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Research article
Hafiz Abdul Basit Siddiqui
Aga Khan University Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4202-548X
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Fatty infiltration of the liver represents the intracytoplasmatic accumulation of triglycerides in the hepatocytes. We determined if H. pylori infection contributes to fatty liver infiltration and if it was related to gastric mucosal changes. As fatty liver disease is seen prevalent in non obese non alcohol consuming population of some asian countries. Methods: This cross-sectional study conducted between 22/11/2016 to 30/06/2018 in the Department of Medicine Aga Khan University Hospital. Eligible patients were enrolled after taking informed consent. Sociodemographic data were collected on age, gender, smoking and alcohol use, along with medical history related to dyslipidemia, hypertension, Type 2 diabetes mellitus, and ischemic heart disease. Fatty liver infiltrations were assessed using ultrasonography. H.pylori infection was detected by using carbon urea breath test (14C-UBT). Results: A total of 698 patients were enrolled during the study period with a mean age of 44.01±16.03 years and male patients were 373 (53%). A total of x patients were present with dyspepsia of the 299 (57%) of the patients were found to have positive H. pylori test. Of 299 patients with positive H. pylori test, 153 (20%) of the patients were diagnosed as having fatty liver infiltrations. H. pylori infection induced chronic active gastritis was associated with fatty liver infiltration in 62(71%) and absent in 200(64%) (P= 0.264). Conclusion: The frequency of fatty liver infiltration in Helicobacter Pylori infected dyspeptic patients was 20%. Age and BMI are associated with fatty liver among dyspeptic H. pylori patients. Keywords: H. pylori, Fatty liver, BMI > 23; Type 2 diabetes. This is due to the incorporation of proinflammatory cytokines by the helicobacter pylori and its impact on gut microbiota leading to leaky gut and GUT-LIVER-AXIS interaction at different levels. Despite low BMI in our population, fatty liver is seen in connection with helicobacter pylori related gastric mucosal inflammation.
Keywords
H. pylori, Fatty liver, BMI > 23; Type 2 diabetes.
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Hafiz Abdul Basit Siddiqui
Aga Khan University Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4202-548X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 17 Jun, 2019
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Gastroenterology & Hepatology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Fatty infiltration of the liver represents the intracytoplasmatic accumulation of triglycerides in the hepatocytes. We determined if H. pylori infection contributes to fatty liver infiltration and if it was related to gastric mucosal changes. As fatty liver disease is seen prevalent in non obese non alcohol consuming population of some asian countries. Methods: This cross-sectional study conducted between 22/11/2016 to 30/06/2018 in the Department of Medicine Aga Khan University Hospital. Eligible patients were enrolled after taking informed consent. Sociodemographic data were collected on age, gender, smoking and alcohol use, along with medical history related to dyslipidemia, hypertension, Type 2 diabetes mellitus, and ischemic heart disease. Fatty liver infiltrations were assessed using ultrasonography. H.pylori infection was detected by using carbon urea breath test (14C-UBT). Results: A total of 698 patients were enrolled during the study period with a mean age of 44.01±16.03 years and male patients were 373 (53%). A total of x patients were present with dyspepsia of the 299 (57%) of the patients were found to have positive H. pylori test. Of 299 patients with positive H. pylori test, 153 (20%) of the patients were diagnosed as having fatty liver infiltrations. H. pylori infection induced chronic active gastritis was associated with fatty liver infiltration in 62(71%) and absent in 200(64%) (P= 0.264). Conclusion: The frequency of fatty liver infiltration in Helicobacter Pylori infected dyspeptic patients was 20%. Age and BMI are associated with fatty liver among dyspeptic H. pylori patients. Keywords: H. pylori, Fatty liver, BMI > 23; Type 2 diabetes. This is due to the incorporation of proinflammatory cytokines by the helicobacter pylori and its impact on gut microbiota leading to leaky gut and GUT-LIVER-AXIS interaction at different levels. Despite low BMI in our population, fatty liver is seen in connection with helicobacter pylori related gastric mucosal inflammation.
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