The purpose of this research is to synthesize environmentally friendly nanosorbents capable of Diesel Range Organics (DRO) adsorption from contaminated water. Central Composite Design (CCD) analysis of response surface methodology (RSM) was employed in a model fitting of the variables predicting the adsorption efficiency of Moringa Oleifera-functionalized zerovalent iron particles (ZINPs) for the removal of DRO. The effects of the reaction parameters on the response were screened using 24 factorial design to determine the statistically significant independent variables. A quadratic model predicting the DRO adsorption efficiency of ZINPs with an F-value of 276.84 (p-value <0.0001) was developed. Diagnostic plots show that the predicted values were in excellent agreement with actual experimental values (R2 = 0.99). The maximum percentage removal of DRO of 92.6% was achieved after optimization, using the synthesized ZINPs after 8 hours of contact between DRO substrates and ZINPs at pH of 8, the temperature of 25 ºC, with an adsorbent dosage of 2 g/L and at composite desirability of 1. Characterization of ZINPs revealed the formation of quasi nanospheres and nanocubes with an average particle diameter of 50.9 ± 9.7, the crystallite size of 15.31 nm, a crystallinity index of 32.47%, and pore width of 75.69 – 88.59 nm. The adsorption equilibrium data modelling of ZINPs for adsorption of DRO was best described by Langmuir isotherm with the maximum monolayer coverage capacity of 7.194 mg/g. The separation factor T, indicated favourable adsorption. The adsorption kinetic data were consistent with pseudo-second-order kinetics indicating probable chemisorption.