Visual outcomes of secondary lens implants in children with different etiologies

doi:10.21203/rs.3.rs-1356481/v1

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Research Article

Visual outcomes of secondary lens implants in children with different etiologies

https://doi.org/10.21203/rs.3.rs-1356481/v1

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posted 14 Feb, 2022

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Aim: This study investigated visual outcomes and factors that impact vision in children receiving secondary intraocular lens (IOL) implants.

Methods: Children who had traumatic or congenital cataracts and underwent secondary lens implantation for aphakia at Drashti Netralaya between 2000 and 2019 were retrospectively examined. We included all the eyes with secondary implants for aphakia correction with placement either in the bag or sulcus or through scleral fixation. We obtained data from electronic medical records and analyzed using SPSS 22 through descriptive analysis, cross tabulation, and t test.

We evaluated visual outcomes among different patients.

Results: Our cohort consisted of 84 eyes (mean age: 7.88 ± 6.07 years). Of the 84 eyes, 24 (28.6%) and 60 (71.4%) were female and male patients, respectively, and 32 (38.1%) had traumatic cataract. We observed significant improvements in vision following lens implantation (p=0.000). Those with nontraumatic cataracts exhibited better outcomes that did the traumatic cataract group (p = 0.004). Corneal opacity caused comorbidities in the traumatic group (14/52,14.29%). Visual outcomes significantly improved in young patients and were not affected by other variables.

Conclusion: Secondary lens implantation significantly improved vision in aphakic children. Young patients and those with nontraumatic cataracts demonstrated more favorable visual outcomes.

The estimated prevalence of congenital cataract (CC) ranges from 2.2 to 13.6 per 10,000 individuals globally [1]. Variations in prevalence among populations are likely attributable to the difference in factors among countries including screening programs, immunization rates, nutritional status, and population genetics [1,2]. Moreover, the necessity for treatment varies according to density of opacities at birth, partial cataracts at birth, and cataract progression during childhood. Optimal outcomes can be obtained through early identification and diagnosis and appropriate clinical care. Typically, a team of health-care professionals should manage children with cataracts. Moreover, well-established referral pipelines and clinical networks are crucial to achieve favorable outcomes. Although patient management, ranging from diagnosis to surgery, has substantially altered recently, variations are still noted among different countries.

Acquired monocular blindness is mainly caused by ocular trauma. Open-globe injury caused by intraocular foreign bodies, posttraumatic endophthalmitis, penetrating injuries, or ocular rupture results in poor vision outcomes (2–8). Posttraumatic endophthalmitis is a rare and severe complication of open-globe injury with a poor prognosis.

In infants, intraocular lens (IOL) implantation can be beneficial in terms of visual rehabilitation and reduce postoperative complications. However, the timing of implanting lens in children with congenital cataract must be carefully decided by considering age during surgery, postoperative complication risks, and treatment affordability of patients’ families along with the selection of suitable IOL power and type. IOL can be safely and effectively implanted in infants aged ≥ 6 who have well-developed eyeballs and satisfactory systemic conditions. Otherwise, surgeons can opt for secondary lens implants.

Congenital cataract, which is characterized by vision loss and amblyopia formation, is a treatable cause of loss of vision in childhood [1]. Visual rehabilitation can be successful when performed when children are aged < 3 months, which is considered the amblyogenic window [2]. The axial length rapidly increases until 2 to 3 years of age in healthy children [2]. Moreover, lens implantation after cataract removal can cause myopic shift in patients aged < 2 years. Furthermore, these children can develop cosniderable uveal inflammation [9,10] and intensive posterior capsule opacification. Because the safety and efficacy of IOL implantation remain controversial, primary cataract removal is preferred in cases detected early. Subsequently, contact lenses or spectacles can be employed for aphakia correction combined with amblyopia management [11,12]. In the Infant Aphakia Treatment Study, no differences in visual acuities were noted between children who had unilateral cataract and received primary lens implants and those using contact lenses for surgical aphakia correction [10]. Secondary lens implantation is opted when aphakic children aged > 2 years cannot tolerate wearing contact lenses or spectacles [13]. Limited studies have examined secondary IOL implantation’s long-term vision outcomes. This study investigated secondary IOL implantation’s long-term vision-related outcomes in children with aphakia aged > 2 years and potential factors impacting visual acuity postoperatively.

