
Submission checks complete
On 14 Dec, 2020
First submitted
On 12 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objectives: This study aimed to analyze the risk factors associated with post-transplant lymphoproliferative disorder (PTLD) after liver transplantation in children.
Methods: We retrospectively analyzed the clinical and laboratory data of patients treated and followed up at Shanghai Children's Medical Center between January 2012 and January 2019. Twenty-four patients with PTLD were enrolled in this study using a 1:2 pairing design. Each case was matched with two controls that had undergone liver transplantation within the same year but did not develop PTLD during the follow-up period. A total of 72 patients were included in this study.
Results: Univariate analysis demonstrated statistically significant differences in Epstein-Barr virus (EBV) infection, tacrolimus blood concentration, Platelet (PTL), Aspartate aminotransferase(AST),Alanine aminotransferase (ALT), and Cholesterol(CHOL).Multivariate logistics regression analysis revealed that EBV
infection was an independent risk factor for PTLD.
Conclusions: EBV infection is an independent risk factor for PTLD. When uncontrolled proliferation of EBV occurs after organ transplantation, the dosage of immunosuppressive agents should be appropriately reduced.