Background: The non-invasive assessment of steatosis/fibrosis tried to overcome some of periprocedural risk of liver biopsy; for this several indices of steatosis and fibrosis in liver have been proposed. Aim: to evaluate concordance of non invasive fibrosis and steatosis indices in a large population of adult subjects at risk of NAFLD, and their relationship with different clinical and biochemical parameters.
Methods: Indices of steatosis (fatty liver index-FLI), NAFLD liver fat score-NLFS)) and fibrosis (Fibrosis 4 (FIB-4), BARD, BAAT and FORN) were calculated in 1145 outpatients with overweight or obesity at risk for T2D and NAFLD. Indices were correlated with clinical variables.
Results: Concordance between tests occurred in 81% of the overall values between FLI and NLFS, but was lower when comparing the other fibrosis scores (FIB-4 vs FORN 72%, FIB-4 vs BARD 36%, BARD vs FORN 46%, BARD vs BAAT 58%, FIB-4 vs BAAT 46%, BAAT vs FORN 62%). Each index was differently correlated with anthropometric, clinical and laboratory variables .
Conclusion: Indices evaluated retain low concordance, clinicians should be aware of these differences between steatosis/fibrosis scores when expressing a differential liver disease diagnosis or assessing the progression of a known liver disease.
Level of Evidence
Level V, descriptive research.