To evaluate a new generation of commercial robotic (CR) the clinical practicability of stereotactic robotic system, operating accuracy and operation safety. We analyzed retrospectively in 08, 2018-2020 - June, during the application of CR type brain surgery robot system implementation frameless stereotactic brain surgery clinical data of 120 patients, observe clinical practicability, positioning accuracy and safety. Clin-ical successful completion of the frameless positioning brain surgery in 120 cases, the procedure goes well, no serious complications. Including registration and operation stage, the average operation time was 23.5 to 80.2 min. To the postoperative target accuracy evaluation, the results show that target error in 1.36 and 0.42 mm, 4 cases of patients with brain damaged kernel group, using three nail operation head frame fixed Mayfield, use solid coupling device to robot and heads fixed after surgery, results show that the target error in 0.92 and 0.21 mm, meet the operation requirements. The new generation of CR stereotactic robotic system has great improvement compared with the previous generation, which can apply to all types of stereotactic surgery at present, to enhance the practical operation, the structure design more reasonable, integrated practical operation, positioning precision and convenient operation, meet the demand of clinical application.