Secondary lens implantation result in satisfactory outcomes in vitrectomized eyes. After vitrectomy, spectacles can be employed for correcting vision. However, the technique and timing of secondary lens implantation to correct vitrectomized aphakia remain unclear, particularly for the loss of capsule integrity and zonular dialysis. Primary lens implantation performed during initial reconstruction resulted in satisfactory outcomes in injured eyes [8–11]. However, primary lens implantation can lead to complications including synechiae, fibrinous uveitis, retinal detachment, pupillary capture, and those related to the posterior segment (14–17).

We retrospectively evaluated the medical details of children receiving secondary lens implants between 2000 and 2019. The ethical committee approved this study. To ensure the identification of eligible children, a chronological surgery list was cross-referenced by performing a database search of children receiving treatment for traumatic or nontraumatic cataract. Children who were aged between 0 and 18 years during their secondary lens implantation, which was performed by a single surgeon, were examined. Children with congenital glaucoma or retinopathy of prematurity were excluded. In addition, those with incomplete data regarding cataract removal or postimplantation follow-up were excluded. Intra- and post-operative complications and visual outcomes at the final visit were evaluated.

Information regarding sex, age during surgery, ethnicity, cataract type, laterality, corneal diameter, keratometry, axial length determined through immersion A-scanning, age during IOL implantation, IOL power and type implanted, reason for IOL implantation, and site of IOL fixation was collected. All data were exported in the online pretest format and added in an Excel sheet; all data were examined using SPSS 22.

Descriptive analysis, cross tabulation, and t test were performed for statistical analyses. A P value of < 0.05 was considered to be statistically significant.

Aphakia is caused due to many factors in children. This study examined factors such as congenital cataract, open-globe ocular trauma, and congenital anomalies such as ectopia lentis unlike other studies that focused on congenital cataracts, traumatic cataracts, or ectopia lentis (3-8). Here, we compared visual outcomes for all categories. The nontraumatic category exhibited more favorable outcomes possibly due to comorbidities in traumatic cases (p=0.004; Table ).

Secondary lens were implanted in different locations, namely the bag and sulcus; scleral-fixated and posterior chamber iris claw lens were implanted. No significant differences were observed (p=0.09).

According to Wood et al., secondary lens implanted in the capsular bag resulted in fewer complications than did those in the ciliary sulcus. Many patients recruited to this study received implants in the capsular bag (69.4%). This finding may be responsible for low complication rates and indicates that capsular bag preservation is crucial for secondary lens implantation. However, this finding limits the generalizability of study results to other centers where a higher proportion received implants in the bag and sulcus (18).

The major complication or cause of nonimprovement of vision in this study was corneal opacity (12/84 patients, 14.29%, Table). A study reported VAO, secondary glaucoma, and refractive problem as causes in 5.4%, 16.4%, and 8.1% of patients, respectively. The current study included many (32/84) posttrauma cases causing corneal opacities (Table) (18).

The mean ages during secondary lens implantation were 94.56 ± 72.84, 55.2 ± 21.6, and 46.64 ± 29.37 months in our study, Wood et al.’s study, and Rong et al.’s study, respectively (18,19). This might be attributed to the lack of awareness in rural areas and ignorant parents. Owing to the low socioeconomic status, compliance of aphakic spectacles and contact lenses is poor, thus affecting the outcome because of amblyopia. The mean follow-up period was 3.53 ± 5.6 years in this study, 57.6 ± 33.6 months in Woods et al.’s study, and 109.09 ± 18.89 months in Rong et al.’s study, respectively. This difference can be due to variations in sociodemographic factors.

Furthermore, 42 (50%) and 12 (14.3%) of 84 (50%) patients achieved visual acuities of >6/24 and <1/60, respectively.

The median visual acuities reported by Woods et al. and Rong et al. at the final visit were 20/40 and 6/18, respectively. These results are similar to those reported by previous studies (16,17) including that conducted by Nihalani and Vanderveen (14) who demonstrated that 50% eyes had a BCVA of ≥20/40 and Shenoy et al. who found that 35% eyes had a BCVA of ≥20/40 (20).

