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Research
Association of DIO2 Thr92Ala Polymorphism With Pediatric Obesity In Japanese Children: A Case Control Study
Jun Mori
Kyoto Prefectural University of Medicine: Kyoto Furitsu Ika Daigaku
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1271-1577
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Genetic factors play a critical role in the onset and progression of obesity. Brown adipose tissue (BAT) activity is also critical for adiposity. The objective of this study was to evaluate the prevalence and effects of gene polymorphisms related to BAT in pediatric obesity.
Methods
A case-control study with 270 non-obese and 86 obese children was performed. All participants underwent genotyping of type 2 deiodinase (DIO2) Thr92Ala (rs225014), uncoupling protein 1 (UCP1) -3826 A/G (rs1800592), and β3 adrenergic receptor (β3AR) Trp64Arg (rs4994).
Results
In the case-control study, the prevalence of the homozygous Ala/Ala allele of the DIO2 gene in the obese group was 15.1 % versus 6.3 % in the non-obese group, resulting in an odds ratio (OR) of 3.393 (95% confidence intervals [CI], 1.498-7.687, P = 0.003). The genotype distribution of UCP1-3826 A/G and ß3AR Trp64Arg did not significantly differ between the obese and the non-obese groups, and the ORs were 1.831 (95% CI, 0.955-3.512, P = 0.069) and 0.819 (95% CI, 0.263-2.555, P = 0.731), respectively.
Conclusions
Our results indicate that the homozygous Ala/Ala allele of the DIO2 gene is associated with an increased risk of obesity in children.
Keywords
obesity, BAT, DIO2, UCP1, β3 adrenergic receptor
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This is a preprint. It has not completed peer review.
Research
Association of DIO2 Thr92Ala Polymorphism With Pediatric Obesity In Japanese Children: A Case Control Study
Jun Mori
Kyoto Prefectural University of Medicine: Kyoto Furitsu Ika Daigaku
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1271-1577
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 28 Dec, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Genetic factors play a critical role in the onset and progression of obesity. Brown adipose tissue (BAT) activity is also critical for adiposity. The objective of this study was to evaluate the prevalence and effects of gene polymorphisms related to BAT in pediatric obesity.
Methods
A case-control study with 270 non-obese and 86 obese children was performed. All participants underwent genotyping of type 2 deiodinase (DIO2) Thr92Ala (rs225014), uncoupling protein 1 (UCP1) -3826 A/G (rs1800592), and β3 adrenergic receptor (β3AR) Trp64Arg (rs4994).
Results
In the case-control study, the prevalence of the homozygous Ala/Ala allele of the DIO2 gene in the obese group was 15.1 % versus 6.3 % in the non-obese group, resulting in an odds ratio (OR) of 3.393 (95% confidence intervals [CI], 1.498-7.687, P = 0.003). The genotype distribution of UCP1-3826 A/G and ß3AR Trp64Arg did not significantly differ between the obese and the non-obese groups, and the ORs were 1.831 (95% CI, 0.955-3.512, P = 0.069) and 0.819 (95% CI, 0.263-2.555, P = 0.731), respectively.
Conclusions
Our results indicate that the homozygous Ala/Ala allele of the DIO2 gene is associated with an increased risk of obesity in children.
Figure 1
Figure 2