The Effect of Long-Haul COVID Towards Domains of The Health Related Quality of Life Among Recovered Hospitalized Patients

Background People with long-haul COVID could experience various health problems, from mild to more severe ones. This research aimed to identify the effect of long-haul COVID, speci�cally on the Quality of Life domains, experienced by COVID 19 survivor. Data collection was carried out online, using data from DKI Jakarta hospitalized patients who have been con�rmed with and recovered from SARS-CoV-2 infections. We selected patients who have a minimum of 28 days after being hospitalized for COVID 19 positive. Logistic regression technique was used to analyze the data. The questionnaire used in this research was measured by WHOQOL-BREF. The WHOQOL-BREF is a self-administered questionnaire comprising 26 questions on the individual's perceptions of their health and well-being over the previous two weeks. Prior to the data collection, we tested the questionnaire with 30 recovered patients who were hospitalized outside DKI Jakarta.


Introduction
Long-Haul COVID, also known as post-COVID syndrome, post-acute sequelae of COVID 19 (PASC), or chronic COVID 19 syndrome (CCS), is a condition characterized by long-haul term sequelae appearing or persisting after the typical convalescence period of COVID-19.[1] Long-haul COVID can affect nearly every organ system with a wide range of symptoms are commonly discussed, including fatigue, headaches, shortness of breath, anosmia, parosmia, muscle weakness, low fever and cognitive dysfunction.sequelae, nervous system and neurocognitive disorders, mental health disorders, metabolic disorders, cardiovascular disorders, gastrointestinal disorders, malaise, fatigue, musculoskeletal pain, and anemia.[2][3][4] [5] The long-haul COVID tends to occur more frequently in survivors who have more severe symptoms during infection.[7] The effectiveness of treatment measures to treat this condition is still being sought.These conditions can be associated with health-related quality of life have become an important issue in medical and psychological research.WHO de nes quality of life as individuals' perceptions of their position in life in the context of the culture and value systems in which they live, as well as in relation to their goals, expectations, standards, and concerns.[8]WHO has assessed the quality of life through the WHOQOL-100 questionnaire which is a multidimensional evaluation of individuals' perceptions of their health status, psychosocial status, and other aspects of their lives.[9] Subsequently, WHO created a simpli ed version of WHOQOL-100 called the WHOQOL-BREF.[10) The WHOQOL-BREF questionnaire can be completed independently by the respondent or with the assistance of a trained interviewer.[8][10] WHOQOL-BREF demonstrated good discriminant validity, content validity, internal consistency, and retest reliability, and was highly correlated with WHOQOL-100 domain scores.[10], [11] [12] The Indonesian version of the WHOQOL-BREF instrument showed a near-perfect match of the two general items and good agreement of the four domains.Therefore it can be concluded that the WHOQOL-BREF is a consistent and stable instrument to measure the quality of life of Indonesian people in general.[13] [14] [15].Therefore, further in-depth studies are needed to examine the health problems in COVID 19 patients who have been declared cured after being discharged from the hospital.Thus, this research has aimed to identify the effect of Long-Haul COVID symptoms on the Quality of Life of Recovered Patients in Hospitals in Jakarta.It is expected that the results of this research could be used to strengthen post-hospitalization supervision for recovered patients.

Research Method
The research related to the long-haul COVID had passed an ethical permit and data collection permit from the DKI Health O ce for 6 months.The research was conducted in DKI Jakarta, the capital of Indonesia and the center of the COVID 19 spread in Indonesia.Due to conditions that did not allow for the data to be collected directly, data collection was conducted online using a database from reports of COVID 19 patients from various hospitals and health centers.The respondents were randomly selected from a list of COVID 19 patients who had recovered.This list was provided by the Provincial Health O ce of DKI Jakarta.
Several di culties, such as a slow pace of data collection, as some patients who had recovered from COVID 19 refused to ll out online surveys, were encountered during the implementation.Eventually, only 281 respondents were obtained.The database of COVID 19 patient reports from various hospitals and health centers were also not well organized and some of the data reported were incomplete.After data cleaning and making sure that the respondents met the inclusion criteria (aged 18 or more, were hospitalized patients, and interviewed a minimum of 28 days after hospitalized COVID 19 positive) and properly lled out the form, the total number of respondents was 172.
There are many terms to describe the symptoms of The Long-Haul COVID and how to assess them too.Long-Haul COVID, as the main independent variable in this study, followed the term with a history of con rmed SARS-CoV-2 infection, at an interview at least 28 days after completion of hospitalization for COVID 19 positive patients with symptoms who did not have the experience before becoming sick.Other independent variables, including gender, age, length of treatment, length from onset to interview, marital status, occupation, and respirator use, were determined as covariates.The WHOQOL-BREF, was utilized to measure the dependent variable of this research: Quality of Life.
The four major domains assessed in the WHOQOL-BREF can be described as: 1. Physical Domain Score with 7 items, 2. Psychological health with 6 items, 3.
Social relationships with 3 items (Personal relationships; Sexual activity; Social support) and 4 Environmental health with 8 items.The responses to the questions are on a 1-5 Likert scale where 1 represents "disagree" or "not at all" and 5 represents "completely agree" or "extremely".

