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Research
Lan Zhang
Provincial Hospital Affiliated to Anhui Medical University
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: Pulmonary surfactant(PS) replacement therapy is well known as a necessary method to preterm respiratory distress syndrome(RDS). INSURE technique bring up injury of trachea and high incidence rate of bronchopulmonary dysplasia(BPD), while less invasive surfactant administration(LISA) caught increasingly attention.
Objective: Compare the outcomes and side effect between LISA group and INSURE group.
Methods: We collected 20 cases from eight neonatal intensive care units (NICU) in Anhui Province in China for LISA group and 36 cases from the first Hospital Affiliated of USTC for INSURE group, and the outcomes and side effect were analyzed.
Results: Re-intubation rate(20% vs 22.2%) and the incidence of BPD(40% vs 47.2%) in LISA group were lower than those in INSURE group, but there were no statistical differences. The mortality in two group show no diffrence.
Conclusion: LISA technique can decrease the re-intubation rate and BPD incidence without increasing mortality.
Keywords
LISA, BPD, INSURE, preterm, RDS
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Lan Zhang
Provincial Hospital Affiliated to Anhui Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 04 Jan, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pediatrics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Pulmonary surfactant(PS) replacement therapy is well known as a necessary method to preterm respiratory distress syndrome(RDS). INSURE technique bring up injury of trachea and high incidence rate of bronchopulmonary dysplasia(BPD), while less invasive surfactant administration(LISA) caught increasingly attention.
Objective: Compare the outcomes and side effect between LISA group and INSURE group.
Methods: We collected 20 cases from eight neonatal intensive care units (NICU) in Anhui Province in China for LISA group and 36 cases from the first Hospital Affiliated of USTC for INSURE group, and the outcomes and side effect were analyzed.
Results: Re-intubation rate(20% vs 22.2%) and the incidence of BPD(40% vs 47.2%) in LISA group were lower than those in INSURE group, but there were no statistical differences. The mortality in two group show no diffrence.
Conclusion: LISA technique can decrease the re-intubation rate and BPD incidence without increasing mortality.
The full text of this article is available to read as a PDF.
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