Background Hyperuricemia is often associated with oxidative stress and vitamin E alters uric acid level in hypertensive rats, consequently, vitamin E may have a significant role in non-hypertensive hyperuricemia. Therefore, we aimed to evaluate anti-hyperuricemic activity of vitamin E on potassium oxonate-induced hyperuricemic rats.
Methods Eighteen adult Wistar Albino rats of similar weights were equally divided into group I (normal control), group II (disease control) and group III (treatment control). Group I received 0.5ml normal saline per oral while group II and group III received potassium oxonate (250 mg/kg-intraperitoneal) on day 1, 3, 6, 10, 13 and 15. Group III also received vitamin E (200 mg/kg-per oral) for 15 days. Blood samples were collected through retro orbital plexus from all the animals on day 15 to evaluate uric acid, creatinine, total cholesterol, triglycerides, albumin and blood urea nitrogen, as well joint diameter, and kidneys’ weight was also evaluated.
Result We observed a statistically significant rise (p<0.05 or p<0.001) in all the parameters and a significant decline in serum albumin level (p<0.001) in group II as compared to group I, but no significant difference (p>0.05) in all the parameters between group I and III. In contrast to this, a significant reduction in all the parameters (p<0.05 or p<0.001) and significant increase in serum albumin level (p<0.001) were observed in group III as compared to group II.
Conclusion Our findings suggest that vitamin E has an anti-hyperuricemic activity against hyperuricemia induced rats.