Result
Based on data from 172 participants in this research, table 1 shows the mean length of treatment (days) was 15.17 ± 8, while the mean length of the gap from baseline to interview (days) was 109.22 ± 69.71.Out of four quality of life domains, the lowest mean score was identi ed in the physical domain with 69.31 ± 12.31, while the highest score was indicated at the social domain with the mean of 78.29 ± 16.08.The mean score of the psychological and the environmental domain were 74.89 ± 11.70 and 73.60 ± 13.30, respectively.

Demographic characteristics
Table 2 describes the demographic characteristics of participants in this research.The proportion of males (48.3%) and females (51.7%) in this research tended to be equal.The majority of participants were aged 18-39 years (58,.1%),married or living with partners (66.9%), and working in the private sector (55.2%).Out of 172 participants, only 20 (11.6%) used respiratory aids during their COVID-19 treatment.Among all participants, almost one-third (30.2%) experienced long-haul symptoms of COVID symptoms, with 23.8% were having one symptom, and 6.4% were having two or more symptoms.
Further information on long-haul COVID are seen in Table 3. From eleven (11) symptoms that were collected, most of the participants experienced fatigue (16.3%), chest pain (7%), coughing (4.1%), breathing trouble (2.9%), as well as digestive disorder and headache (2.3%).There were one to two participants who experienced other symptoms such as ageusia, anosmia, memory loss, nausea, and joint pain.Table 4 presents a comparison of the average scores for each quality of life domain according to socio-demography, treatment history, and having Long-Haul COVID symptoms.The Comparison of the average of scores domains in Quality of life can be described that there was a difference in the average score of the social domain male higher rather than female groups (p-value 0.03).In the 18-39 year age group, the average psychological domain score was higher than the 40-year-old age group or older (p-valu0.03).On the marital status of the participants, those who were married or living with a partner had a higher average psychological domain score than those from the single or divorced group (p-value 0.007).On the variable duration of treatment, there was no signi cant difference in the average in all domains of Quality of Life.However, regarding the use of breathing during COVID-19 treatment, the two Quality of Life domains (Psychological and Environmental) have a signi cant average difference with p-values of 0.01 and 0.02, respectively.The other variables were not proven to be signi cant.
In Table 5, the Quality of Life variable was categorized into two categories (good and poor), as the scores were not normally distributed.Table 5 shows female participants, those aged 40 years or more, divorced/single participants, and unemployed participants tend to have a poorer quality of life in the physical domain.People with two or more symptoms of Long-Haul COVID also tended to have a poor quality of life in the physical domain compared to those without long-haul symptoms (OR=2.54,95% CI = 0.68 -9.46).
In the psychological domain, participants aged 40 years or more and participants with 14 or more days of treatment were two-fold more at risk to experience poor quality of life compared to their counterparts.Participants with two or more Long-Haul COVID symptoms also tended to have a higher risk for poorer quality of health in the psychological domain, with an odds ratio of 2.44 (95% CI = 0.46 -12.89), compared to those who showed no symptoms.
In the social domain, people with one Long-Haul COVID symptoms have a higher risk, by almost two times, compared to those with no symptoms (OR = 1.97, 95%CI = 0.79 -4.92).In contradictory, Long-Haul COVID symptoms tended to be protective against the poor quality of life compared to those with no symptoms, in terms of the environmental domain.Thus, these initial results need to be analyzed further using multivariate analysis, as seen in Table 6.Multivariate analysis with four models was presented in this research.In which, each model has one dependent variable from each domain of the Quality of Life.
After adjusted with other variables, people with Long-Haul COVID tend to be at a greater risk to have a poor quality of life in the physical domain, psychological domain, and social domain with an odds ratio of 1.93 (95% CI = 0.88 -4.23), 2.62 (95% CI = 0.96 -7.14), and 2.09 (95% CI = 0.85 -5.12), respectively.With an odd ratio of 0.99, the effect of Long-Haul COVID symptoms could not be concluded in the environmental domain.

Discussion
The limitations of this research The limitation of this research is that the symptoms reported by the subjects were obtained through online questionnaires due to the government eldwork.
Therefore, these symptoms are subjective according to the perception of each individual.This research has a large proportion in the relatively young age group (under 40 years).Thus, persistent variation in symptoms according to age remains unknown.Notwithstanding that the patients are young and have a lower epidemiological propensity for chronic diseases and other degenerative symptoms, the symptoms of those who complain have a lower risk of the consequences of the chronic disease.

