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Research Article
Yahya Pasdar
Kermanshah University of Medical Sciences
Corresponding Author
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The aim of this study was the assess association between of dietary inflammatory index (DII) and non-invasive markers of liver status in adults. This cross-sectional study was performed on 8,520 adults, recruited in Ravansar Non-Communicable Diseases (RaNCD) cohort study, the west of Iran. DII score was calculated based on participants’ dietary intakes obtained from Food Frequency Questionnaire (FFQ). Fatty Liver Index (FLI) score was calculated by anthropometric measurements and some non-invasive markers of liver status. Linear regression models were used to estimate the associations and adjust for possible confounding factors. A greater DII score was significantly associated with higher energy intake, BMI (body mass index), BFM (body fat mass), blood pressure and FLI (P<0.001). Participants with the highest DII score had a significantly higher consumption saturated fat, trans fat and red meat than those in the lowest quartile (P<0.001). After adjustment for age and sex, participants in the highest quartile of DII score had a greater risk of FLI (β: 0.742, 95% CI: 0.254, 0.601). The more pro-inflammatory diet in participants was associated with higher FLI; DII score was positively associated with non-invasive liver markers. Thus having an anti-inflammatory diet can help balance liver enzymes, reduce obesity and fatty liver.
Keywords
Dietary inflammatory index, Fatty liver index, Non-alcoholic fatty liver disease
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On 27 Jan, 2021
Reviewer #3 agreed
On 27 Jan, 2021
Reviewer #25 agreed
On 27 Jan, 2021
Reviewer #1 agreed
On 27 Jan, 2021
Reviewer #4 agreed
On 27 Jan, 2021
Reviewer #24 agreed
On 27 Jan, 2021
Reviewer #32 agreed
On 27 Jan, 2021
Reviewer #17 agreed
On 27 Jan, 2021
Reviewer #9 agreed
On 27 Jan, 2021
Reviewer #2 agreed
On 27 Jan, 2021
Reviewer #16 agreed
On 27 Jan, 2021
Reviewer #8 agreed
On 27 Jan, 2021
Reviewer #10 agreed
On 27 Jan, 2021
Reviewer #33 agreed
On 27 Jan, 2021
Reviewer #30 agreed
On 27 Jan, 2021
Reviewer #18 agreed
On 27 Jan, 2021
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This preprint is under consideration at Scientific Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Yahya Pasdar
Kermanshah University of Medical Sciences
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 05 Jan, 2021
No community comments so far
Review #10 received
Received 12 Feb, 2021
Review #16 received
Received 12 Feb, 2021
Review #15 received
Received 12 Feb, 2021
Review #23 received
Received 12 Feb, 2021
Review #8 received
Received 12 Feb, 2021
Review #7 received
Received 12 Feb, 2021
Review #1 received
Received 12 Feb, 2021
Review #24 received
Received 12 Feb, 2021
Review #21 received
Received 12 Feb, 2021
Review #9 received
Received 12 Feb, 2021
Reviewer #7 agreed
On 27 Jan, 2021
Reviewer #19 agreed
On 27 Jan, 2021
Reviewer #3 agreed
On 27 Jan, 2021
Reviewer #25 agreed
On 27 Jan, 2021
Reviewer #1 agreed
On 27 Jan, 2021
Reviewer #4 agreed
On 27 Jan, 2021
Reviewer #24 agreed
On 27 Jan, 2021
Reviewer #32 agreed
On 27 Jan, 2021
Reviewer #17 agreed
On 27 Jan, 2021
Reviewer #9 agreed
On 27 Jan, 2021
Reviewer #2 agreed
On 27 Jan, 2021
Reviewer #16 agreed
On 27 Jan, 2021
Reviewer #8 agreed
On 27 Jan, 2021
Reviewer #10 agreed
On 27 Jan, 2021
Reviewer #33 agreed
On 27 Jan, 2021
Reviewer #30 agreed
On 27 Jan, 2021
Reviewer #18 agreed
On 27 Jan, 2021
Reviewers invited
Invitations sent on 26 Jan, 2021
Editor assigned
On 14 Jan, 2021
Editor invited
On 04 Jan, 2021
Submission checks complete
On 31 Dec, 2020
First submitted
On 25 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The aim of this study was the assess association between of dietary inflammatory index (DII) and non-invasive markers of liver status in adults. This cross-sectional study was performed on 8,520 adults, recruited in Ravansar Non-Communicable Diseases (RaNCD) cohort study, the west of Iran. DII score was calculated based on participants’ dietary intakes obtained from Food Frequency Questionnaire (FFQ). Fatty Liver Index (FLI) score was calculated by anthropometric measurements and some non-invasive markers of liver status. Linear regression models were used to estimate the associations and adjust for possible confounding factors. A greater DII score was significantly associated with higher energy intake, BMI (body mass index), BFM (body fat mass), blood pressure and FLI (P<0.001). Participants with the highest DII score had a significantly higher consumption saturated fat, trans fat and red meat than those in the lowest quartile (P<0.001). After adjustment for age and sex, participants in the highest quartile of DII score had a greater risk of FLI (β: 0.742, 95% CI: 0.254, 0.601). The more pro-inflammatory diet in participants was associated with higher FLI; DII score was positively associated with non-invasive liver markers. Thus having an anti-inflammatory diet can help balance liver enzymes, reduce obesity and fatty liver.
Figure 1
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