This preprint is under consideration at Molecular Autism. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research
Evan Suzman
Vanderbilt University
Corresponding Author
ORCiD: https://orcid.org/0000-0001-5265-336X
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Individuals on the autism spectrum are reported to display alterations in interoception, the sense of the internal state of the body. The Interoception Sensory Questionnaire (ISQ) is a 20-item self-report measure of interoception specifically intended to measure this construct in autistic people. Thus far, the ISQ has not undergone psychometric evaluation in a large sample.
Methods: Using confirmatory factor analysis, we evaluated the latent structure of the ISQ in a large online sample of adults on the autism spectrum and found that the unidimensional model fit the data poorly. Using misspecification analysis to identify areas of local misfit and item response theory to investigate the appropriateness of the 7-point response scale, we removed redundant items and collapsed the response options to put forth a novel 8-item, 5-response choice ISQ.
Results: The revised, 5-response choice ISQ (ISQ-8) showed much improved fit while maintaining high internal reliability. Differential item functioning (DIF) analyses indicated that the items ISQ-8 were answered in comparable ways by autistic adolescents and adults and across multiple other sociodemographic groups.
Limitations: Our results were limited by the fact that we did not collect data for typically developing controls, preventing the analysis of DIF by diagnostic status. Additionally, while this study proposes a new 5-response scale for the ISQ-8, our data were not collected using this method, and thus the psychometric properties for the revised version of this instrument require further investigation.
Conclusion: The ISQ-8 shows promise as a reliable and valid measure of interoception in adolescents and adults on the autism spectrum, but additional work is needed to examine its psychometrics in this population. A free online score calculator has been created to facilitate the use of ISQ-8 latent trait scores for further studies of autistic adolescents and adults (available at https://asdmeasures.shinyapps.io/ISQ_score/).
Keywords
autism, interoception, psychometric, reliability, validity, sensory, item response theory, measurement
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CURRENT STATUS: Under Review
Version 1
Posted 29 Dec, 2020
No community comments so far
Editorial decision: Major revision
On 10 Feb, 2021
Review #2 received
Received 08 Feb, 2021
Review #3 received
Received 05 Feb, 2021
Review #1 received
Received 18 Jan, 2021
Reviewer #3 agreed
On 17 Jan, 2021
Reviewer #2 agreed
On 06 Jan, 2021
Reviewer #1 agreed
On 03 Jan, 2021
Reviewers invited
Invitations sent on 28 Dec, 2020
Editor invited
On 25 Dec, 2020
Editor assigned
On 25 Dec, 2020
Submission checks complete
On 24 Dec, 2020
First submitted
On 21 Dec, 2020
Metrics
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PDF Downloads: ...
HTML Views: ...
Subject Areas
Cellular & Molecular Neuroscience
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This preprint is under consideration at Molecular Autism. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Evan Suzman
Vanderbilt University
Corresponding Author
ORCiD: https://orcid.org/0000-0001-5265-336X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 29 Dec, 2020
No community comments so far
Editorial decision: Major revision
On 10 Feb, 2021
Review #2 received
Received 08 Feb, 2021
Review #3 received
Received 05 Feb, 2021
Review #1 received
Received 18 Jan, 2021
Reviewer #3 agreed
On 17 Jan, 2021
Reviewer #2 agreed
On 06 Jan, 2021
Reviewer #1 agreed
On 03 Jan, 2021
Reviewers invited
Invitations sent on 28 Dec, 2020
Editor invited
On 25 Dec, 2020
Editor assigned
On 25 Dec, 2020
Submission checks complete
On 24 Dec, 2020
First submitted
On 21 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cellular & Molecular Neuroscience
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Individuals on the autism spectrum are reported to display alterations in interoception, the sense of the internal state of the body. The Interoception Sensory Questionnaire (ISQ) is a 20-item self-report measure of interoception specifically intended to measure this construct in autistic people. Thus far, the ISQ has not undergone psychometric evaluation in a large sample.
Methods: Using confirmatory factor analysis, we evaluated the latent structure of the ISQ in a large online sample of adults on the autism spectrum and found that the unidimensional model fit the data poorly. Using misspecification analysis to identify areas of local misfit and item response theory to investigate the appropriateness of the 7-point response scale, we removed redundant items and collapsed the response options to put forth a novel 8-item, 5-response choice ISQ.
Results: The revised, 5-response choice ISQ (ISQ-8) showed much improved fit while maintaining high internal reliability. Differential item functioning (DIF) analyses indicated that the items ISQ-8 were answered in comparable ways by autistic adolescents and adults and across multiple other sociodemographic groups.
Limitations: Our results were limited by the fact that we did not collect data for typically developing controls, preventing the analysis of DIF by diagnostic status. Additionally, while this study proposes a new 5-response scale for the ISQ-8, our data were not collected using this method, and thus the psychometric properties for the revised version of this instrument require further investigation.
Conclusion: The ISQ-8 shows promise as a reliable and valid measure of interoception in adolescents and adults on the autism spectrum, but additional work is needed to examine its psychometrics in this population. A free online score calculator has been created to facilitate the use of ISQ-8 latent trait scores for further studies of autistic adolescents and adults (available at https://asdmeasures.shinyapps.io/ISQ_score/).
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