This preprint is under consideration at Italian Journal of Pediatrics. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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LISA VS. INSURE_Which One is Appropriate? -A Cohort Study of PS Administration Technology in Preterm RDS in Multicenter of Anhui Province
Lan Zhang
Provincial Hospital Affiliated to Anhui Medical University
Corresponding Author
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Background: Pulmonary surfactant(PS) replacement therapy is well known as a necessary method to preterm respiratory distress syndrome(RDS). INSURE technique bring up injury of trachea and high incidence rate of bronchopulmonary dysplasia(BPD), while less invasive surfactant administration(LISA) caught increasingly attention.
Objective: Compare the outcomes and side effect between LISA group and INSURE group.
Methods: We collected 20 cases from eight neonatal intensive care units (NICU) in Anhui Province in China for LISA group and 36 cases from the first Hospital Affiliated of USTC for INSURE group, and the outcomes and side effect were analyzed.
Results: Re-intubation rate(20% vs 22.2%) and the incidence of BPD(40% vs 47.2%) in LISA group were lower than those in INSURE group, but there were no statistical differences. The mortality in two group show no diffrence.
Conclusion: LISA technique can decrease the re-intubation rate and BPD incidence without increasing mortality.
Keywords
LISA, BPD, INSURE, preterm, RDS
Due to technical limitations, full-text HTML conversion of this manuscript could not be completed. However, the manuscript can be downloaded and accessed as a PDF.
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CURRENT STATUS: Under Review
Version 1
Posted 04 Jan, 2021
No community comments so far
Reviewers invited
Invitations sent on 11 Jan, 2021
Editor assigned
On 25 Dec, 2020
Submission checks complete
On 25 Dec, 2020
Editor invited
On 25 Dec, 2020
First submitted
On 17 Dec, 2020
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This preprint is under consideration at Italian Journal of Pediatrics. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
LISA VS. INSURE_Which One is Appropriate? -A Cohort Study of PS Administration Technology in Preterm RDS in Multicenter of Anhui Province
Lan Zhang
Provincial Hospital Affiliated to Anhui Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 04 Jan, 2021
No community comments so far
Reviewers invited
Invitations sent on 11 Jan, 2021
Editor assigned
On 25 Dec, 2020
Submission checks complete
On 25 Dec, 2020
Editor invited
On 25 Dec, 2020
First submitted
On 17 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pediatrics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Pulmonary surfactant(PS) replacement therapy is well known as a necessary method to preterm respiratory distress syndrome(RDS). INSURE technique bring up injury of trachea and high incidence rate of bronchopulmonary dysplasia(BPD), while less invasive surfactant administration(LISA) caught increasingly attention.
Objective: Compare the outcomes and side effect between LISA group and INSURE group.
Methods: We collected 20 cases from eight neonatal intensive care units (NICU) in Anhui Province in China for LISA group and 36 cases from the first Hospital Affiliated of USTC for INSURE group, and the outcomes and side effect were analyzed.
Results: Re-intubation rate(20% vs 22.2%) and the incidence of BPD(40% vs 47.2%) in LISA group were lower than those in INSURE group, but there were no statistical differences. The mortality in two group show no diffrence.
Conclusion: LISA technique can decrease the re-intubation rate and BPD incidence without increasing mortality.
Due to technical limitations, full-text HTML conversion of this manuscript could not be completed. However, the manuscript can be downloaded and accessed as a PDF.