Hu et al. demonstrated that secondary iris claw lens implantation resulted in satisfactory vision (21). Forlini indicated that retro pupillary iris claw lens is a suitable option for scleral-fixated or angle-supported lens (22). Retropupillary iris claw lens implantation can safely and effectively correct aphakia without capsule support (23,24).

He et al indicated that secondary lens implants can safely correct aphakia in for open-globe injury patients undergoing vitrectomy. This finding is in agreement with that of this study; we noted no differences in outcomes among various lens positions (25).

Secondary sulcus IOL could be implanted after preserving the anterior lens capsule during primary implantation in children with anterior PFV; this procedure resulted in favorable vision outcomes after operation and a compatible proportion of complications (26-28).

Yu and Maxwell observed favorable longer-term findings and few complications after sutured scleral-fixated foldable lens implantation. Their procedure is safe, does not need complex equipment, and can correct aphakia in the absence of adequate capsule support (29,30).

Edelstein S reported successful outcomes of scleral-fixated lens implants in congenital ectopia lentis, which is similar to this study (31).

This study compared the outcomes of various lens positions in different etiologies and exhibited no significant differences.

A strength of the present study is that the same surgeon operated all eyes. The study is limited by its retrospective nature; however, incomplete records were excluded. Future studies should include more patients and examine different postoperative complications. In addition, because young patients were enrolled, we could not perform BCVA Snellen measurements. A more standardized method for measuring visual acuity can be beneficial.

Secondary lens implantation significantly improved children’s vision. Outcomes were favorable for congenital than traumatic cataracts. Lens placement in the bag, sulcus, or through scleral fixation significantly affects the visual outcome.

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Table-1 Comparative study of visual out come amongst traumatic and non traumatic aetiology

Vision categories		Aetiology		Total
Vision categories		Nontraumatic	Traumatic	Total
	<1/60	4	8	12
	1/60-3/60	11	11	22
	6/60-6/36	3	5	8
	6/24-6/18	26	3	29
	6/12-6/9	7	4	11
	6/6-6/5	1	1	2
Total		52	32	84

P=0.004

Table-2 Comparative study of reasons for no improvement of vision amongst traumatic and non traumatic aetiology

Cause	Non Traumatic		Traumatic		Total
	No	%	No	%	No	%
Corneal opacity	4	7.69	10	31.25	14	14.29
Lens malposition	1	1.92	2	6.25	3	3.57
Inflammation	1	1.92	3	9.37	4	4.76
Ps problems	1	1.92	6	18.75	7	8.33
Secondary glaucoma	1	1.92	3	9.37	4	4.76
Amblyopia	4	7.69	0	0	4	4.76
Pseudophakic bullous keratopathy	1	1.92	2	6.25	3	3.57
Normal	36	69.23	9	28.12	45	53.57
Lost follow up	1	1.92	1	3.12	2	2.38
					84	100

Table-3 Comparative study of visual outcome according to Lens location

		IOL Placement				Total
		ACIOL	BAG	IN SULCUS	SFIOL	Total
	<1/60	0	0	8	4	12
	1/60-3/60	1	1	11	9	22
	6/60-6/36	0	1	4	3	8
	6/24-6/18	0	11	14	4	29
	6/12-6/9	0	0	7	4	11
	6/6-6/5	0	0	1	1	2
Total		1	13	45	25	84

P=0.09

Table-4 Comparative study of visual outcome according to Lens material

Vision Categories		IOLMATERIAL		Total
Vision Categories		Acrylic	PMMA	Total
	<1/60	0	12	12
	1/60-3/60	3	19	22
	6/60-6/36	0	8	8
	6/24-6/18	11	18	29
	6/12-6/9	0	11	11
	6/6-6/5	0	2	2
Total		14	70	84

No financial support was received from any company or institution.
This study has not been presented at any conference or meeting.
The authors have no financial interest in any aspect of this study.
Conflicting interests: None to declare.

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Visual outcomes of secondary lens implants in children with different etiologies

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