The strength of this research
Many people experience prolonged symptoms, poor health, and reduced function for months, even though they are not hospitalized for SARS-CoV-2 infection.
This study explores the health condition of COVID 19 patients after discharge from the hospital and emphasizes the need for post-hospital surveillance as a necessity, as well as building sustainable health services as a recovery response from a quality of life perspective.
Long-Haul COVID and Quality of life Quality of life is currently de ned as a multidimensional concept consisting of a number of domains that people consider and evaluate differently according to the importance they attach to each domain in their lives.[17] In the condition of post-covid patients, it is interesting to explore the relationship with the four domains in the WHOQOL BREF as Quality of Life instrument.[8][This is important to clarify the post-hospital care steps that should be taken in upholding complete health related to the quality of life.
Furthermore, based on Epidemiological and immunological-based studies of recovered COVID 19 patients, it can be utilized to monitor their health status for possible future complications.[2][16] Observational investigations in larger cohorts will help us understand the deep prognosis and pathogenesis of COVID 19 disease.Studies of this kind will help uncover whether patients recovering from COVID 19 require post-acute care to recover from further infection or multiorgan damage.[18]SARS-CoV-2 mainly affects people who are immunocompromised and have previous medical conditions (problems related to the lungs, kidneys, heart, and digestive tract).[19][20] Our research showed that almost one-third (30.2%) experienced long-haul symptoms of COVID 19, with 23.8% experiencing one symptom and 6.4% experiencing two or more symptoms, in which most of them have experienced fatigue, chest pain, coughing, breathing trouble, digestive disorder and headache (16.3%; 7%; 4.1%; 2.9%; 2.3%), respectively.Further, after the Quality of Life variable was categorized into two categories (good and poor), it was implied how the long-haul symptoms affect all domains, except for the environmental one.It was found that those who had remote covid symptoms and had more than one symptom are at approximately double the risk of having poor quality of life compared with those without symptoms.In addition, the risk of having a bad quality of life varied greatly depending on the predominance.However, the increasing risk of having poor quality of life from the use of respirators is seen in none of the domains.Respondents aged 40 years or over are more at risk of having poor quality of life in physical and psychological aspects of Quality of Life.In addition, women and unmarried or divorced respondents are also at risk of having poor quality of life in the physical domain.Length of stay of more than 14 days also renders poor Quality of Life in the psychological domain.In the social domain, unmarried or divorced status, as well as the type of work seems to affect the risk of having poor quality of life.In the environmental domain, women respondents, those with single or divorced status, and those with a length of stay of more than 14 days are at risk of having a bad quality of life.
Results of multivariate analysis implied that Long-Haul COVID patients tend to have a greater risk of having poor Quality of Life in the physical domain, psychological domain, and social domain with odds ratios of 1.93 (95% CI = 0.88 -4.23), 2.62 (95% CI = 0.96 -7.14), and 2.09 (95% CI = 0.85 -5, 12).The environmental domain has an odd ratio of 0.99, which seems to be a protective effect for poor Quality of Life.The signi cant impact of the emergence of Long-Haul COVID on recovered patients con rmed the association between the Long-Haul COVID and the WHOQOL-BREF Quality of lIFE domains.[21] The ndings are essential to clarify the necessary steps for post-hospital care that need to be taken to create a whole and quality-related health [22][23].

Conclusion
Those who have recovered from COVID-19 still have health problems such as long-haul COVID 19 symptoms.Many of them are also related to the reduction of the quality of life domain.If left untreated, they will continue to experience long-term health complications.Therefore, robust post-hospital surveillance is needed to identify the need for related health services.

Declarations Ethics approval and consent to participate
This study obtained ethical clearance from Universitas Indonesia's Ethics Committee, with Ethical Approval number: 593/UN2.F10.D11/PPM.00.02/2020 Patient consent for publication

Informed consent
Informed consent was given in the beginning of the questionnaire, in which participants agreed or declined to take part in the study.

Availability of data and materials
Tables

Table 1 .
Descriptive statistics of Length of Treatment, Length from Onset to Interview, Quality of Life domains,

Table 2 .
The Demographic characteristics, History of treatments and The Long-Haul COVID 19

Table 3 .
The list of The Long-Haul COVID 19 symptomps

Table 4 .
The quality of life domain scores for sociodemographic and health-related predictors

Table 5 .
The association of quality of life domain category related by sociodemographic and health-related predictors

Table 6 .
Results of Multivariable analysis of Quality of Life Domains and Gender, Age Group, Marital Status, Occupation and Having Long-Haul COVID 19