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Original investigation
Jehad Abubaker
Dasman Diabetes Institute
Corresponding Author
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Background: IGFBP4 is the smallest member of the insulin-like growth factor binding protein family (IGFBP). It’s a hepatic protein that plays a role in modulating the activity and bioavailability of IGF-I. The expression of IGFBP4 was found to increase under conditions of hypoxia. Obstructive Sleep Apnea (OSA) is a common disorder, characterized by cyclic episodes of intermittent hypoxia and fragmented sleep.
Methods: We quantified levels of circulating IGFBP1, IGFBP2, IGFBP3, IGFBP4 and IGFBP7 in fasting plasma samples of 67 Kuwaiti participant using Multiplexing assay. The study involved 28 controls, and 39 patients with OSA.
Results: Levels of circulating IGFBP4 were significantly higher in people with OSA (253.65 ±20.46 ng/ml) compared to the control group (173.35 ±20.86 ng/ml, p = 0.008). There was an increase in levels of IGFBP3 and IGFBP7, however it was not significant. People with OSA had a significantly high AHI score (22.99 ±3.39 events/h) in comparison to the control (2.12 ±0.2 events/h). The increase in IGFBP4 correlated positively to IGFBP7 (r = 0.422, P = 0.01). There was a significant decline in circulating IGFBP4 after 3-months of surgery (225.89 ±18.16 ng/ml, p = 0.012). This was accompanied by a prominent improvement in OSA (AHI 8.97 ± 2.37 events/h, p = 0.001).
Conclusion: In this study our data showed a significant increase in circulating IGFBP4 in people with OSA. we also report a significant positive correlation between IGFBP4 and IGFBP7 at baseline, which suggests a potential synergy in the actions of IGFBP4 and IGFBP7 at conditions of OSA-induced hypoxia. OSA significantly improved after 3-month of surgical intervention, which concurred with a significant decline in IGFBP4 levels. Altogether, this suggests a potential role for IGFBP4 in OSA-induced hypoxia.
Keywords
IGFBP4, IGFBP7, Hypoxia, AHI, OSA
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Original investigation
Jehad Abubaker
Dasman Diabetes Institute
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 30 Dec, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cardiac & Cardiovascular Systems
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: IGFBP4 is the smallest member of the insulin-like growth factor binding protein family (IGFBP). It’s a hepatic protein that plays a role in modulating the activity and bioavailability of IGF-I. The expression of IGFBP4 was found to increase under conditions of hypoxia. Obstructive Sleep Apnea (OSA) is a common disorder, characterized by cyclic episodes of intermittent hypoxia and fragmented sleep.
Methods: We quantified levels of circulating IGFBP1, IGFBP2, IGFBP3, IGFBP4 and IGFBP7 in fasting plasma samples of 67 Kuwaiti participant using Multiplexing assay. The study involved 28 controls, and 39 patients with OSA.
Results: Levels of circulating IGFBP4 were significantly higher in people with OSA (253.65 ±20.46 ng/ml) compared to the control group (173.35 ±20.86 ng/ml, p = 0.008). There was an increase in levels of IGFBP3 and IGFBP7, however it was not significant. People with OSA had a significantly high AHI score (22.99 ±3.39 events/h) in comparison to the control (2.12 ±0.2 events/h). The increase in IGFBP4 correlated positively to IGFBP7 (r = 0.422, P = 0.01). There was a significant decline in circulating IGFBP4 after 3-months of surgery (225.89 ±18.16 ng/ml, p = 0.012). This was accompanied by a prominent improvement in OSA (AHI 8.97 ± 2.37 events/h, p = 0.001).
Conclusion: In this study our data showed a significant increase in circulating IGFBP4 in people with OSA. we also report a significant positive correlation between IGFBP4 and IGFBP7 at baseline, which suggests a potential synergy in the actions of IGFBP4 and IGFBP7 at conditions of OSA-induced hypoxia. OSA significantly improved after 3-month of surgical intervention, which concurred with a significant decline in IGFBP4 levels. Altogether, this suggests a potential role for IGFBP4 in OSA-induced hypoxia.
Figure 1
Figure 2
Figure 3
Figure 4
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