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belete Beyene
Academia Sinica
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7662-1917
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This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Chemistry.
In this study, we report antibacterial activity of metalloporphyrins; 5, 10, 15, 20-tetrakis ( para -X phenyl)porphyrinato M (II) [where X= H, NH 2 and COOMe for M = Cu and X= COOH and OMe for M = Co] . The activity study of the as-synthesized metalloporphyrins toward two Gram-positive ( S. aureus and S. pyogenes) and two Gram-negative ( E. coli and K. pneumoniae ) bacteria showed a promising inhibitory activity . Among the complexes under study, the highest antibacterial activity is observed for 5, 10, 15, 20-tetrakis (p-carboxyphenyl)porphyrinato cobalt (II), with inhibition zone of 16.5mm against Staphylococcus aureus ( S. aureus ). This activity could be attributed to the high binding ability of COOH group to cellular components, membranes, proteins, and DNA as well as the lipophilicity of the complex. Moreover, consistent with literature report, the study revealed that metalloporphyrins with electron withdrawing group at para-positions have better antibacterial activity than metalloporphyrin which possess electron donating group at para position.
Keywords
Cobalt porphyrin, inhibition, copper porphyrin, antibacterial activity, lipophilicity,
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CURRENT STATUS: Published
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Posted 30 Jul, 2020
Published
On 14 Aug, 2020
No community comments so far
Editorial decision: Accept
On 07 Jul, 2020
Review #3 received
Received 25 Jun, 2020
Review #2 received
Received 25 Jun, 2020
Review #1 received
Received 15 Jun, 2020
Reviewer #3 agreed
On 14 Jun, 2020
Reviewers invited
Invitations sent on 12 Jun, 2020
Reviewer #1 agreed
On 12 Jun, 2020
Reviewer #2 agreed
On 12 Jun, 2020
Editor assigned
On 11 Jun, 2020
Submission checks complete
On 10 Jun, 2020
Editor invited
On 10 Jun, 2020
No comments provided
Editorial decision: Major revision
On 20 May, 2020
Review #4 received
Received 06 Apr, 2020
Review #3 received
Received 03 Apr, 2020
Review #2 received
Received 30 Mar, 2020
Review #1 received
Received 30 Mar, 2020
Reviewer #4 agreed
On 22 Mar, 2020
Reviewer #3 agreed
On 19 Mar, 2020
Reviewer #2 agreed
On 18 Mar, 2020
Reviewers invited
Invitations sent on 15 Mar, 2020
Reviewer #1 agreed
On 15 Mar, 2020
Editor assigned
On 09 Mar, 2020
Submission checks complete
On 08 Mar, 2020
Editor invited
On 08 Mar, 2020
No comments provided
Editorial decision: Revise Before Review
On 24 Feb, 2020
Editor assigned
On 14 Feb, 2020
Submission checks complete
On 13 Feb, 2020
Editor invited
On 13 Feb, 2020
No comments provided
Editorial decision: Revise Before Review
On 31 Jan, 2020
Editor assigned
On 28 Jan, 2020
Submission checks complete
On 27 Jan, 2020
Editor invited
On 27 Jan, 2020
First submitted
On 13 Jan, 2020
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Subject Areas
General Biochemistry
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This preprint is under consideration at BMC Chemistry. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
belete Beyene
Academia Sinica
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7662-1917
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 4
Posted 30 Jul, 2020
Published
On 14 Aug, 2020
No community comments so far
Editorial decision: Accept
On 07 Jul, 2020
Review #3 received
Received 25 Jun, 2020
Review #2 received
Received 25 Jun, 2020
Review #1 received
Received 15 Jun, 2020
Reviewer #3 agreed
On 14 Jun, 2020
Reviewers invited
Invitations sent on 12 Jun, 2020
Reviewer #1 agreed
On 12 Jun, 2020
Reviewer #2 agreed
On 12 Jun, 2020
Editor assigned
On 11 Jun, 2020
Submission checks complete
On 10 Jun, 2020
Editor invited
On 10 Jun, 2020
No comments provided
Editorial decision: Major revision
On 20 May, 2020
Review #4 received
Received 06 Apr, 2020
Review #3 received
Received 03 Apr, 2020
Review #2 received
Received 30 Mar, 2020
Review #1 received
Received 30 Mar, 2020
Reviewer #4 agreed
On 22 Mar, 2020
Reviewer #3 agreed
On 19 Mar, 2020
Reviewer #2 agreed
On 18 Mar, 2020
Reviewers invited
Invitations sent on 15 Mar, 2020
Reviewer #1 agreed
On 15 Mar, 2020
Editor assigned
On 09 Mar, 2020
Submission checks complete
On 08 Mar, 2020
Editor invited
On 08 Mar, 2020
No comments provided
Editorial decision: Revise Before Review
On 24 Feb, 2020
Editor assigned
On 14 Feb, 2020
Submission checks complete
On 13 Feb, 2020
Editor invited
On 13 Feb, 2020
No comments provided
Editorial decision: Revise Before Review
On 31 Jan, 2020
Editor assigned
On 28 Jan, 2020
Submission checks complete
On 27 Jan, 2020
Editor invited
On 27 Jan, 2020
First submitted
On 13 Jan, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
General Biochemistry
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Chemistry.
In this study, we report antibacterial activity of metalloporphyrins; 5, 10, 15, 20-tetrakis ( para -X phenyl)porphyrinato M (II) [where X= H, NH 2 and COOMe for M = Cu and X= COOH and OMe for M = Co] . The activity study of the as-synthesized metalloporphyrins toward two Gram-positive ( S. aureus and S. pyogenes) and two Gram-negative ( E. coli and K. pneumoniae ) bacteria showed a promising inhibitory activity . Among the complexes under study, the highest antibacterial activity is observed for 5, 10, 15, 20-tetrakis (p-carboxyphenyl)porphyrinato cobalt (II), with inhibition zone of 16.5mm against Staphylococcus aureus ( S. aureus ). This activity could be attributed to the high binding ability of COOH group to cellular components, membranes, proteins, and DNA as well as the lipophilicity of the complex. Moreover, consistent with literature report, the study revealed that metalloporphyrins with electron withdrawing group at para-positions have better antibacterial activity than metalloporphyrin which possess electron donating group at para position.
Figure 1
Figure 2
Figure 3
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