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Research Article
Matej Štuhec
University of Maribor
Corresponding Author
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Potentially inappropriate medications (PIMs) are highly prevalent in elderly patients with mental disorders (MPHs) treated with polypharmacy. This study's main aim was to determine the impact of a clinical pharmacist (CP)’s recommendations on the total number of PIMs and to evaluate the differences in PIMs between two patient subgroups with mental disorders with either fully or partially accepted recommendations that have not been studied until now.
A retrospective observational cohort study involving primary care patients aged 65 or above in 2015–2017 was conducted. To evaluate the impact of the interventions on the number of PIMs, odds ratios (ORs) were used. Ninety-nine patients were included (79.4 y, SD=7.92). At least one PIM was present in 69.7% or 92.9% of the patients (PRISCUS and Beers list). The interventions led to a 21.2% decrease (n=23; PRISCUS) and a 17.3% decrease (n=38; Beers) (p<0.05). The ORs for PIMs were significantly smaller in the full-acceptance subgroup (OR=3.8, CI 1.4-10.1; Beers) and insignificantly smaller for another group (OR=2.8, CI 1.0-8.2; PRISCUS). The CP's interventions decreased the number of PIMs according to the PRISCUS and the Beers list, and ORs for PIMs decreased if all proposed interventions were accepted.
Keywords
elderly patients, mental disorders, potentially inappropriate medication, clinical pharmacist, medical review.
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Matej Štuhec
University of Maribor
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 04 Jan, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Potentially inappropriate medications (PIMs) are highly prevalent in elderly patients with mental disorders (MPHs) treated with polypharmacy. This study's main aim was to determine the impact of a clinical pharmacist (CP)’s recommendations on the total number of PIMs and to evaluate the differences in PIMs between two patient subgroups with mental disorders with either fully or partially accepted recommendations that have not been studied until now.
A retrospective observational cohort study involving primary care patients aged 65 or above in 2015–2017 was conducted. To evaluate the impact of the interventions on the number of PIMs, odds ratios (ORs) were used. Ninety-nine patients were included (79.4 y, SD=7.92). At least one PIM was present in 69.7% or 92.9% of the patients (PRISCUS and Beers list). The interventions led to a 21.2% decrease (n=23; PRISCUS) and a 17.3% decrease (n=38; Beers) (p<0.05). The ORs for PIMs were significantly smaller in the full-acceptance subgroup (OR=3.8, CI 1.4-10.1; Beers) and insignificantly smaller for another group (OR=2.8, CI 1.0-8.2; PRISCUS). The CP's interventions decreased the number of PIMs according to the PRISCUS and the Beers list, and ORs for PIMs decreased if all proposed interventions were accepted.
Figure 1
Figure 2
Figure 3
Figure 4
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